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1.
A V Rudenko V G Ma?dannik V A Pavlenko N Ia Spivak A M Romanenko E M Ishchenko L P Glebova E N Bavina 《Antibiotiki i khimioterapii͡a》1990,35(1):32-35
The effect of the type I interferon on the development and process of experimental pyelonephritis caused by E. coli was studied on mice weighing 12 to 14 g. Interferon was administered intraperitoneally in a dose of 1000 units on days 3 and 7 of the disease. It was shown that the administration of the type I interferon to the mice with experimental pyelonephritis promoted rapid elimination of bacteria from the kidneys, prevented their penetration to the contralateral (intact) kidney, prevented marked macro- and microscopic damages in the kidneys, lowered the intensity of the inflammatory reaction, and increased the phagocytic activity of neutrophils and the number of the E-rosette-forming lymphocytes in the thymus. The data provided experimental grounding for clinical trials of interferon preparations in treatment of bacterial pyelonephritis. 相似文献
2.
Antibiotic salvin obtained from Salvia officinalis has been studied for its effect on the growth and ultrastructure of Staphylococcus aureus 209P. The antibiotic in the sub-bacteriostatic concentration considerably elongates the lag-phase (up to 11-12 h) exerting no significant effect on the growth rate of the staphylococcus population as well as it prolongs duration of the exponential phase. The analysis of electronograms of staphylococcus cells subjected to the action of salvin in the concentrations similar to the minimal inhibitory concentration (MIC), has revealed the cell thinning, inhibition and destruction of the division. The introduction of 5MIC antibiotic into the exponentially grown culture made a cell wall considerably thinner, destructing its external layer; the number of lyzed cells sharply increased. The appearance of bodies not described previously with a membrane envelope and ribosomes as well as of mesosomal structures was observed. 相似文献
3.
Elemental distribution in striated muscle and the effects of hypertonicity: Electron probe analysis of cryo sections 总被引:15,自引:4,他引:11 下载免费PDF全文
A method of rapid freezing in supercooled Freon 22 (monochlorodifluoromethane) followed by cryoultramicrotomy is described and shown to yield ultrathin sections in which both the cellular ultrastructure and the distribution of diffusible ions across the cell membrane are preserved and intracellular compartmentalization of diffusabler ions can be quantitated. Quantitative electron probe analysis (Shuman, H., A.V. Somlyo, and A.P. Somlyo. 1976. Ultramicros. 1:317-339.) of freeze-dried ultrathin cryto sections was found to provide a valid measure of the composition of cells and cellular organelles and was used to determine the ionic composition of the in situ terminal cisternae of the sarcoplasmic reticulum (SR), the distribution of CI in skeletal muscle, and the effects of hypertonic solutions on the subcellular composition if striated muscle. There was no evidence of sequestered CI in the terminal cisternae of resting muscles, although calcium (66mmol/kg dry wt +/- 4.6 SE) was detected. The values of [C1](i) determined with small (50-100 nm) diameter probes over cytoplasm excluding organelles over nuclei or terminal cisternae were not significantly different. Mitochondria partially excluded C1, with a cytoplasmic/ mitochondrial Ci ratio of 2.4 +/- 0.88 SD. The elemental concentrations (mmol/kg dry wt +/- SD) of muscle fibers measured with 0.5-9-μm diameter electron probes in normal frog striated muscle were: P, 302 +/- 4.3; S, 189 +/- 2.9;C1, 24 +/- 1.1;K, 404 +/- 4.3, and Mg, 39 +/- 2.1. It is concluded that: (a) in normal muscle the "excess CI" measured with previous bulk chemical analyses and flux studies is not compartmentalized in the SR or in other cellular organelles, and (b) the cytoplasmic C1 in low [K](0) solutions exceeds that predicted by a passive electrochemical distribution. Hypertonic 2.2 X NaCl, 2.5 X sucrose, or 2.2 X Na isethionate produced: (a) swollen vacuoles, frequently paired, adjacent to the Z lines and containing significantly higher than cytoplasmic concentrations of Na and Cl or S (isethionate), but no detectable Ca, and (b) granules of Ca, Mg, and P = approximately (6 Ca + 1 Mg)/6P in the longitudinal SR. It is concluded that hypertonicity produces compartmentalized domains of extracellular solutes within the muscle fibers and translocates Ca into the longitudinal tubules. 相似文献
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Natalia Poplavskaya Anna Bannikova Karsten Neumann Marina Pavlenko Irina Kartavtseva Yuriy Bazhenov Pavel Bogomolov Alexey Abramov Alexey Surov Vladimir Lebedev 《Journal of Zoological Systematics and Evolutionary Research》2019,57(3):679-694
Striped hamsters (Cricetulus barabensis sensu lato) represent a complex of chromosomally distinct allopatric lineages/taxa of either species or subspecies rank. They are widely distributed across the steppes of eastern and central Palearctic. Phylogenetic analysis of cytochrome b gene sequences based on 496 specimens from 112 localities revealed five well‐supported lineages divergent at 2%–4%. Two of them correspond to “griseus” (2n = 22) and “pseudogriseus” (2n = 24) karyomorphs and are placed as sister taxa. The “barabensis” (2n = 20) karyomorph is represented by three other branches and appears non‐monophyletic. All mtDNA lineages are distributed allopatrically or parapatrically; no indications of gene flow between populations of different chromosomal races were found. The results of the molecular clock analysis suggest that the main lineages diverged in the late Middle Pleistocene. The inferred evolutionary scenario implies that the common ancestor of the recent lineages belonged to the 2n = 20 karyomorph and originated in the eastern part of the contemporary range. 相似文献
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Banetskaia NV Pavlenko VS Amvros'ev AP 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2003,43(6):613-617
It was shown that the prolonged low-dose irradiation (up to 0.6 Gy) of the immature ovocytes of young rats (21-28 days old) caused delay of development of preimplantation embryos after fertilization of ovicells. 相似文献
8.
The possibility of monooxygenase enzymes biomimetic construction models with the use of polynuclear manganese complexes was shown. It was demonstration that benzene is oxidized by polynuclear manganese complex [Mn12O12(CH3CO2)16(H2O)4] in acetonitrile solution at room temperature and atmospheric pressure yielding phenol with the selectivity more than 80%. It was determined that the addition of air oxygen as the reoxidizer to the reaction mixture didn't transfer the reaction into the catalytic mode. 相似文献
9.
The peculiarities of the formation of colonies of dimorphous epilithic fungus Phaeococcomyces de Hoog isolated from marble were studied. The data obtained can be used for modeling the formation of colonies of dimorphous microscopic fungi. 相似文献
10.
Sixteen of 28 possible biotypes of C. elongatoides-taenia s.lato (C. taenia, C. tanaitica, C. species-1) have been found in Ukrainian waters. Presumably, the biotypes of C. aff. melanoleuca-tanaitica has also been identified. The share of polyploids among Cobitis on average was 65%, where males made up less than 1% with the same ratio among tri- and tetra-polyploids. The absence of amphydiploidy and presence of individuals with recombinant genotype and abnormal electrophoretic specters, whose frequency sometimes is considerable, are attracting increasing interest. There are two centers of polyploid biotypes creation: southern (the Lower Danube) and northern (the Upper Danube, Oder, and Rhine). The C. taenia and C. species-1 type, which is typical for the northwestern basins of Ukraine, participates in the formation of polyploids in the Rhine alongside with C. elongatoides and C. tanaitica. It is determined that biotypes (C. 2(3) elongatoidestanaitica, C. elongatoides-2(3) tanaitica) in comparison with biotypes whose genome includes the chromosome set of C. taenia are limited in distribution towards the East. This is due to the hybridization of females from these biotypes with males of C. taenia afflicted by genetic instability and reduced viability of posterity. 相似文献