全文获取类型
收费全文 | 468篇 |
免费 | 39篇 |
专业分类
507篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 2篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 8篇 |
2016年 | 14篇 |
2015年 | 28篇 |
2014年 | 26篇 |
2013年 | 26篇 |
2012年 | 33篇 |
2011年 | 26篇 |
2010年 | 23篇 |
2009年 | 26篇 |
2008年 | 21篇 |
2007年 | 33篇 |
2006年 | 25篇 |
2005年 | 22篇 |
2004年 | 16篇 |
2003年 | 23篇 |
2002年 | 11篇 |
2001年 | 13篇 |
2000年 | 15篇 |
1999年 | 4篇 |
1998年 | 7篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1967年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有507条查询结果,搜索用时 15 毫秒
501.
Intrinsic Mechanics and Control of Fast Cranio-Cervical Movements in Aquatic Feeding Turtles 总被引:2,自引:0,他引:2
Aerts Peter; van Damme Johan; Herrel Anthony 《Integrative and comparative biology》2001,41(6):1299-1310
Aquatic feeding strikes on agile prey in snake-necked turtlesinvolve fast neck extension, bucco-pharyngo-oesophageal expansion,and head retraction. The ultimate, rectilinear accelerationof the head towards the prey requires complex vertebral rotations,that vary widely from strike to strike. This poses complex motorcontrol issues for the numerous intrinsic neck-muscles, whichare the sole neck extensors. Mathematical modelling revealsthat extensor activity might be superfluous for this phase ofthe strike. The ultimate acceleration of the head at the endof the strike always coincides with forceful oropharyngeal expansion.The momentum of the induced flow of water is sufficient to pullthe head (and the neck) straight towards the prey. This buccalexpansion proceeds identically to that observed in primary aquaticfeeders: a rostro-caudal expansion sequence characterized byan optimal timing of the functional components supporting theexpansion wave. Yet distinct structural solutions, both at theskeletal, and muscular level, are involved. This points towardsprominent hydrodynamic constraints. Head and neck are retractedby extrinsic neck muscles. Given the high number of degreesof freedom, this musculo-skeletal system is obviously under-determined,which compromises control. We propose that erroneous foldingof the neck (i.e., diverging from the highly persistent retractedconfiguration) might be avoided through the presence of a subtleclick system at the level of the joint between cervical vertebrae5 and 6. 相似文献
502.
D A Van Sluijters G M Van Woerkom J M Aerts A J Meijer 《European journal of biochemistry》1999,266(2):653-659
Breakdown of plasma-membrane sphingomyelin caused by TNF-alpha is known to inhibit glucose metabolism and insulin signalling in muscle and fat cells. In hepatocytes, conversion of glucose to glycogen is strongly activated by amino acid-induced cell swelling. In order to find out whether breakdown of plasma-membrane sphingomyelin also inhibits this insulin-independent process, the effect of addition of sphingomyelinase was studied in rat hepatocytes. Sphingomyelinase (but not ceramide) inhibited glycogen synthesis, caused cell shrinkage, decreased the activity of glycogen synthase a, but had no effect on phosphorylase a. Cell integrity was not affected by sphingomyelinase addition as gluconeogenesis and the intracellular concentration of ATP were unchanged. As a control, glycogen synthesis was studied in HepG2 cells. In these cells, the basal rate of glycogen production was high, could not be stimulated by amino acids, nor be inhibited by sphingomyelinase. Regarding the mechanism responsible for the inhibition of glycogen synthase a, sphingomyelinase did not affect amino acid-induced, PtdIns 3-kinase-dependent, phosphorylation of p70S6 kinase, but caused an increase in intracellular chloride, which is known to inhibit glycogen synthase phosphatase. It is concluded that the decrease in cell volume, following the breakdown of sphingomyelin in the plasma membrane of the hepatocyte, may contribute to the abnormal metabolism of glucose when TNF-alpha levels are high. 相似文献
503.
The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans 总被引:1,自引:0,他引:1
An M. Aerts Sophie Lefevre Isabelle E.J.A. François Renata Santos Karin Thevissen 《FEBS letters》2009,583(15):2513-2516
We show that the antifungal plant defensin Raphanus sativus antifungal protein 2 (RsAFP2) from radish induces apoptosis and concomitantly triggers activation of caspases or caspase-like proteases in the human pathogen Candida albicans. Furthermore, we demonstrate that deletion of C. albicans metacaspase 1, encoding the only reported (putative) caspase in C. albicans, significantly affects caspase activation by the apoptotic stimulus acetic acid, but not by RsAFP2. To our knowledge, this is the first report on the induction of apoptosis with concomitant caspase activation by a defensin in this pathogen. Moreover, our data point to the existence of at least two different types of caspases or caspase-like proteases in C. albicans. 相似文献
504.
505.
R J Aerts 《Cell differentiation》1988,23(1-2):125-131
The cytoplasmic pH (pHi) of populations of developing Dictyostelium discoideum cells was determined by means of two independent pH null-point methods. Both methods reveal in populations containing 75-80% prespore cells a pHi value of about 0.2 pH units higher than in populations containing 50% prespore cells. During the process of cell type regulation, decreases and increases in the percentage of prespore cells of about 15-20% are accompanied by decreases and increases in pHi of about 0.2 pH units. Abolition of these changes in pHi by means of a weak base or acid also prevents the regulation process. It is concluded that changes in pHi are involved in the prespore cell type regulation in D. discoideum. 相似文献
506.
Antarctic terrestrial ecosystems are nutrient-poor and depend for their functioning in part on external nutrients. However,
little is known about the relative importance of various sources. We measured external mineral nutrient sources (wind blown
material, precipitation and guano) at three locations, the cold temperate oceanic Falkland Islands (51°76′S), and the Maritime
Antarctic Signy (60°71′S) and Anchorage Islands (67°61′S). These islands differ in the level of vegetation development through
different environmental constraints and historical factors. Total mineral nitrogen input differed considerably between the
islands. During the 3 month summer period it amounted to 18 mg N m−2 on the Falkland Islands and 6 and 102 mg N m−2 at Signy and Anchorage Islands, respectively. The high value for Anchorage was a result of guano deposition. By measuring
stable isotopic composition (δ15N) of the different nitrogen sources and the dominant plant species, we investigated the relative utilisation of each source
by the vegetation at each island. We conclude that external mineral nitrogen inputs to Antarctic terrestrial ecosystems show
great spatial variability, with the local presence of bird (or other vertebrate) colonies being particularly significant. 相似文献
507.