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151.
Oh RS Pan WC Yalcin A Zhang H Guilarte TR Hotamisligil GS Christiani DC Lu Q 《The Journal of biological chemistry》2012,287(8):6025-6034
152.
Dembitzer FR Kinoshita Y Burstein D Phelps RG Beasley MB Garcia R Harpaz N Jaffer S Thung SN Unger PD Ghebrehiwet B Peerschke EI 《The journal of histochemistry and cytochemistry》2012,60(6):467-474
The gC1qR (i.e., gC1q receptor, gC1q binding protein, p32, p33) is a multifunctional cellular protein that interacts with components of the complement, kinin, and coagulation cascades and select microbial pathogens. Enhanced gC1qR expression has been reported in adenocarcinomas arising in a variety of organs. The present study compared gC1qR expression in normal, inflammatory, dysplastic, and malignant tissue of epithelial and mesenchymal origin. gC1qR expression was visualized in tissue sections by immunohistochemistry using the 60.11 monoclonal antibody (i.e., IgG(1) mouse monoclonal antibody directed against gC1qR) and the UltraVision LP Detection System. Sections were counterstained with hematoxylin and examined by light microscopy. Strongest gC1qR expression was noted in epithelial tumors of breast, prostate, liver, lung, and colon, as well as in squamous and basal cell carcinoma of the skin. However, increased gC1qR staining was appreciated also in inflammatory and proliferative lesions of the same cell types, as well as in normal continuously dividing cells. In contrast, tumors of mesenchymal origin generally stained weakly, with the exception of osteoblasts, which stained in both benign and malignant tissues. The data suggest that increased gC1qR expression may be a marker of benign and pathologic cell proliferation, particularly in cells of epithelial origin, with potential diagnostic and therapeutic applications. 相似文献
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155.
Md. Abdullahil Baque Abdullah Elgirban Eun-Jung Lee Kee-Yoeup Paek 《Acta Physiologiae Plantarum》2012,34(2):405-415
The effect of initial sucrose concentration was investigated in root suspension cultures of Morinda citrifolia to improve root growth and secondary metabolites production, i.e. anthraquinone, phenolics and flavonoids. Besides, oxidative
stress level, antioxidant enzymes activity and membranes damage under different sucrose concentration were estimated. A 5%
sucrose supply was shown to be optimal for the production of root dry mass, but higher sucrose concentrations of 7–9% inhibited
the accumulation of root dry weight (DW). However, the maximum production of anthraquinone (251.89 g L−1 DW), phenolics (165.14 g L−1 DW) and flavonoids (163.56 g L−1 DW) were achieved at 1% sucrose-treated culture, which may be a source carbon skeletons for secondary metabolism. At the
same time was observed low oxidative damage, which could be associated with high levels of secondary metabolites and the increased
activity of catalase. Although, catalase (CAT) activity were stimulated at 7–9% sucrose-treated cultures, high accumulation
of hydrogen peroxide (H2O2) and peroxidation of lipid (MDA) was induced. The observed high activity of CAT and guaiacol peroxidase (G-POD) were not
sufficient enough to mitigate the toxic effect of H2O2. 相似文献
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157.
The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10-17) with Br, OMe, CO, and OH were also obtained. Inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II, IV, and VI, with compounds 2-4, 8, and 10-26 was investigated. These compounds were found to be promising carbonic anhydrase inhibitors and some of them showed interesting inhibitory activity. Some of the compounds investigated here showed effective hCA inhibitory activity, and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, and osteoporosis. 相似文献
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Balaydın HT Soyut H Ekinci D Göksu S Beydemir S Menzek A Sahin E 《Journal of enzyme inhibition and medicinal chemistry》2012,27(1):43-50
(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl)methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new bromophenols. Inhibition of human cytosolic carbonic anhydrase II (hCA II) isozyme by these new bromophenols and naturally occurring 3,4,6-tribromo-5-(2,5-dibromo-3,4-dihydroxybenzyl)benzene-1,2-diol (3), and 5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-diol) (4) was investigated. The synthesized compounds showed carbonic anhydrase inhibitory capacities with IC(50) values in the range of 0.7-372 μM against hCA II. Some bromophenols investigated here showed effective hCA II inhibitory activity and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, or osteoporosis. 相似文献
160.
Aruna Govindaraju Alper Uzun LaShonda Robertson Mehmet O Atli Abdullah Kaya Einko Topper Elizabeth A Crate James Padbury Andy Perkins Erdogan Memili 《Reproductive biology and endocrinology : RB&E》2012,10(1):1-10