ICI 182,780 (ICI) belongs to a new class of antiestrogens developed to be pure estrogen antagonists and, in addition to its
therapeutic use, it has been used to knock-out estrogen and estrogen receptor (ER) actions in several mammalian species. In
the present study, the effects and mechanism of action of ICI were investigated in the teleost fish, sea bream (Sparus auratus). 相似文献