排序方式: 共有443条查询结果,搜索用时 15 毫秒
61.
穆玉姣 《微生物学免疫学进展》2008,36(3)
整合子和金属β-内酰胺酶(MBL)使铜绿假单胞菌的耐药机制更加复杂,给临床的抗感染治疗带来了较大的困难。I类整合子(IntI)的结构与其在铜绿假单胞菌四类金属酶的耐药基因中的传播作用是临床关注的问题之一。 相似文献
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ZHANG Jinzhu 《中国科学:生命科学英文版》1997,40(5):488-495
Changes of sodium ionic concentration of human erythrocytes applied to pulsed electrical field (PEF) were studied by using shift reagent and NMR spectroscopy. The results show that the concentration of intracellular Na+ increases with the increasing intensity of PEF when the erythrocytes are applied to PEF with higher intensities. The relationship between intracellular Na concentrations and the intensities of PEF does not follow linear or exponen-tial behavior. As the intensities increase, the intracellular Na+concentrations increase even faster by an exponential curve. However under effects of PEF at lower intensities, intracellular Na+ concentration decreases. Ouabain can in-hibit the decrease of intracellular Na concentration, and the inhibition increases with the increasing concentration of ouabain, suggesting that Na+ , K+ -ATPase on cell membrane can be activated by PEF at lower intensities. Direct measurement of activities of the enzyme by using Malachite green method has confirmed this observation. Cell perme-abilities to ions, activation of enzymes by electrical fields and transmission of physical signals like PEF across cell mem-branes are discussed. 相似文献
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《生物技术评论》(CriticalReviewinBiotechnology)该刊是美国著名的出版公司———CRC出版有限责任股份公司出版的系列期刊之一 ,原名为CRCCriticalReviewinBiotechnology ,是 1983年创刊的。该刊为季刊 ,每年 1卷 ,每卷末期附带全年作者索引和主题索引。该刊收录的文章涉及生物技术的各个领域 ,包括与食品和饮料工业、燃料生产、化学及制药业、废物处置以及其它与社会、环境和经济领域密切相关的从发酵技术到遗传操作和蛋白质工程的技术。该刊刊登世界不同地区的技术现… 相似文献
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陈欣 《国外医学:分子生物学分册》2007,4(1):45-49
造血干细胞(hematopoietic stem cell,HSC)位于骨髓的造血微环境即龛(niche)中,它们与龛内特定的细胞相互作用以调节其自我更新和定向分化。研究发现,骨髓中的成骨细胞和内皮细胞与造血干细胞关系密切,分别构成了HSC龛中的成骨龛和血管龛,其中成骨龛维持静态的HSC微环境,而血管龛调控HSC的增殖、分化和动员等行为。对骨髓HSC龛的研究为将来临床治疗血液系统相关疾病提供了新的思路。 相似文献
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XUSHIXIONG 《Cell research》1993,3(1):93-101
The pattern of change of the microtubule cytoskeleton of the root-tip cells of rice during mitosis was studied using immunofluorescence technic and confocal laser scanning microscopy. All the major stages of ceil division including preprophase, prophase, metaphase, anaphase and telophase were observed. The most significant finding was that in the preprophase cells microtubules radiating from the nuclear surface to the cortex were frequently seen. During development these microtubules became closely associated with the preprophase band and prophase spindie indicating that the microtubules radiating from the nuclear surface, the preprophase band and the prophazc spindle were structurally and functionally closely related to each other. Granule-like anchorage sites for the radiating microtubules at the muclear surface were often seen and the possibility that these gramle-like anchorage sites might represent the microtubule organizing centres was discussed. 相似文献
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系统生物学采用系统理论和实验生物技术、计算机数学模型等方法整合研究动态生物系统网络.生物系统的结构理论和生物系统技术,研究基因组——生物体复杂系统与细胞分子网络系统的动态结构发生与进化,分析基因组的逻辑程序和人工设计原理.细胞信号传导、基因调控网络、代谢反应链和基因反馈调控的自组织化人工设计和基因、基因链、基因组人工合成等系统生物工程开发,可用于复杂疾病机理分析、药物分子筛选和转基因表达系统的生物反应器、纳米生物计算机等. 相似文献
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生长因子颗粒素蛋白前体(progranulin, PGRN)广泛存在于动物和植物组织中.研究证明,哺乳动物的PGRN是一个多功能分子,在组织/器官发育、细胞分化、肿瘤发生发展、炎症应答以及神经退行性疾病中均具有重要的作用.PGRN发挥生物学功能需要和多种结合蛋白相互结合,例如sortilin、Toll样受体9(TLR9)、肿瘤坏死因子受体(TNFR)及分泌性淋巴细胞蛋白酶抑制因子(SLPI)等. 本文将对PGRN的结合受体和生物学功能进行综述. 相似文献
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