人胚绒毛组织微核测定法的建立及其在评价吸烟致突性研究中的应用

目前采用的动物骨髓细胞和人外周血淋巴细胞的快速检测DNA损伤的微核测定法,均不能反映环境因子对人类子代的致突变性。用人胚绒毛组织微核直接检测环境因子的致突变性研究,未见有国内外报道。为此,我们通过对妊娠10周内的507例人工流产的绒毛组织微核测定,显示人胚绒毛组织微核细胞率正常值为0.69±0.74‰(0—4.5‰,每例观察2000个间期细胞);女方不吸烟其丈夫吸烟的被动吸烟组和女方无主被动吸烟组分别为0.753±0.693‰和0.583±0.761‰,二者有显著性统计学意义(P=0.041);男     

Erratum to: Coarse root spatial distribution determined using a ground-penetrating radar technique in a subtropical evergreen broad-leaved forest, China

Erratum to:Science China Life Sciences,November 2013 Vol.56 No.11:1038–1046doi:10.1007/s11427-013-4560-7The legend of Figure 1 should be as follows:Figure 1 Distribution map of 15 subplots at three types of habitats(ridge,slope and valley)     

Quantitative assessment of acute kidney injury by noninvasive arterial spin labeling perfusion MRI:a pilot study

The kidneys are essential for maintaining homeostasis,are responsible for the reabsorption of water,glucose and amino acids,and filter the blood by removing waste.Acute kidney injury(AKI) is a syndrome characterized by the rapid loss of renal excretory function and the accumulation of end metabolic products of urea and creatinine.AKI is associated with the later development of chronic kidney disease and end-stage kidney disease,and may eventually be fatal.Early diagnosis of AKI and assessments of the effects of treatment,however,are challenging.The pathophysiological mechanism of AKI is thought to be the imbalance between oxygen supply and demand in the kidneys.We have assessed the ability of arterial spin labeling(ASL) perfusion magnetic resonance imaging(MRI),without the administration of contrast media,to quantify renal blood flow(RBF) non-invasively.We found that RBF was significantly lower in AKI patients than in healthy volunteers.These results suggest that ASL perfusion MRI,a noninvasive measurement of RBF,may be useful in the early diagnosis of AKI.