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441.
Kanjun Hirunagi Kentaro Kiyoshi Akihito Adachi Minoru Hasegawa Shizufumi Ebihara Horst-W. Korf 《Cell and tissue research》1994,278(2):415-418
Vasoactive intestinal peptide (VIP)-like immunoreactive terminal fields were examined in the lateral septum of the pigeon by means of immunocytochemistry. According to light-microscopic observations, these projections originated from VIP-like immunoreactive cerebrospinal fluid (CSF)-contacting neurons, which are located in the ependymal layer of the lateral septum and form a part of the lateral septal organ. The processes of these cells gave rise to dense terminal-like structures in the lateral septum. Pre-embedding immuno-electron microscopy revealed that VIP-like immunoreactive axon terminals had synaptoid contacts with perikarya of small VIP-immunonegative neurons of the lateral septum, which were characterized by an invaginated nucleus, numerous mitochondria, a well-developed Golgi apparatus, endoplasmic reticulum and a small number of dense-core vesicles (about 100 nm in diameter). VIP-like immunoreactive axons were also seen in contact with immunonegative dendrites in the lateral septum. In both axosomatic and axodendritic connections, VIP-like immunoreactive presynaptic terminals contained large dense-core vesicles, clusters of small vesicles and mitochondria. These findings suggest that VIP-immunoreactive neurons of the lateral septal organ project to small, presumably peptidergic nerve cells of the lateral septum and that the VIP-like neuropeptide serves as a neuromodulator (-transmitter) in this area. 相似文献
442.
Akihito Shimazu Wilmar B Schaufeli Daisuke Miyanaka Noboru Iwata 《BioPsychoSocial medicine》2010,4(1):17
With the globalization of occupational health psychology, more and more researchers are interested in applying employee well-being
like work engagement (i.e., a positive, fulfilling, work-related state of mind that is characterized by vigor, dedication,
and absorption) to diverse populations. Accurate measurement contributes to our further understanding and to the generalizability
of the concept of work engagement across different cultures. The present study investigated the measurement accuracy of the
Japanese and the original Dutch versions of the Utrecht Work Engagement Scale (9-item version, UWES-9) and the comparability
of this scale between both countries. Item Response Theory (IRT) was applied to the data from Japan (N = 2,339) and the Netherlands
(N = 13,406). Reliability of the scale was evaluated at various levels of the latent trait (i.e., work engagement) based the
test information function (TIF) and the standard error of measurement (SEM). The Japanese version had difficulty in differentiating
respondents with extremely low work engagement, whereas the original Dutch version had difficulty in differentiating respondents
with high work engagement. The measurement accuracy of both versions was not similar. Suppression of positive affect among
Japanese people and self-enhancement (the general sensitivity to positive self-relevant information) among Dutch people may
have caused decreased measurement accuracy. Hence, we should be cautious when interpreting low engagement scores among Japanese
as well as high engagement scores among western employees. 相似文献
443.
Fukumoto Satoshi; Yamamoto Akihito; Hasegawa Tomokazu; Abe Kuniko; Takamiya Kogo; Okada Masahiko; Min Zhao Jin; Furukawa Keiko; Miyazaki Hiroshi; Tsuji Yoshiro; Goto George; Suzuki Misao; Shiku Hiroshi; Furukawa Koichi 《Glycobiology》1997,7(8):1111-1120
Several lines of transgenic mice with gangliosides GM2/GD2 synthasegene were established, and the expression levels of the transgenein brain, liver, spleen and thymus were analyzed by comparingwith those in their litter mates. Among four tissues, brainand skin showed markedly high expression levels of the transgenein Northern blotting. Particularly, transgenic mice skin showedabout 10-fold higher expression of GM2/GD2 synthase gene thanthe wild type mice skin. Therefore, alterations in the morphology,glycolipid components, and responses to the exogenous stimulationsin the transgenic mice skin were examined. Gangliosides in thetransgenic skin were dramatically converted from GM3 to GM1,whereas no morphological changes were observed. However, whenskin flap test was performed with insertion of nylon membranesunder the skin flaps, much stronger inflammatory reactions consistingof edema, marked thickness, and cell infiltration were observedin the transgenic mice compared with the wild type. Similarenhanced inflammatory reaction was also observed in the skininjected by silicon gel, and in the peritoneal reaction to theinjected casein. Main cell population in these inflammatoryreactions consisted of neutrophils, suggesting an increasedsensitivity of neutrophils to chemo-tactic factors in the transgenicmice. ganglioside glycosyltransferase GM2 GD2 synthase skin transgenic mouse 相似文献
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Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide. Immobilized human TM exhibited both anticoagulant activity and inhibition of platelet aggregation of human blood. 相似文献