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Noriomi Kuribayashi Hiroyuki Hata Hiromitsu Matsuzaki Minoru Yoshida Takashi Sonoki Akitoshi Nagasaki Tatsuya Kimura Naoko Harada Kiyoshi Takatsuki 《Cancer immunology, immunotherapy : CII》1998,15(4):248-254
Resistance of myeloma cells to melphalan (L-PAM) is a serious problem. To investigate mechanisms of drug resistance, we generated
a monoclonal antibody, clone O3, to melphalan-resistant myeloma cells, KHM-11R. Western blot analysis showed that molecular
weight of O3 antigen was approximately 90 kDa. Expression of O3 antigen was approximately two times higher in KHM-11R than
in parental melphalan sensitive cell line, KHM-11. O3 was preferentially expressed in plasma cell, B-cell, and monocytic cell
lines, but not in T-cell lines. Analysis of bone marrow samples from myeloma patients revealed that 13 of 23 samples expressed
O3 antigen at various levels, and that O3 antigen expression in patients correlate with preceding chemotherapy, advanced clinical
stage and extramedullar invasion of myeloma cells. Furthermore, patients expressing O3 antigen at the time of diagnosis tended
to have poor prognosis. The investigation of O3 antigen in myeloma cells will be useful to reveal the pathophysiology of extramedullar
invasion and the mechanism of cell killing by melphalan. 相似文献
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Kikuchi Suzuka Sakamoto Takuya Matsunaga Sachihiro Iwamoto Akitoshi 《Journal of plant research》2023,136(3):423-428
Journal of Plant Research - Whole-mount fluorescent in situ hybridization (WM-FISH) is an effective tool to observe chromosome behavior in tissues or organs. However, it is difficult to obtain a... 相似文献
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