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21.
Ahmed I Cosen-Binker LI Leung YM Gaisano HY Diamant NE 《Biochemical and biophysical research communications》2007,358(3):789-795
The SNARE protein syntaxin 1A (Syn1A) is known to inhibit delayed rectifier K(+) channels of the K(v)1 and K(v)2 families with heterogeneous effects on their gating properties. In this study, we explored whether Syn1A could directly modulate K(v)4.3, a rapidly inactivating K(v) channel with important roles in neuroendocrine cells and cardiac myocytes. Immunoprecipitation studies in HEK293 cells coexpressing Syn1A and K(v)4.3 revealed a direct interaction with increased trafficking to the plasma membrane without a change in channel synthesis. Paradoxically, Syn1A inhibited K(v)4.3 current density. In particular, Syn1A produced a left-shift in steady-state inactivation of K(v)4.3 without affecting either voltage dependence of activation or gating kinetics, a pattern distinct from other K(v) channels. Combined with our previous reports, our results further verify the notion that the mechanisms involved in Syn1A-K(v) interactions vary significantly between K(v) channels, thus providing a wide scope for Syn1A modulation of exocytosis and membrane excitability. 相似文献
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23.
XING LI GUO HONG XIA JIAN FEI FANG HUANG LI HE GUO Institute of Biochemistry Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China 《Cell research》2001,(2)
INTRODUCTIONGal a(1, 3) Gal (gal epitope) is a carbohydrate epitope, which is produced in large amounton the cells of pigs, mice and New World monkey(monkey of South America) by the glycosylationenzyme G alal 1 ) 4G IcNAc3- a- D- galactosyltransferase[or(1, 3)GT; EC2.4.1.511111. This enzyme is active in the Golgi appaxatus of cells and transfers galactose from the sugandonor uridine diphoSphate galactose (UDP-galactose) to the acceptor Nacetyllactosamine residue (Galaal-4GlcNAc-R… 相似文献
24.
李永全 郑克勤 周汝滨 潘超仁 廖霞 陈小萍LI Yong-quan ZHENG Ke-qin ZHOU Ru-bin PAN Chao-ren LIAO Xia CHEN Xiao-ping 《遗传》1999,21(6):10-185
在2 703例遗传咨询门诊病例中检出9号染色体臂间倒位21例,将本组inv(9)的频率与普通群体inv(9)的频率作比较,并通过对伴有其它性状的inv(9)家系的分析,讨论了inv(9)的遗传效应问题。
Abstract: Twenty one cases of pericentric inversion of chromosome 9 were found in 2703 patients asking genetic counseling. The percentage of inv(9) in this group was compared with that in normal population. Two special pedigrees with inv(9) were analyzed and the genetic effects of inv(9) were discussed. 相似文献
25.
To identify salt stress-responsive genes, we constructed a cDNA library with the salttolerant rice cultivar, Lansheng. About 15000 plasmids were extracted and dotted on filters with Biomeck 2000 HDRT system or by hand. Thirty genes were identified to display altered expression levels responding to 150 mmol/L NaCl. Among them eighteen genes were up-regulated and the remainders downregulated. Twenty-seven genes have their homologous genes in GenBank Databases. The expression of twelve genes was studied by Northern analysis. Based on the functions, these genes can be classified into five categories, including photosynthesis-related gene, transportrelated gene, metabolismrelated gene, stress-or resistancerelated gene and the others with various functions. The results showed that salt stress influenced many aspects of rice growth. Some of these genes may play important roles in plant salt tolerance. 相似文献
26.
Li YANG Jiang CHEN Catherine C. Y. CHANG Xin-Ying YANG Zhen-Zhen WANG Ta-Yuan CHANG and Bo-Liang LI* State Key Laboratory of Molecular Biology Institute of Biochemistry Cell Biology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences Shanghai China Department of Biochemistry Dartmouth Medical School Hanover NH USA 《Acta biochimica et biophysica Sinica》2004,(4)
Acyl-coenzyme A:cholesterol acyltransferase (ACAT)is an integral membrane protein, which is mainly locatedin rough endoplasmic reticulum (ER), and is responsiblefor catalyzing the intracellular formation of cholesterylester from cholesterol and long-chain fatty acyl-coenzymeA [1,2]. Human ACAT1 cDNA K1 was firstly cloned andfunctionally expressed in 1993 [3]. Further studies withspecific anti-ACAT1 antibody (DM10) illustrated that onemajor 50 kD ACAT1 protein was expressed in various… 相似文献
27.
LI Zhengxi Jing-Jiang ZHOU SHEN Zuorui & Lin FIELD .Department of Entomology China Agricultural Univeristy Beijing China .Biological Chemistry Division Rothamsted Research Harpenden Herts. AL JQ UK Correspondence should be addressed to Li Zhengxi 《中国科学:生命科学英文版》2004,47(6):567-576
~~Identification and expression profiling of putative odorant-binding proteins in the malaria mosquitoes, Anopheles gambiae and A. arabiensis1. Curtis, C. F., Introduction 1: An overview of mosquito biology, behaviour and importance, in Olfaction in Mosquito-Host Interactions (eds. Bock, G. R.. Cardew, G.), New York: Wiley, 1996, 3-7.
2. Nighom, A., Hildebrand. J. G.. Dissecting the molecular mechanisms of olfaction in a malaria-vector mosquito, PNAS, 2002, 99(3): 1113-… 相似文献
28.
Dan WANG Jinlong REN Ke JIANG Wei WU Changjun PENG Hussam ZAHER Dechun JIANG Jiatang LI 《亚洲两栖爬行动物研究(英文版)》2022,(3):180-189
Pareidae and Dipsadidae, two independently evolved taxa in the Serpentes lineage, both feed exclusively on terrestrial mollusks(snails and slugs). Dipsadid snakes developed hypertrophic infralabial glands in their lower jaw, which are thought to be associated with their specialized feeding behaviors. However, whether a similar gland exists in pareid snakes is unknown. In this study, we examined the morphological characteristics of the infralabial glands in Pareas berdmorei and Pareas chinensis b... 相似文献
29.
China is one of the countries in the world with therichest species biodiversityinfreshwater ecosystem.How-ever,duetothe rapid economic growthandthe continuingincrease of human disturbances and destructions of aquatichabitats,the biodiversity of freshwater ecosystemsis dras-tically declining.Waterbodies become more and more“deserted”of sensitive species.Water areas are reduced,fragmentized,and changed in their hydrodynamics(i.e.damming),causing changes in sedimentation and otherchanges.Forinstance,the area o... 相似文献
30.
Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and
the immune defense system. Additionally, cell fusions participate in tissue repair and may be important to cancer development
and progression. A large number of factors appear to regulate cell fusions, including receptors and ligands, membrane domain
organizing proteins, proteases, signaling molecules and fusogenic proteins forming alpha-helical bundles that bring membranes
close together. The syncytin family of proteins represent true fusogens and the founding member, syncytin-1, has been documented
to be involved in fusions between placental trophoblasts, between cancer cells and between cancer cells and host cells. We
review the literature with emphasis on the syncytin family and propose that syncytins may represent universal fusogens in
primates and rodents, which work together with a number of other proteins to regulate the cell fusion machinery. 相似文献