Too early? on the apparent conflict of astrobiology and cosmology

An interesting consequence of the modern cosmological paradigm is the spatial infinity of the universe. When coupled with naturalistic understanding of the origin of life and intelligence, which follows the basic tenets of astrobiology, and with some fairly incontroversial assumptions in the theory of observation selection effects, this infinity leads, as Ken Olum has recently shown, to a paradoxical conclusion. Olum's paradox is related, to the famous Fermi's paradox in astrobiology and “SETI” studies. We, hereby, present an evolutionary argument countering the apparent inconsistency, and show how, in the framework of a simplified model, deeper picture of the coupling between histories of intelligent/technological civilizations and astrophysical evolution of the Galaxy, can be achieved. This strategy has consequences of importance for both astrobiological studies and philosophy.     

Subcellular localization of Nm23/NDPK A and B isoforms: a reflection of their biological function?

ABCG2 is a half-transporter initially described in multidrug-resistant cancer cells and lately identified as an important factor in the pharmacokinetics of its substrates. Q141K is by far the most intensively studied single nucleotide polymorphism of ABCG2 with potential clinical relevance. Here we used stably transfected HEK cells to study the Q141K polymorphism together with the deletion of amino acids 315–316, which were recently reported to coexist in two cancer cell lines (A549 and SK-OV-3). Functional studies confirmed our previous report that when normalized to surface expression, Q141K has impaired transport of mitoxantrone. This result was extended to include the ABCG2-specific substrate pheophorbide a. While we found no functional consequence of deleting amino acids 315 and 316, we did find that the deletion mutant is no longer recognized by the BXP-21 antibody. We conclude that amino acids 315 and 316 form part of the epitope for the BXP-21 antibody.     

Flowering ofin vitro grown spinach shoots in the presence of the Herbicide Sandoz 9789

Stem tips ofSpinacia oleracea were isolated and grown in sterile culture, with Sandoz 9789 added to the medium. Although the herbicide provoked a complete loss of all chloroplast pigments, developed shoots were able to flower, in response to long days; in short days flowering was inducible by adding gibberellins. Sandoz 9789 decreased the elongation of stems by up to 30%; the percentage of flowering plants in culture was also decreased. However, among those plants that flowered, the majority were male, so that Sandoz 9789 produced a shift of the sex ratio toward maleness.     

The behaviour of the shoot apical meristem inChenopodium rubrum under conditions non-inductive for flowering

The results of different photoperiodic treatments preventing flowering and representing the control vegetative treatments in the studies of floral induction and differentiation were studied inChenopodium rubrum seedlings. A fully vegetative growth pattern of the meristem was maintained only in continuous light or after a photoperiodic treatment which consisted in a 15 min light break of the 8 h dark periods which themselves are a threshold for flowering inChenopodium. Light breaks applied to 10 h and longer dark periods did not prevent the changes resembling the early events of transition to flowering. Disappearance of zonal pattern, stimulation of apical growth, precocious initiation of leaf primordia and weakening of apical dominance have been observed. Flower formation did not follow. This work was supported by a grant from the Scientific Research Fund of SR Serbia.     

Relationship between osteology and aquatic locomotion in birds: determining modes of locomotion in extinct Ornithurae

The evolutionary history of aquatic invasion in birds would be incomplete without incorporation of extinct species. We show that aquatic affinities in fossil birds can be inferred by multivariate analysis of skeletal features and locomotion of 245 species of extant birds. Regularized discriminant analyses revealed that measurements of appendicular skeletons successfully separated diving birds from surface swimmers and flyers, while also discriminating among different underwater modes of swimming. The high accuracy of this method allows detection of skeletal characteristics that are indicative of aquatic locomotion and inference of such locomotion in bird species with insufficient behavioural information. Statistical predictions based on the analyses confirm qualitative assessments for both foot‐propelled (Hesperornithiformes) and wing‐propelled (Copepteryx) underwater locomotion in fossil birds. This is the first quantitative inference of underwater modes of swimming in fossil birds, enabling future studies of locomotion in extinct birds and evolutionary transitions among locomotor modes in avian lineage.