Kamyar Kalantar‐Zadeh  Seyed‐Foad Ahmadi 《Obesity (Silver Spring, Md.)》2016,24(2):281-282

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Marise R. Heerma van Voss  Kai Kammers  Farhad Vesuna  Justin Brilliant  Yehudit Bergman  Saritha Tantravedi  Xinyan Wu  Robert N. Cole  Andrew Holland  Paul J. van Diest  Venu Raman 《Translational oncology》2018,11(3):755-763

DDX3 is an RNA helicase with oncogenic properties. The small molecule inhibitor RK-33 is designed to fit into the ATP binding cleft of DDX3 and hereby block its activity. RK-33 has shown potent activity in preclinical cancer models. However, the mechanism behind the antineoplastic activity of RK-33 remains largely unknown. In this study we used a dual phosphoproteomic and single cell tracking approach to evaluate the effect of RK-33 on cancer cells. MDA-MB-435 cells were treated for 24?hours with RK-33 or vehicle control. Changes in phosphopeptide abundance were analyzed with quantitative mass spectrometry using isobaric mass tags (Tandem Mass Tags). At the proteome level we mainly observed changes in mitochondrial translation, cell division pathways and proteins related to cell cycle progression. Analysis of the phosphoproteome indicated decreased CDK1 activity after RK-33 treatment. To further evaluate the effect of DDX3 inhibition on cell cycle progression over time, we performed timelapse microscopy of Fluorescent Ubiquitin Cell Cycle Indicators labeled cells after RK-33 or siDDX3 exposure. Single cell tracking indicated that DDX3 inhibition resulted in a global delay in cell cycle progression in interphase and mitosis. In addition, we observed an increase in endoreduplication. Overall, we conclude that DDX3 inhibition affects cells in all phases and causes a global cell cycle progression delay.  相似文献   

    

Hadi Fahimi  Mehdi Chalani  Zeinab Asadi  Siamak Broomand  Nahid Ahmadi 《Zoology in the Middle East.》2018,64(2):182-184

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Hamed Mohammadi  Maryam Hemmatzadeh  Farhad Babaie  Arezoo Gowhari Shabgah  Gholamreza Azizi  Fatemeh Hosseini  Jafar Majidi  Behzad Baradaran 《Journal of cellular physiology》2018,233(8):5564-5573

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Hamed Mohammadi  Nadia Sharafkandi  Maryam Hemmatzadeh  Gholamreza Azizi  Mohammad Karimi  Farhad Jadidi‐Niaragh  Behzad Baradaran  Zohreh Babaloo 《Journal of cellular physiology》2018,233(6):4512-4529

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Ali Moradi  Faezeh Ghasemi  Kazem Anvari  Seyed Mahdi Hassanian  Saeideh Ahmadi Simab  Safieh Ebrahimi  Amirreza Hesari  Mohammad Mahdi Forghanifard  Mohammad Taher Boroushaki  Soodabeh ShahidSales  Amir Avan 《Journal of cellular physiology》2017,232(12):3221-3225

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Gelavizh Barzegar  Reza Darvishi Cheshmeh Soltani  Mehdi Ahmadi  Reza Saeedi  Mehrnoosh Abtahi 《Soil & Sediment Contamination》2017,26(5):538-557

In the current study, Fe₃O₄ NPs were synthesized and used as catalysts in a sono-Fenton-like process for remediation of polycyclic aromatic hydrocarbon (PAH)-contaminated soil. The effects of operational variables were studied using central composite design (CCD) optimization approach. Results indicated that the effects of H₂O₂ concentration, Fe₃O₄ NPs dosage, ultrasonic power and pH were significant for pyrene removal as a contaminant model. In optimum experimental conditions, including H₂O₂ concentration of 78 mM, Fe₃O₄ NPs dosage of 18 mM, ultrasonic power of 313 W and pH value of 3.46, the observed pyrene removal was obtained 98.37%, which was verified through the additional experimental tests (99.33%). Pseudo first-order kinetic model was well fitted with the experimental data of pyrene removal with significant coefficient of correlation (R²: 0.9672). Accordingly, an unwashed real soil sample containing diffident PAHs (pyrene, flurene, acenaphthylene, phenenthrene, chrysene, etc) was subjected to sono-Fenton-like process based on optimized conditions. The obtained findings revealed that the removal (%) ranged between 37.7% and 85.19% for different PAHs.  相似文献   

    

Meshginqalam  Bahar  Ahmadi  Mohammad Taghi  Sabatyan  Arash  Ismail  Razali 《Plasmonics (Norwell, Mass.)》2017,12(4):1193-1198

Extraordinary electrical and optical features of graphene-based materials attract researchers to improve sensing center of different sensors using them. In this research, the effects of sensing molecules on electro-optical features of graphene-based sensors are modeled. The adsorption effect on the Hamiltonian of the system based on tight-binding model is explored, and also the system band structure is investigated analytically. Then, refractive index deviations based on band gap variations are discovered which are used in response modeling of a graphene-based surface plasmon resonance (SPR) sensor.

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Mahshid Ahmadi  Yu‐Che Hsiao  Ting Wu  Qing Liu  Wei Qin  Bin Hu 《Liver Transplantation》2017,7(4)

Judicious choice of transport layer in organic–inorganic halide perovskite solar cells can be one of the essential parameters in photovoltaic design and fabrication techniques. This article reports the effect of optically generated dipoles in transport layer on the photovoltaic actions in active layer in perovskite solar cells with the architecture of indium tin oxide (ITO)/TiO _x /CH₃NH₃PbI_3–x Cl _x /hole transport layer (HTL)/Au. Here, PTB7‐thieno[3,4‐b]thiophene‐alt‐benzodithiophene and P3HT‐poly(3‐hexylthiophene) are separately used as the HTL with significant and negligible photoinduced dipoles, respectively. Electric field‐induced photoluminescence quenching provides the first‐hand evidence to indicate that the photoinduced dipoles are partially aligned in the amorphous PTB7 layer under the influence of device built‐in field. By monitoring the recombination process through magneto‐photocurrent measurements under device operation condition, it is shown that the photoinduced dipoles in PTB7 layer can decrease the recombination of photogenerated carriers in the active layer in perovskite solar cells. Furthermore, the capacitance measurements suggest that the photoinduced dipoles in PTB7 can decrease charge accumulation at the electrode interface. Therefore, the studies indicate the important role of photoinduced dipoles in the HTL on charge recombination dynamics and provide a fundamental insight on how the polarization in transport layer can influence the device performance in perovskite solar cells.  相似文献   

    

Sorour Nemati  Aysa Rezabakhsh  Ali Baradar Khoshfetrat  Alireza Nourazarian  Çığır Biray Avci  Bakiye Goker Bagca  Hamed Alizadeh Sardroud  Majid Khaksar  Mahdi Ahmadi  Aref Delkhosh  Emel Sokullu  Reza Rahbarghazi 《Biotechnology and bioengineering》2017,114(12):2920-2930

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