全文获取类型
收费全文 | 5310篇 |
免费 | 254篇 |
国内免费 | 181篇 |
专业分类
5745篇 |
出版年
2024年 | 17篇 |
2023年 | 64篇 |
2022年 | 158篇 |
2021年 | 316篇 |
2020年 | 142篇 |
2019年 | 187篇 |
2018年 | 210篇 |
2017年 | 165篇 |
2016年 | 229篇 |
2015年 | 273篇 |
2014年 | 306篇 |
2013年 | 429篇 |
2012年 | 393篇 |
2011年 | 410篇 |
2010年 | 233篇 |
2009年 | 197篇 |
2008年 | 226篇 |
2007年 | 205篇 |
2006年 | 203篇 |
2005年 | 165篇 |
2004年 | 127篇 |
2003年 | 103篇 |
2002年 | 106篇 |
2001年 | 65篇 |
2000年 | 65篇 |
1999年 | 51篇 |
1998年 | 31篇 |
1997年 | 15篇 |
1996年 | 23篇 |
1995年 | 17篇 |
1993年 | 18篇 |
1992年 | 31篇 |
1991年 | 47篇 |
1990年 | 41篇 |
1989年 | 33篇 |
1988年 | 29篇 |
1987年 | 43篇 |
1986年 | 30篇 |
1985年 | 36篇 |
1984年 | 28篇 |
1983年 | 20篇 |
1982年 | 17篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 24篇 |
1978年 | 24篇 |
1977年 | 13篇 |
1975年 | 14篇 |
1974年 | 13篇 |
1973年 | 20篇 |
排序方式: 共有5745条查询结果,搜索用时 15 毫秒
71.
72.
Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents
Saleem Ahmad Khehyong Ngu Keith J. Miller Ginger Wu Chen-pin Hung Sarah Malmstrom Ge Zhang Eva O’Tanyi William J. Keim Mary Jane Cullen Kenneth W. Rohrbach Michael Thomas Thao Ung Qinling Qu Jinping Gan Rangaraj Narayanan Mary Ann Pelleymounter Jeffrey A. Robl 《Bioorganic & medicinal chemistry letters》2010,20(3):1128-1133
Agonists of the 5-HT2C receptor have been shown to suppress appetite and reduce body weight in animal models as well as in humans. However, agonism of the related 5-HT2B receptor has been associated with valvular heart disease. Synthesis and biological evaluation of a series of novel and highly selective dihydroquinazolinone-derived 5-HT2C agonists with no detectable agonism of the 5-HT2B receptor is described. Among these, compounds (+)-2a and (+)-3c were identified as potent and highly selective agonists which exhibited weight loss in a rat model upon oral dosing. 相似文献
73.
Imran Ahmad Jay Prakash Thakur Debabrata Chanda Dharmendra Saikia Feroz Khan Shivani Dixit Amit Kumar Rituraj Konwar Arvind Singh Negi Atul Gupta 《Bioorganic & medicinal chemistry letters》2013,23(5):1322-1325
Lipophilic chalcones and their conformationally restricted analogues were synthesized and evaluated for their antitubercular efficacy against Mycobacterium tuberculosis H37Rv strain. Compounds 16, 24, 25a and 25c were found to be active MIC at 60, 30, 3.5 and 7.5 μg-mL?1. In vitro cytotoxicity of compounds 16, 24, 25a, 25c and 26 in non-cancerous human epithelial kidney cell line (HEK-293) showed that most active compound 25a was approximately 2.85 times selective towards tubercular versus healthy cells whereas compound 24 was found to be 16 times selective. 相似文献
74.
Kamran Ashraf Altaf Ahmad Anis Chaudhary Mohd. Mujeeb Sayeed Ahmad Mohd. Amir N. Mallick 《Saudi Journal of Biological Sciences》2014,21(2):159-165
The present investigation was undertaken for the assessment of 12 accessions of Zingiber officinale Rosc. collected from subcontinent of India by RAPD markers. DNA was isolated using CTAB method. Thirteen out of twenty primers screened were informative and produced 275 amplification products, among which 261 products (94.90%) were found to be polymorphic. The percentage polymorphism of all 12 accessions ranged from 88.23% to 100%. Most of the RAPD markers studied showed different levels of genetic polymorphism. The data of 275 RAPD bands were used to generate Jaccard’s similarity coefficients and to construct a dendrogram by means of UPGMA. Results showed that ginger undergoes genetic variation due to a wide range of ecological conditions. This investigation was an understanding of genetic variation within the accessions. It will also provide an important input into determining resourceful management strategies and help to breeders for ginger improvement program. 相似文献
75.
76.
Md Sultan Ahamad Sahabjada Siddiqui Asif Jafri Sheeba Ahmad Mohammad Afzal Md Arshad 《PloS one》2014,9(10)
A natural predominant flavanone naringenin, especially abundant in citrus fruits, has a wide range of pharmacological activities. The search for antiproliferative agents that reduce skin carcinoma is a task of great importance. The objective of this study was to analyze the anti-proliferative and apoptotic mechanism of naringenin using MTT assay, DNA fragmentation, nuclear condensation, change in mitochondrial membrane potential, cell cycle kinetics and caspase-3 as biomarkers and to investigate the ability to induce reactive oxygen species (ROS) initiating apoptotic cascade in human epidermoid carcinoma A431 cells. Results showed that naringenin exposure significantly reduced the cell viability of A431 cells (p<0.01) with a concomitant increase in nuclear condensation and DNA fragmentation in a dose dependent manner. The intracellular ROS generation assay showed statistically significant (p<0.001) dose-related increment in ROS production for naringenin. It also caused naringenin-mediated epidermoid carcinoma apoptosis by inducing mitochondrial depolarization. Cell cycle study showed that naringenin induced cell cycle arrest in G0/G1 phase of cell cycle and caspase-3 analysis revealed a dose dependent increment in caspase-3 activity which led to cell apoptosis. This study confirms the efficacy of naringenin that lead to cell death in epidermoid carcinoma cells via inducing ROS generation, mitochondrial depolarization, nuclear condensation, DNA fragmentation, cell cycle arrest in G0/G1 phase and caspase-3 activation. 相似文献
77.
Superoxide anion (O
2
.–
) was photogenerated upon illumination of riboflavin in fluorescent light. The rate of O
2
.–
formation was stimulated by double stranded DNA but not by denatured DNA or RNA. Depurinated DNA, which was predominantly depleted in guanine residues, did not exhibit the stimulatory effect, indicating an interaction of riboflavin, or active oxygen species derived from it, with guanine bases. Also, the stimulation of O
2
.–
photogeneration was not observed with ethidium bromide but was seen with proflavin-intercalated DNA. Since ethidium bromide intercalates preferentially between purines and pyrimidines, and proflavin prefers dA-dT rich sites, these results were interpreted to suggest that the interaction of riboflavin with DNA is mainly with GC or CG base pairs. 相似文献
78.
79.
80.