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191.
Rajasekaran Ekambaram Akila Kannaiyan Vijayasarathy Marimuthu Vinobha Chinnaiah Swaminathan Senthil Renganathan Ananda Gopu Perumal 《Bioinformation》2014,10(3):138-143
Spatial arrangement of carbon in protein structure is analyzed here. Particularly, the carbon fractions around individual atoms are
compared. It is hoped that it follows the principle of 31.45% carbon around individual atoms. The results reveal that globular
protein''s atoms follow this principle. A comparative study on monomer versus dimer reveal that carbon is better distributed in
dimeric form than in its monomeric form. Similar study on solid versus liquid structures reveals that the liquid (NMR) structure
has better carbon distribution over the corresponding solid (X-Ray) structure. The carbon fraction distributions in fiber and toxin
protein are compared. Fiber proteins follow the principle of carbon fraction distribution. At the same time it has another broad
spectrum of carbon distribution than in globular proteins. The toxin protein follows an abnormal carbon fraction distribution. The
carbon fraction distribution plays an important role in deciding the structure and shape of proteins. It is hoped to help in
understanding the protein folding and function. 相似文献
192.
Widespread use of antifungal drugs in prophylactic and therapeutic settings is associated with breakthrough infections primarily
due to Aspergillus and non-Aspergillus molds and non-albicans Candida. Reasons for breakthrough include worsening of initial infection, superinfection, and co-infection; subtherapeutic drug levels,
emergence of antifungal resistance, and host factors may contribute to progression of the initial infection. Establishing
an etiologic diagnosis is crucial because clinical and radiological features are nonspecific, and empirically chosen drug(s)
may not provide appropriate antimicrobial coverage. Evidence-based data do not exist for the management of breakthrough infection.
Current treatment strategies include switching therapy to a drug of another class, dose optimization, and combinations of
drugs. Dosage adjustment of triazoles guided by serum concentrations may ensure optimal efficacy and avoidance of toxicity.
A combination of an echinocandin plus a triazole or polyene appears to be synergistically effective against invasive aspergillosis.
The treatment strategy needs to be individualized. For an optimal outcome, reversal of immunosuppression is essential. 相似文献
193.
194.
This paper is concerned with the problem of stability and pinning synchronization of a class of inertial memristive neural networks with time delay. In contrast to general inertial neural networks, inertial memristive neural networks is applied to exhibit the synchronization and stability behaviors due to the physical properties of memristors and the differential inclusion theory. By choosing an appropriate variable transmission, the original system can be transformed into first order differential equations. Then, several sufficient conditions for the stability of inertial memristive neural networks by using matrix measure and Halanay inequality are derived. These obtained criteria are capable of reducing computational burden in the theoretical part. In addition, the evaluation is done on pinning synchronization for an array of linearly coupled inertial memristive neural networks, to derive the condition using matrix measure strategy. Finally, the two numerical simulations are presented to show the effectiveness of acquired theoretical results. 相似文献
195.
C. Santharam K. N. Ponnusamy B. Chandrasekar 《Biometrical journal. Biometrische Zeitschrift》1996,38(6):725-730
Block designs for observations correlated in one dimension are investigated. Santharam and Ponnusamy (1995) investigated the universal optimality of Nearest Neighbour balanced block designs (NNBD) using first order correlated models (AR(1), MA(1) and ARMA(1,1)). In this article we have investigated the universal optimality of NNBD using second order correlated models (ar(2), and MA (2)). 相似文献
196.
Warwick RM Armitage WJ Chandrasekar A Mallinson G Poniatowski S Clarkson A 《Cell and tissue banking》2012,13(1):53-61
Transplanted tissues have transmitted transmissible spongiform encephalopathies and in the UK there have been more cases of
variant Creutzfeldt-Jakob disease (vCJD) than elsewhere in the world. A pilot study was undertaken to look at the feasibility
of testing for vCJD in deceased donors using tonsillar tissue. This pilot showed that obtaining consent for removal and testing
tonsil tissue was feasible. Donor eligibility for inclusion in the pilot was limited to tissue donors from the National Health
Service Blood and Transplant, Tissue Services and to donors shared with the Corneal Transplant Service Eye Banks. Obtaining
tonsillar tissue in the immediate post–mortem period was limited by the presence of rigor mortis. Tonsillar tissue was suitable
for routine analysis for the presence of prion associated with vCJD in deceased tissue donors. Production and processing of
tissue was straightforward and a low assay background was obtained from most samples. Since palatine and lingual tonsil tissue
can be obtained in pairs it was possible, in the majority of cases, to set aside an intact sample for confirmatory testing
if required. In one instance a sample was reactive by Western blot. However, the pattern of reactivity was not typical for
that obtained from vCJD patients. Unfortunately the sample was not of sufficient quality for the confirmatory test to provide
a conclusive result. 相似文献
197.
Imen Khammari Fatma Saghrouni Alia Yaacoub Sondoss Gaied Meksi Hinda Ach Lamia Garma Akila Fathallah Moncef Ben Sa?d 《The Korean journal of parasitology》2013,51(4):485-488
The performance values of available techniques used in serodiagnosis of toxoplasmosis are satisfactory but they raise problems of equivocal and discordant results for very low IgG titers. Recently marketed, LDBio-Toxo II IgG Western blot (IB) showed an excellent correlation with the dye test. We estimated the proportion of equivocal and discordant results between the enzyme immunoassay Platelia Toxo IgG (EIA-IgG) and fluorescent antibody test (FAT) and assessed the usefulness of the IB as a confirmatory test. Out of 2,136 sera collected from pregnant women, 1,644 (77.0%) tested unequivocally positive and 407 (19.0%) were negative in both EIA-IgG and FAT. The remaining 85 (4%) sera showed equivocal or discordant results. Among them, 73 (85.9%) were positive and 12 (14.1%) were negative in IB. Forty-one (89.1%) equivocal sera in EIA-IgG and 46 (86.8%) equivocal sera in FAT were positive in IB. Reducing the cut-off values of both screening techniques improved significantly their sensitivity in detecting very low IgG titers at the expense of their specificity. In conclusion, equivocal results in routine-used techniques and their discordance in determination of the immune status in pregnancy women were not uncommon. IB test appeard to be highly useful in these situations as a confirmatory technique. 相似文献
198.
The role of hydrophobic force in biological function through the formation of several local macro-molecular structures is evident.
Carbon is the element that contributes to biological function in living systems. We show that carbon distribution is related to
protein activity using an example. The carbon distribution profile is foreseen to help undestand unfolded and misfolded regions of
protein structures. The carbon distribution profile in a toxin protein that is found associated with the toxic shock syndrome is
described in this study. The carbon profile provides insight to the association of specific residues responsible for toxicity. 相似文献
199.
Jayaraman Selvaraj Rajagopal Ponnulakshmi Veeraraghavan Vishnupriya Chandrasekar Kirubhanand 《Bioinformation》2020,16(10):731
Staphylococcal enterotoxins (SEs) are liked with food poisoning and other related infections. Nafcillin is an antibiotic used to treat S. aureus. Therefore, it is of interest to study the molecular interactions of 25 nafcillin analogues with enterotoxin I using molecular docking analysis. The analysis shows optimal interaction features of Nafcillin analogues with Enterotoxin I from Staphylococcus aureus for further consideration. 相似文献
200.
Veroniek S. M. Saegeman Akila Chandrasekar Marja J. van Wijk Hilde Beele Monica M. Montenero Aurora Navarro Caroline Van Geyt Arlinke G. Bokhorst Deirdre Fehily Ruth M. Warwick 《Cell and tissue banking》2009,10(4):351-357
The European Association of Tissue Banks (EATB) Donor Case Workshop is a forum held within the programme of the EATB annual Congress since 2003. This workshop has been used to discuss clinical donor cases with peer review of practice. It was agreed in advance that the experience of the 2007 workshop should be shared by publication as an example of participative learning which can be extended to other fields within tissue banking and which may be applicable in other disciplines. The EATB Congress in 2008 will extend the idea of participative open workshops with two additional workshops, one on Quality System cases and another on heart valve cases. 相似文献