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991.
992.
The placental transport and palatal localization of l-thyroxine-125I was studied in Sprague-Dawley rat embryos ages 13 and 14 days in vivo and 14–16 days in vitro. Amniotic fluid, placenta and (by late day 14) embryonic/palatal and liver areas were assayed by scintillation counting and protein analysis. Radioactivity was found in amniotic fluid as early as 13 days in vivo. A small but consistent amount of radioactivity above control levels was found in the embryonic palatal and liver areas. Autoradiographs of thin-layer chromatographs showed that most of the radioactive label was at the thyroxine area in both 13- and 14-day in vivo and 15-day in vitro amniotic fluid pools. A small amount of radioactivity was present in the diiodothyronine area in both. Some activity was also present in the triiodothyronine area in the 13- and 14-day samples. No labelled inorganic iodide was detectable. The thyroid gland in rat does not begin to function until 17 days in utero. Accordingly, the labelled thyroxine was exogenous. The presence of labelling in the embryonic palate suggests a possible involvement of this hormone in palatal embryogenesis. 相似文献
993.
994.
Lois B. Epstein Mary E. Rose Nancy H. McManus 《Biochemical and biophysical research communications》1982,104(1):341-346
A comparison of the amino acid sequence of one human recombinant IFN-α (IFLrA) with either human β-endorphin or ACTH reveals only a minimal and insignificant degree of homology. Also, synthetic ACTH, β-endorphin and β-endorphin-(1–15) have no antiviral protective effects on human fibroblasts and cannot inhibit the neutralization of the antiviral effects of natural IFN-α by an antiserum directed against the interferon. Anti ACTH and Anti β-endorphin do not neutralize the antiviral effects of IFLrA, and radioimmunoassays of partially purified natural IFN-α and pure IFLrA do not reveal any evidence of α-MSH or β-endorphin-like material in the interferons. These results demonstrate an absence of functional and structural homology of natural and recombinant IFN-α with ACTH and β-endorphin. 相似文献
995.
Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family 总被引:14,自引:0,他引:14
A novel class II beta chain gene is described. This gene, tentatively called DO beta, displays considerably less polymorphism than beta genes of the DP, DQ, and DR loci. The nucleotide sequence of the DO beta gene is strikingly similar to that of the previously identified murine A beta 2 gene. The DO beta gene displays the same exon/intron organization as other beta genes although the fifth exon and the translated portion of the sixth exon are longer than in other genes. A striking feature of the amino acid sequence deduced from the DO beta gene sequence is the pronounced hydrophobicity of the NH2-terminal region. This feature distinguishes the putative DO beta chain from other class II beta chains and raises the possibility that DO beta chains may interact with an alpha chain that is structurally different from those of the DP, DQ, and DR loci. It further suggests that the putative DO molecule may have a function different from those of other class II antigens. 相似文献
996.
997.
Chemical and biochemical crosslinking of membrane components 总被引:6,自引:0,他引:6
B J Gaffney 《Biochimica et biophysica acta》1985,822(3-4):289-317
998.
L Levine M N Sawka B E Joyce B S Cadarette K B Pandolf 《European journal of applied physiology and occupational physiology》1984,53(1):12-16
Comparisons of physiological responses to 0, 0.5, 1, and 2 mg atropine (IM) were made in seven males (X +/- SD: age, 24 +/- 3 years; ht, 174 +/- 12 cm; wt, 76 +/- 3 kg) while they exercised (approximately 390 W) in a hot-dry (40 degrees C, 20% rh) environment. Responses to 4 mg, as well as repeatability of responses to 2 mg, were studied in two and six of these subjects, respectively. On 8 test days an intramuscular injection of atropine or saline control was administered 20 min before subjects walked on a treadmill for two 50-min bouts. Heart rate (HR) during exercise did not change in the control trial but by min 50 increased during all atropine trials (P less than 0.01). Rectal temperature (Tre) increased (P less than 0.01) in all trials by min 50 and continued increasing (P less than 0.01) in the 2-mg trial during the second exercise bout. For the two subjects tested with all dosages (0.5 - 4 mg atropine), the change in HR and Tre between the atropine and control trials at 50 min of exercise was regressed against the various atropine dosages. The relationship (r = 0.92) for HR was curvilinear while the relationship (r = 0.99) for Tre was linear. Mean weighted skin temperature (Tsk) was relatively constant during exercise and was warmer (P less than 0.05) with increasing atropine dosage. In a repeat 2 mg trial, HR was 6 bt . min-1 lower (P less than 0.05) on the second exposure but Tre was the same (P greater than 0.05) on both days. For subjects walking in the heat, three new observations were: 1) 0.5 mg of atropine resulted in increased HR and Tsk compared to control values; 2) HR was elevated but the magnitude of change decreased with increasing dosage, while the elevation in Tre was consistent with increasing dosage; and 3) rectal temperatures (in trials with and without atropine) were unaffected by previous days of atropine administration. 相似文献
999.
N Bonaventure B Jardon 《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1992,315(6):241-246
The systemic administration of atropine, a muscarinic cholinergic antagonist, was found to suppress the Nasal-Temporal (N-T) component of the frog monocular optokinetic nystagmus (OKN), which had appeared following a prior injection of bicuculline and which does not exist in the normal animal. On the contrary, the administration of a nicotinic cholinergic antagonist (D-TC, alpha-BGT, Hexamethonium) following that of bicuculline has prolonged the duration of the induced N-T component. Thus, ACh was shown to attenuate or to reinforce the GABAergic inhibition of the N-T component through muscarinic receptors or nicotinic receptors respectively. These data point to the existence of strong interactions between these two neurotransmission systems involved in frog monocular OKN. 相似文献
1000.
Daniel M. Wetzel Ursula L. Haerter Darcy B. Kelley 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1985,157(6):749-761
Vocalizations of South African clawed frogs are produced by contractions of laryngeal muscles innervated by motor neurons of the caudal medulla (within cranial nerve nucleus IX-X). We have traced afferents to laryngeal motor neurons in male and female frogs using retrograde axonal transport of horseradish peroxidase conjugated to wheat germ agglutinin (HRP-WGA). After iontophoretic injection of HRP-WGA into n. IX-X, retrogradely labelled neurons were seen in the contralateral n. IX-X, in rhombencephalic reticular nuclei, and in the pre-trigeminal nucleus of the dorsal tegmental area (DTAM) of both males and females. 相似文献