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Marisa Liliana Fernández Maria Elena Marson Juan Carlos Ramirez Guido Mastrantonio Alejandro Gabriel Schijman Jaime Altcheh Adelina Rosa Riarte Facundo García Bournissen 《Memórias do Instituto Oswaldo Cruz》2016,111(3):218-221
Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in
children in all stages, but it is controversial in chronically infected adults. We
report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas
disease treated with the new BNZ formulation (ABARAX®) in doses between
2.5-5.5 mg/Kg/day. All but one patient had plasmatic BNZ concentrations within the
expected range. All patients finalised treatment with nondetectable
Trypanosoma cruziquantitative polymerase chain reaction, which
remained nondetectable at the six month follow-up. Our data suggests parasitological
responses with the new BNZ and supports the hypothesis that treatment protocols with
lower BNZ doses may be effective. 相似文献
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Industrial biotechnology employs the controlled use of microorganisms for the production of synthetic chemicals or simple
biomass that can further be used in a diverse array of applications that span the pharmaceutical, chemical and nutraceutical
industries. Recent advances in metagenomics and in the incorporation of entire biosynthetic pathways into Saccharomyces cerevisiae have greatly expanded both the fitness and the repertoire of biochemicals that can be synthesized from this popular microorganism.
Further, the availability of the S. cerevisiae entire genome sequence allows the application of systems biology approaches for improving its enormous biosynthetic potential.
In this review, we will describe some of the efforts on using S. cerevisiae as a cell factory for the biosynthesis of high-value natural products that belong to the families of isoprenoids, flavonoids
and long chain polyunsaturated fatty acids. As natural products are increasingly becoming the center of attention of the pharmaceutical
and nutraceutical industries, the use of S. cerevisiae for their production is only expected to expand in the future, further allowing the biosynthesis of novel molecular structures
with unique properties. 相似文献