全文获取类型
收费全文 | 1567篇 |
免费 | 88篇 |
国内免费 | 6篇 |
专业分类
1661篇 |
出版年
2024年 | 2篇 |
2023年 | 22篇 |
2022年 | 52篇 |
2021年 | 63篇 |
2020年 | 60篇 |
2019年 | 86篇 |
2018年 | 70篇 |
2017年 | 54篇 |
2016年 | 70篇 |
2015年 | 88篇 |
2014年 | 103篇 |
2013年 | 137篇 |
2012年 | 108篇 |
2011年 | 118篇 |
2010年 | 68篇 |
2009年 | 62篇 |
2008年 | 53篇 |
2007年 | 55篇 |
2006年 | 43篇 |
2005年 | 37篇 |
2004年 | 39篇 |
2003年 | 25篇 |
2002年 | 22篇 |
2001年 | 3篇 |
2000年 | 11篇 |
1999年 | 12篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 5篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 18篇 |
1989年 | 15篇 |
1988年 | 22篇 |
1987年 | 16篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 14篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1975年 | 4篇 |
1957年 | 1篇 |
1956年 | 2篇 |
排序方式: 共有1661条查询结果,搜索用时 0 毫秒
41.
Frial Abbas Denis Picot Joël Merlet Bruno Cargnelutti Bruno Lourtet Jean-Marc Angibault Tanguy Daufresne Stéphane Aulagnier Hélène Verheyden 《European Journal of Wildlife Research》2013,59(1):69-75
In open landscapes, grass leaves provide an abundant resource for ruminants, with potentially high nutritional value. However, their extensive digestion requires a long fermentation time, achieved through large rumen and the stratification of the rumen content. Due to anatomical and physiological differences, ruminants differ in their ability to process grass leaves. Particularly, the small roe deer, with its viscous saliva and unstratified rumen content, is generally classified as a strict browser. We hypothesised that roe deer may be able to use grass leaves in some circumstances, notably when the availability of other resources declines and when the quality of grass leaves is high. We expected that (1) grass leave consumption should be higher in open landscapes than in forest habitat because grasses are more widely available and more nutritious in open landscapes and (2) grass leave consumption should increase in winter when the availability of other resources declines. We assessed grass consumption by microscopic analysis of roe deer faecal pellets collected monthly both in forest habitat and in the surrounding open landscape. We found that both the occurrence and the proportion of grass leaves in the faeces were higher in the open landscape (predicted mean proportion 0.31) than in the forest (predicted mean proportion 0.05). In addition, the proportion of grass leaves in the faeces was higher in winter and lower in spring in both forest and open landscape. We suggest that roe deer are able to use grass leaves with unusually high nutritional quality in winter in this mild climate area. This involves a certain level of digestive plasticity to efficiently digest high quality grasses and may confer nutritional benefit to individuals feeding in an open landscape. 相似文献
42.
Sandra Jose Sreevidya
S. Devi Anjana Sajeev Sosmitha Girisa Mohammed
S. Alqahtani Mohamed Abbas Abdulrahman Alshammari Gautam Sethi Ajaikumar
B. Kunnumakkara 《Bioscience reports》2023,43(3)
Farnesoid X receptor (FXR) modulates the expression of genes involved in lipid and carbohydrate homeostasis and inflammatory processes. This nuclear receptor is likely a tumor suppressor in several cancers, but its molecular mechanism of suppression is still under study. Several studies reported that FXR agonism increases the survival of colorectal, biliary tract, and liver cancer patients. In addition, FXR expression was shown to be down-regulated in many diseases such as obesity, irritable bowel syndrome, glomerular inflammation, diabetes, proteinuria, and ulcerative colitis. Therefore, development of novel FXR agonists may have significant potential in the prevention and treatment of these diseases. In this scenario, computer-aided drug design procedures can be resourcefully applied for the rapid identification of promising drug candidates. In the present study, we applied the molecular docking method in conjunction with molecular dynamics (MD) simulations to find out potential agonists for FXR based on structural similarity with the drug that is currently used as FXR agonist, obeticholic acid. Our results showed that alvimopan and montelukast could be used as potent FXR activators and outperform the binding affinity of obeticholic acid by forming stable conformation with the protein in silico. However, further investigational studies and validations of the selected drugs are essential to figure out their suitability for preclinical and clinical trials. 相似文献
43.
Yosra Mohammed Yaghmour Shraim Ala'a Said Abbas Manal Ahmad 《Journal of Medical Biochemistry》2023,42(1):35
BackgroundCOVID-19 is a new pandemic that has infected millions of people worldwide and caused a high morbidity and mortality rate. COVID-19 may have a harmful effect on organs, especially the kidneys. Aims: The main aim of our research is to study the association between the severity of COVID-19 disease and biochemical parameters related to kidney function and to investigate certain risk factors of COVID-19-associated kidney disease.MethodsA total of 174 individuals, 121 COVID-19 positive and 53 COVID-19 negative, were enrolled in this study. The relation between COVID-19 infection, severity, kidney function test, and hematological indicators were examined.ResultsThe most prominent symptoms among COVID-19 were fever (95% ) and fatigue (92%). Regarding biochemical parameters, median creatinine, MPV, and CRP were significantly higher in COVID-19 patients, whereas median eGFR, Na+, WBC, MCH, MCHC, and eosinophil percentages were significantly lower in this group. Severely infected patients were observed to have higher urea, creatinine, neutrophils, and NLR. However, median sodium, eGFR, hemoglobin, hematocrit, RBC, lymphocytes, and platelet count were significantly lower in the severe group. Urine examination of the severe group showed a significantly lower specific gravity, while urine pH, protein, and glucose were significantly higher.ConclusionsOur analysis indicates that COVID-19 infection affects kidney function, mainly creatinine level, urea, eGFR, Na+ and urine protein. Additionally, comorbidities such as older age (>65), hypertension, taking medications, and CRP (>33.55 mg/L) are considered risk factors that are more likely to contribute to kidney impairment in COVID-19 positive patients. 相似文献
44.
45.
R N Mitchell A C Shaw Y K Weaver P Leder A K Abbas 《The Journal of biological chemistry》1991,266(14):8856-8860
Membrane-bound immunoglobulin (mIg) is the antigen receptor on B lymphocytes mediating early events in antigen presentation and signal transduction. Wild-type human mIgM constructs transfected into the murine B-cell lymphoma A20 are expressed as transmembrane proteins with antigen presentation and signaling functions comparable to the endogenous mIgG2A; the transfected wild-type mIgM is internalized rapidly after anti-Ig cross-linking. Transfected constructs lacking the normal three-amino acid cytoplasmic tail are expressed exclusively as phosphatidylinositol-linked proteins, lack both antigen presentation and signal transduction functions, and are internalized slowly following anti-Ig binding. The molecular mass of the cytoplasmic tail-deleted phosphatidylinositol-linked Ig molecule is consistent with cleavage of the transmembrane residues during processing. Cytoplasmic domains may therefore regulate the mode of expression of membrane proteins and thereby influence their functional capabilities. 相似文献
46.
47.
Yasir Iftikhar Mazhar Abbas Mustansar Mubeen Muhammad Zafar-ul-Hye Faheema Bakhtawar Sonum Bashir Ashara Sajid Muhammad Asif Shabbir 《Phyton》2021,90(4):1063-1074
Tristeza is a devastating viral disease in all the citrus growing countries throughout the world and has killed millions of citrus trees in severely affected orchards. The citrus species grafted on sour orange rootstock are affected
by this disease. Predominantly, the sweet orange, grapefruit and lime trees grafted on sour orange exhibit severe
symptoms like quick decline, vein clearing, pin holing, bark scaling and degeneration leading to variable symptoms. Symptomatic expression of Citrus tristeza virus (CTV) in different hosts has been attributed to virus isolates
which are from severe to mild. Different serological and molecular assays have been deployed to differentiate the
strains of CTV. Citrus tristeza virus is diversified towards its strains on the basis of biological, serological and
molecular characterization. Phenotypic expression is due to genetic alteration and different molecular basis have
now been adopted for strain differentiation. This review will give a brief idea about the different CTV isolates,
their characterization based on nucleic acid and serological assays. Different methods along with salient features
for strain characterization has also been reviewed. This review will also open the new aspects towards formulation
of management strategies through different detection techniques. 相似文献
48.
Journal of Ichthyology - The Suez Gulf is one of the most important water bodies north of the Red Sea that contribute significantly in fish production in Egypt. The current study represents the... 相似文献
49.
Yadav Jyoti Verma Anoop Kumar Ahmad Md. Kaleem Garg Ravindra K. Shiuli Mahdi Abbas Ali Srivastava Shrikant 《Molecular biology reports》2021,48(4):3245-3252
Molecular Biology Reports - Alzheimer's disease is a common neurodegenerative disease in the elderly population and a leading cause of dementia. Genetics and environmental risk factors were... 相似文献
50.
Coral Reefs - Shallow water tropical reefs are widely threatened by anthropogenic ocean warming which sometimes exceeds their thermal tolerance limit. The majority of reefs have been currently... 相似文献