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Ul Hassan Mahmood Rasool Tassaduq Iqbal Chandni Arshad Adnan Abrar Muhammad Abrar Muhammad Mohsin Habib-ur-Rahman Muhammad Noor Mehmood Ali Sher Alam Fahad Shah 《Journal of Plant Growth Regulation》2022,41(7):2596-2613
Journal of Plant Growth Regulation - The general circulation models estimated an average increase in global surface temperature about 4 °C (2.9 to 5.5 °C). Escalating... 相似文献
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Rabail H. Toor Shabana Malik Haleema Qamar Faiza Batool Maira Tariq Zainab Nasir Raazia Tassaduq Jane B. Lian Janet L. Stein Gary S. Stein Abdul R. Shakoori 《Journal of cellular physiology》2019,234(12):23082-23096
In continuation of the investigation of osteogenic potential of solvent fractions of ethanolic extract of Cissus quadrangularis (CQ), an ancient medicinal plant, most notably known for its bone-healing properties, to isolate and identify antiosteoporotic compounds. In the current study, we report the effect of hexane fraction (CQ-H) and dichloromethane fraction (CQ-D) of CQ on the differentiation and mineralization of mouse preosteoblast cell line MC3T3-E1 (subclone 4). Growth, viability, and proliferation assays revealed that low concentrations (0.1, 1, and 100 ng/ml) of both solvent fractions were nontoxic, whereas higher concentrations were toxic to the cells. Differentiation and mineralization of MC3T3-E1 with nontoxic concentrations of CQ-D and CQ-H revealed that CQ-D delayed the mineralization of MC3T3-E1 cells. However, early and enhanced mineralization was observed in cultures treated with nontoxic concentrations of CQ-H, as indicated by Von Kossa staining and expression profile of osteoblast marker genes such as osterix, Runx2, alkaline phosphatase (ALP), collagen (Col1a1), integrin-related bone sialoprotein (IBSP), osteopontin (OPN), and osteocalcin (OCN). These findings suggest CQ-H as the most efficacious solvent fraction for further investigation to isolate and identify the active compounds in CQ-H. 相似文献
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