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31.
Constantí Stefanescu Ferran Páramo Susanne Åkesson Marta Alarcón Anna Ávila Tom Brereton Jofre Carnicer Louis F. Cassar Richard Fox Janne Heliölä Jane K. Hill Norbert Hirneisen Nils Kjellén Elisabeth Kühn Mikko Kuussaari Matti Leskinen Felix Liechti Martin Musche Eugenie C. Regan Don R. Reynolds David B. Roy Nils Ryrholm Heiko Schmaljohann Josef Settele Chris D. Thomas Chris van Swaay Jason W. Chapman 《Ecography》2013,36(4):474-486
Long‐range, seasonal migration is a widespread phenomenon among insects, allowing them to track and exploit abundant but ephemeral resources over vast geographical areas. However, the basic patterns of how species shift across multiple locations and seasons are unknown in most cases, even though migrant species comprise an important component of the temperate‐zone biota. The painted lady butterfly Vanessa cardui is such an example; a cosmopolitan continuously‐brooded species which migrates each year between Africa and Europe, sometimes in enormous numbers. The migration of 2009 was one of the most impressive recorded, and thousands of observations were collected through citizen science programmes and systematic entomological surveys, such as high altitude insect‐monitoring radar and ground‐based butterfly monitoring schemes. Here we use V. cardui as a model species to better understand insect migration in the Western Palaearctic, and we capitalise on the complementary data sources available for this iconic butterfly. The migratory cycle in this species involves six generations, encompassing a latitudinal shift of thousands of kilometres (up to 60 degrees of latitude). The cycle comprises an annual poleward advance of the populations in spring followed by an equatorward return movement in autumn, with returning individuals potentially flying thousands of kilometres. We show that many long‐distance migrants take advantage of favourable winds, moving downwind at high elevation (from some tens of metres from the ground to altitudes over 1000 m), pointing at strong similarities in the flight strategies used by V. cardui and other migrant Lepidoptera. Our results reveal the highly successful strategy that has evolved in these insects, and provide a useful framework for a better understanding of long‐distance seasonal migration in the temperate regions worldwide. 相似文献
32.
Carlos Pérez-Medina Niral Patel Mathew Robson Mark F. Lythgoe Erik Årstad 《Bioorganic & medicinal chemistry letters》2013,23(18):5170-5173
In vivo imaging of voltage-gated sodium channels (VGSCs) can potentially provide insights into the activation of neuronal pathways and aid the diagnosis of a number of neurological diseases. The iminodihydroquinoline WIN17317-3 is one of the most potent sodium channel blockers reported to date and binds with high affinity to VGSCs throughout the rat brain. We have synthesized a 125I-labeled analogue of WIN17317-3 and evaluated the potential of the tracer for imaging of VGSCs with SPECT. Automated patch clamp studies with CHO cells expressing the Nav1.2 isoform and displacement studies with [3H]BTX yielded comparable results for the non-radioactive iodinated iminodihydroquinoline and WIN17317-3. However, the 125I-labeled tracer was rapidly metabolized in vivo, and suffered from low brain uptake and high accumulation of radioactivity in the intestines. The results suggest that iminodihydroquinolines are poorly suited for tracer development. 相似文献
33.
Keith W. Larson Miriam Liedvogel Staffan Bensch Susanne Åkesson Leonard I. Wassenaar Keith A. Hobson 《Journal of avian biology》2013,44(6):561-566
We present a comparison of feather stable isotope (δ13C, δ15N) patterns representing the habitat and diet conditions for two subspecies of willow warblers Phylloscopus trochilus that breed in parapatry, but winter in different regions of sub‐Saharan Africa. Previous analyses have shown that on average winter moulted innermost primaries (P1) show subspecific differences in δ15N values, although individuals show substantial variation for both δ13C and δ15N within the subspecies. We examined whether corresponding variation in the timing of the winter moult, as reflected by consistent intra‐wing correlations for individual's δ13C and δ15N values, could explain some of the previously observed isotopic variation. Further, differential subspecific adaptations to winter precipitation patterns across Africa might result in a variable degree of site fidelity or itinerancy during moult. We found no consistent trend in isotopic values from innermost to outermost primaries, thus inter‐individual variation in the timing of moult does not explain the subspecific isotopic variation for P1. Patterns in wing feather δ13C and δ15N values indicated that 41% of the individuals from both subspecies shifted their diet or habitats during winter moult. Importantly, despite well‐documented itinerancy in willow warblers during the winter, 59% of the individuals had feather isotope values consistent with stable use of habitats or diets during winter moult. Repeatability analyses suggest that individuals of both subspecies initiate moult in similar habitats from year‐to‐year while feeding on isotopically similar diets. 相似文献
34.
35.
The european lynx (Lynx lynx) might be expected to have a high intake of radiocaesium in the parts of Sweden where the main prey of the lynx, namely reindeer and roe deer have high activity concentrations of radiocaesium because of high ground deposition. We have measured 137Cs in muscle samples from 733 lynx during 1996–2003. The aim was to quantify the extent to which radiocaesium is transferred from fallout deposition to lynx, to test whether the transfer was higher in areas where there are reindeer present, to see if there was any decline in radiocaesium over time, and to calculate the radiation dose to lynx. Most samples were collected in central and northern Sweden during January–April. Activity concentrations in lynx varied from 13 Bq kg–1 to about 15 kBq kg–1 fresh weight, with the highest value corresponding to a radiation dose at 18 mGy/year. Aggregated transfer coefficients (Tag), calculated by dividing the 137Cs activity concentration in lynx muscle by the average ground deposition (total from Chernobyl and nuclear weapon tests) within a 50 km radius around the location of the lynx, varied from 0.004 to 1.3 m2 kg–1 and were significantly higher within the reindeer herding area than outside. The concentration ratio (CR) for lynx/reindeer was 2.6 on average, whilst the average for lynx/roe deer outside the reindeer herding area was lower at 1.3. Based on these results, a CR of around 2 could be considered representative for the general ratio between predator and prey. A long-term decline of radiocaesium in prey species was reflected in lynx, with an effective half-life of 7 years from 1996 to 2003. The study shows that the accumulation of radiocaesium in predators, especially predators of reindeer, makes them more vulnerable to high radiocaesium deposition than most other wild species. 相似文献
36.
Albertsson PA 《Photosynthesis research》2003,76(1-3):217-225
The role of photosynthetic pigments in the development of separation methods in biochemistry during the period 1900-1980 is described beginning with M. Tswett who introduced separation of chlorophylls and carotenoids on columns and coined the term chromatography in 1906. In Uppsala, T. Svedberg developed the ultracentrifuge in the 1920s. A. Tiselius improved electrophoresis in the 1930s and developed chromatography of proteins in the 1940s and 1950s. Others of 'The Uppsala school in separation science' include J. Porath, P. Flodin and S. Hjertén who further developed various gel chromatographic methods. Hjertén introduced free zone electrophoresis in narrow tubes, a forerunner of capillary electrophoresis. Two proteins, phycoerythrin and phycocyanin, were used as test substances in all these methodological studies. Aqueous two-phase partitioning as a separation method was introduced in 1956 by the author. In this work, chloroplast particles were used, and the method was applied for the separation and purification of intact chloroplasts, inside-out thylakoid vesicles and plasma membranes. My research was carried out in cooperation with G. Blomquist, G. Johansson, C. Larsson, B. Andersson and H.-E. Akerlund during a 20-year period, 1960-1980. 相似文献
37.
Schiött A Johansson AC Widegren B Sjögren HO Lindvall M 《Cancer immunology, immunotherapy : CII》2000,48(10):579-587
The cytokine transforming growth factor β-1 (TGFβ1), was transfected into a TGFβ1-negative rat colon carcinoma. The growth
of isografts of TGFβ1-expressing tumors was compared to that of vector control transfectants. The TGFβ1 transfectant grew
significantly more slowly after intrahepatic isografting than did vector control and wild-type tumors. The TGFβ1-transfected
tumor tissue had significantly greater infiltration of both CD4+ and CD8+ T lymphocytes than did the vector control tumor. The tumor-infiltrating leukocytes (TIL) from TGFβ1-transfected tumor secreted
significantly more of the cytokines interleukin-10 (IL-10) and tumor necrosis factor α (TNFα) than did TIL from the vector
control tumor. The TGFβ1 transfectant also demonstrated a significantly slower outgrowth in immunodeficient SCID mice, supporting
a non-T-lymphocyte-dependent mechanism for the tumor retardation. In SCID mice, the TGFβ1-transfected tumor demonstrated significantly
greater infiltration of both granulocytes and macrophages than did the vector control transfectant. We also demonstrated a
direct inhibitory effect of rat TNFα on tumor proliferation in vitro. These results suggest that TGFβ1 induces a local secretion
of immunomodulating cytokines and that this may influence monocytes, lymphocytes and granulocytes to retard tumor outgrowth.
Received: 7 July 1999 / Accepted: 12 August 1999 相似文献
38.
39.
Åke Lindström Juliana Dänhardt Martin Green Raymond H. G. Klaassen Peter Olsson 《Journal of avian biology》2010,41(2):154-162
Today's intensive farming practices are known to have affected farmland biodiversity negatively in many different ways. As far as birds are concerned, they are known to have suffered during both summer and winter. Relatively little is known about the effects on birds during migration. We studied the stopover ecology of the Eurasian golden plover Pluvialis apricaria, a species listed in EU Birds Directive, in intensively farmed arable land in southernmost Sweden in the autumns of 2003–2007. We used key ecological variables (length of stay, fat deposition and moult) as fitness proxies to evaluate how the birds manage in this habitat. Eurasian golden plovers were present in large numbers mainly on arable fields from early August to November and radio‐tagged birds were found to stay in the area for up to three months. Adult birds carried out a substantial part of their flight feather moult during their stay. Body mass increased only somewhat during moult, but from the last stages of moult and onwards fuel loads corresponding to 24% above lean body mass (LBM) were accumulated at a rate of 0.5% of LBM per day, before the birds departed. Juveniles arrived later, from mid Sep., and had a similar pattern of fuel deposition. The fact that the birds choose to stay for long periods, moult in the area, and manage to store substantial fuel loads strongly suggests that Eurasian golden plovers do well in this intensively farmed arable land. 相似文献
40.
Edward G. Robins Yongjun Zhao Imtiaz Khan Anthony Wilson Sajinder K. Luthra Erik Årstad 《Bioorganic & medicinal chemistry letters》2010,20(5):1749-1751
Two S-[18F]fluoroalkylated diarylguanidines were synthesized and evaluated in vitro as potential tracers for imaging of N-methyl-d-aspartate receptors (NMDARs) with positron emission tomography (PET). [18F]1 and [18F]10 were synthesized by [18F]fluoroethylation and [18F]fluoromethylation of the thiol precursor 6, respectively. [18F]1 is a promising candidate NMDAR PET tracer, with low nanomolar affinity for the NMDA PCP-site, high selectivity and moderate lipophilicity. 相似文献