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61.
62.
Ganguly B Banerjee J Elegbede AI Klocke DJ Mallik S Srivastava DK 《FEBS letters》2007,581(29):5723-5726
We provide evidence that matrix metalloproteinase-7 (MMP-7) interacts with anionic, cationic and neutral lipid membranes, although it interacts strongest with anionic membranes. While the catalytic activity of the enzyme remains unaffected upon binding to neutral and negatively charged membranes, it is drastically impaired upon binding to the positively charged membranes. The structural data reveal that the origin of these features lies in the "bipolar" distribution of the electrostatic surface potentials on the crystallographic structure of MMP-7. 相似文献
63.
Ezra Olatunde Ogundare Adebukola Bidemi Ajite Adewuyi Temidayo Adeniyi Adefunke Olarinre Babatola Adekunle Bamidele Taiwo Odunayo Adebukola Fatunla Alfred Airemionkhale Oluwapelumi Adeyosola Odeyemi Oladele Simeon Olatunya Oyeku Akibu Oyelami 《PLoS neglected tropical diseases》2021,15(12)
BackgroundNeonatal Tetanus (NNT) is a vaccine preventable disease of public health importance. It is still being encountered in clinical practice largely in developing countries including Nigeria.NNT results from unhygienic delivery practices and some harmful traditional cord care practices.The easiest, quickest and most cost-effective preventive measure against NNT is vaccination of the pregnant women with the tetanus toxoid (TT) vaccine. The case-fatality rate from tetanus in resource-constrained settings can be close to 100% but can be reduced to 50% if access to basic medical care with adequate number of experienced staff is available.Materials and methodsThis retrospective study reviewed the admissions into the Special Care Baby Unit (SCBU) of the Ekiti State University Teaching Hospital, Ado-Ekiti from January 2011 to December 2020. The folders were retrieved from the records department of the hospital; Information obtained from folders were entered into a designed proforma for the study.ResultsDuring the study period, NNT constituted 0.34% of all neonatal admissions with case fatality rate of 52.6%. Seven [36.8%] of the babies were delivered at Mission home/Traditional Birth Attendant’s place while 5 [26.3%] were delivered in private hospitals. Cord care was with hot water compress in most of these babies16 [48.5%] while only 9% of the mothers cleaned the cord with methylated spirit. Age at presentation of less than one week was significantly associated with mortality, same with presence of autonomic dysfunction. Low family socio-economic class 5 was significantly associated with poor outcome, so also maternal age above 24 years.ConclusionThis study revealed that neonatal tetanus is still being seen in our clinical practice with poor outcome and the risk factors are the same as of old.Increased public health campaign, promotion of clean deliveries, safe cord care practices, affordable and accessible health care provision are recommended to combat NNT scourge. 相似文献
64.
Aflatoxin B1, crude aflatoxins and palmotoxins B0 and G0 were tested for seed germination and chlorophyll formation using the cowpea. It was found that aflatoxin B and crude aflatoxins inhibited both chlorophyll formation and seed germination and palmotoxins inhibited these processes to a lesser extent. 3 — Indolylacetic acid reduced the inhibitory effects of the aflatoxins in seed germination and chlorophyll formation in the cowpea. 相似文献
65.
66.
Enis Boletini Martina Svobodova Vladimir Divoky Erol Baysal Mehmet A. Cürük Aleksandar J. Dimovski Rong Liang Adekunle D. Adekile Titus H. J. Huisman 《Human genetics》1994,93(2):182-187
We have analyzed the hemoglobin abnormalities in nearly 50 Albanian patients with a significant hemoglobinopathy and included 37 relatives in this study. Sickle cell anemia (SS) is a common disorder; all 15 sickle cell anemia patients had the complications expected for this disease. The s haplotype was type 19 (Benin); -thalassemia-2 was rare. Three -thalassemia alleles (IVS-I-110, GA; codon 39, CT; IVS-I-6, TC) were present in nearly 85% of the -thalassemia alleles; their frequencies were intermediate between those observed in the populations of neighboring countries. A few rare mutations were also found, which might have originated in India, Turkey, Macedonia, and Greece. Nearly all patients with Hb S--thalassemia had the IVS-I-110 (GA) mutation. The frequencies of 11 -thalassemia mutations in 17 mostly Mediterranean countries have been reviewed. 相似文献
67.
Nnaemeka C. Iriemenam Adekunle O. Sanyaolu Wellington A. Oyibo Adetayo F. Fagbenro-Beyioku 《Parasitology international》2010,59(1):9-14
The immune system is a highly evolved network of cells and molecules that can distinguish between invading pathogens and the body's own cells. But helminths, in their complex forms, are capable of down-regulating host immunity, protecting them from being eliminated and also minimizing severe pathology in the host. This review focuses on Strongyloides stercoralis and the immune responses in immunocompetent and/or immunocompromised individuals. It also highlights the implications for diagnosis/treatment and draws attention to an emerging public health disease. The solution to reducing the prevalence of strongyloidiasis remains on the effectiveness of pre-emptive measures in endemic communities, increased awareness, prompt early diagnosis as well as timely treatment. 相似文献
68.
Sarkar N Banerjee J Hanson AJ Elegbede AI Rosendahl T Krueger AB Banerjee AL Tobwala S Wang R Lu X Mallik S Srivastava DK 《Bioconjugate chemistry》2008,19(1):57-64
We offer a novel methodology for formulating liposomes by incorporating sequence-specific collagen-mimetic peptides such that they are specifically "uncorked" by a matrix metalloproteinase, MMP-9. By encapsulating carboxyfluorescein (as a self-quenching fluorescent dye), we demonstrate that the time-dependent release of the dye from liposomes is due to the specific enzymatic cleavage of the surface-exposed collagen-mimetic peptides. The specificity of such cleavage is attested by the fact that the liposomal "uncorking" and their content release occur only by MMP-9 and not by a general proteolytic enzyme, trypsin, despite the fact that the collagen mimetic peptides contain the trypsin cleavage site. The mechanistic details underlying the formulations of liposomes and their enzyme-selective "uncorking" and content release are discussed. Arguments are presented that such liposomes can be fine-tuned to serve as the drug delivery vehicles for the detection and treatment of various human diseases, which occur due to the overexpression of a variety of pathogenic matrix metalloproteinases. 相似文献
69.
Sunday Adekunle Adebusoye Flynn W. Picardal Matthew O. Ilori Olukayode O. Amund 《World journal of microbiology & biotechnology》2008,24(7):1203-1208
The biodegradation of polychlorinated biphenyls (PCBs) by diverse bacteria including those utilized in this study is often
incomplete, a concomitant accumulation of chlorobenzoic acids (CBAs) are released as dead-end products. The build-up of these
metabolites in the growth medium may result in feed-back inhibition and impede PCB biotransformation. In this investigation
using GC-ECD and HPLC analyses, we confirmed that CBAs inhibit growth and PCB biodegradation potentials of five tropical bacteria
namely, Pseudomonas aeruginosa SA-1, Enterobacter sp. SA-2, Ralstonia sp. SA-3, Ralstonia sp. SA-5 and Pseudomonas sp. SA-6. Among the four CBAs (2-CBA, 3-CBA, 4-CBA acids and 2,3-diCBA), 3-CBA was the strongest inhibitor followed by 4-CBA.
Furthermore, we found that 3-CBA heavily inhibited growth of SA-3 and SA-6 on monochlorobiphenyls by 82–90% while elimination
rate was inhibited by 71–88%. In the case of 2,3-diCBA, inhibition was generally less than 60%. However, effects of both acids
were stronger in SA-3 than SA-6. We also found that 3-CBA and 2,3-diCBA completely inhibited carbon-chloride cleavage of 2-CB
and 3-CB since cultivation in the absence of the acids resulted in recovery of 23–50% chloride in the culture fluids of organisms.
These findings may therefore, have practical and ecological significance and are useful for improving the efficiency and the
stability of some biological treatment processes. 相似文献
70.
Phospholipid (PL) molecules form the main structure of the membrane that prevents the direct contact of opposing articular cartilage layers. In this paper we conceptualise articular cartilage as a giant reverse micelle (GRM) in which the highly hydrated three-dimensional network of phospholipids is electrically charged and able to resist compressive forces during joint movement, and hence loading. Using this hypothetical base, we describe a hydrophilic-hydrophilic (HL-HL) biopair model of joint lubrication by contacting cartilages, whose mechanism is reliant on lamellar cushioning. To demonstrate the viability of our concept, the electrokinetic properties of the membranous layer on the articular surface were determined by measuring via microelectrophoresis, the adsorption of ions H, OH, Na and Cl on phospholipid membrane of liposomes, leading to the calculation of the effective surface charge density. The surface charge density was found to be -0.08+/-0.002cm(-2) (mean+/-S.D.) for phospholipid membranes, in 0.155M NaCl solution and physiological pH. This value was approximately five times less than that measured in 0.01M NaCl. The addition of synovial fluid (SF) to the 0.155M NaCl solution reduced the surface charge density by 30% which was attributed to the binding of synovial fluid macromolecules to the phospholipid membrane. Our experiments show that particles charge and interact strongly with the polar core of RM. We demonstrate that particles can have strong electrostatic interactions when ions and macromolecules are solubilized by reverse micelle (RM). Since ions are solubilized by reverse micelle, the surface entropy influences the change in the charge density of the phospholipid membrane on cartilage surfaces. Reverse micelles stabilize ions maintaining equilibrium, their surface charges contribute to the stability of particles, while providing additional screening for electrostatic processes. 相似文献