Baculoviruses as Vectors in Mammalian Cells

The Baculoviridae are a large family of enveloped DNA viruses exclusively pathogenic to arthropods. Baculoviruses have been extensively used in insect cell-based recombinant protein expression system and as biological pesticides. They have been deomostrated to be safe to mammals, birds and fish. Recently, baculoviruses has been shown to transduce different mammalian cells in spite of the fact that they cannot replicate in mammalian cells (11, 73, 76). This has resulted in the development of baculoviruses as mammalian expression systems and even as vestors for gene therapy.     

石蒜碱通过激活AMPK通路和下调MMP9促进雪旺细胞自噬改善神经功能

糖尿病周围神经病变(DPN)是糖尿病最常见的并发症,也是最常见的神经系统疾病。DPN患者有多种表现,包括大神经纤维损伤引起的感觉丧失和肌肉无力,小神经纤维损伤引起的感觉迟钝、疼痛、麻木和植物神经症状。严重时,DPN还会导致剧烈疼痛和皮肤溃疡,甚至威胁患者生命。然而目前尚无批准用于治疗DPN的药物。     

Antiviral therapy and outcomes of patients with pneumonia caused by influenza A pandemic (H1N1) virus

Background

There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset.

Methods

During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models.

Results

920 adults and 541 children with pneumonia who didn''t receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy (18.2%) than those with who received oseltamivir ≤ 2days (2.9%), between 2–5 days (4.6%) and >5 days after illness onset (4.9%), p<0.01. A similar trend was observed in pediatric patients. Cox regression showed that at 60 days after symptoms onset, 11 patients (10.8%) who did not receive antivirals died versus 4 (1.8%), 18 (3.3%), and 23 (3.7%) patients whose oseltamivir treatment was started ≤ 2days, between 2–5days, and >5 days, respectively. For males patients, aged ≥ 14 years and baseline PaO₂/FiO₂<200, oseltamivir administration reduced the mortality risk by 92.1%, 88% and 83.5%, respectively. Higher doses of oseltamivir (>3.8 mg/kg/d) did not improve clinical outcome (mortality, higher dose 2.5% vs standard dose 2.8%, p>0.05).

Conclusions

Antiviral therapy might reduce mortality of patients with pH1N1 pneumonia, even when initiated more than 48 hours after onset of illness. Greater protective effects might be in males, patients aged 14–60 years, and patients with PaO₂/FiO₂<200.     

广西人工栽培铁皮石斛内生菌根的研究

通过光学生物显微镜及Qwin图像分析系统,对人工繁育栽培的铁皮石斛各生长期植株的内生菌根进行了观察分析。结果表明:铁皮石斛具有典型的内生菌根;铁皮石斛根内共生菌不是其原有的,而是通过栽培基质传与铁皮石斛的根而共生。被真菌侵染的区域大,其植株生长茂盛,真菌对铁皮石斛的生长发育可能有促进的作用。     

QUANTITATIVE ANALYSIS IN THE RESEARCH OF TEACHING

TheauthorconslstentlythlnkthatagreatdealofinfromationisIncludedintbescoreofstudent’sexamination,whichcanbeusedInthequantitativeanalysisofteachingandstudyingproblemsonmanyaspects．Soseveralstatlstlca！methodshavebeenusedInthestudyofteachingactivitybythea…     

第十五届十三省（市）光学学术会议征文通知

受十三省(市)光学学会的委托,第十五届十三省(市)光学学术会议拟于2006年8月中旬在山西五台山召开(太原报到),会议由中国光学学会为支持单位,山西省光学学会为主办单位,山西大学、山西长城微光器材股份有限公司、太原理工大学、中北大学为承办单位,上海市红外与遥感学会、福建省光学学会、湖北省光学学会为协办单位。现将征文具体事宜通知如下:1.征文范围:(1)基础光学(2)量子光学(3)光电子技术(4)激光技术(5)红外材料与器件及各种红外技术的应用(6)光纤通信技术(7)光纤传感技术与应用(8)遥感技术及其应用2.征文要求:(1)论文的正文字数以3000…     

一个生机勃勃的国家开放实验室——复旦大学国家遗传工程重点实验室介绍

为贯彻我国科技发展方针,适应我国经济和科技的日益发展,作为科学技术的储备,加强基础研究和应用研究,促进高技术领域的探索,为获得高水平的科技成果,培养优秀人才,1984年7月,国家计委、国家科委和国家教委组织全国有关专家对在复旦大学建立“遗传工程重点实验室”进行了全面、认真地论证。与会专家一致认为:“复旦大学遗传所有20多     

Sea Urchin Spines as a Model-System for Permeable, Light-WeightCeramics with Graceful Failure Behavior. PartⅡ.Mechanical Behavior of Sea Urchin Spine Inspired Porous Aluminum Oxide Ceramics under Compression

Sea urchin spines were chosen as a model system for biomimetic ceramics obtained using starch-blended slip casting.Porous alumina ceramics with cap-shaped layers with different alternating porosities were found to have superior fracturebehavior under bulk compression compared to ceramics with uniform porosity.They fail in a cascading manner,absorbing highamounts of energy during extended compression paths.The porosity variation in an otherwise single phase material mimicks thearchitectural microstructure design of sea urchin spines of Heterocentrotus mammillatus,which are promising model materialsfor impact protection.