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Background
Pelodera (Rhabditis) strongyloides is a small saprophytic nematode that lives in decaying organic matter. On rare occasions, it can invade the mammalian skin, causing a pruritic, erythematous, alopecic and crusting dermatitis on skin sites that come into contact with the ground. Diagnosis of the disease is based on case history (a dog living outdoors on damp straw bedding) with characteristic skin lesions and on the demonstration of typical larvae in skin scrapings or biopsy. Pelodera (rhabditic) dermatitis cases have been reported mainly from Central European countries and the United States. 相似文献325.
We develop and investigate a continuum model for invasion of a domain by cells that migrate, proliferate and differentiate.
The model is applicable to neural crest cell invasion in the developing enteric nervous system, but is presented in general
terms and is of broader applicability. Two cell populations are identified and modeled explicitly; a population of precursor
cells that migrate and proliferate, and a population of differentiated cells derived from the precursors which have impaired
migration and proliferation. The equation describing the precursor cells is based on Fisher’s equation with the addition of
a carrying-capacity limited differentiation term. Two variations of the proliferation term are considered and compared. For
most parameter values, the model admits a traveling wave solution for each population, both traveling at the same speed. The
traveling wave solutions are investigated using perturbation analysis, phase plane methods, and numerical techniques. Analytical
and numerical results suggest the existence of two wavespeed selection regimes. Regions of the parameter space are characterized
according to existence, shape, and speed of traveling wave solutions. Our observations may be used in conjunction with experimental
results to identify key parameters determining the invasion speed for a particular biological system. Furthermore, our results
may assist experimentalists in identifying the resource that is limiting proliferation of precursor cells. 相似文献
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Parisha P. Shah Wenjian Lv Joshua H. Rhoades Andrey Poleshko Deepti Abbey Matthew A. Caporizzo Ricardo Linares-Saldana Julie G. Heffler Nazish Sayed Dilip Thomas Qiaohong Wang Liam J. Stanton Kenneth Bedi Michael P. Morley Thomas P. Cappola Anjali T. Owens Kenneth B. Margulies David B. Frank Rajan Jain 《Cell Stem Cell》2021,28(5):938-954.e9
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Bases and spaces: resources on the web for accessing the draft human genome - II - After publication of the draft 下载免费PDF全文
Colin AM Semple 《Genome biology》2001,2(6):reviews2001.1-reviews20016
The volume of human genome sequence and the variety of web-based tools to access it continue to grow at an impressive rate, but a working knowledge of certain key resources can be sufficient to get the most from your genome. This article provides an update to Genome Biology 2000, 1(4):reviews2001.1-2001.5. 相似文献