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1.
Eduardo Molina Josep Maria Espelta Joan Pino Guillem Bagaria Dolors Armenteras 《Biotropica》2018,50(5):740-749
The spatial heterogeneity of resource availability is a major driver of biodiversity patterns. Some environmental conditions and resources are characterized by large‐scale patterns of variation within the landscape. Clumped local discontinuities or discrete elements also increase spatial heterogeneity, promoting local ‘biodiversity hot spots’ by modifying habitat characteristics and promoting plant–animal interactions. Clay licks are faunal attractors owing to their role in the nutritional ecology of the user species; nevertheless, the effect of their presence on the surrounding vegetation has been poorly quantified. Here, we use data from 100 × 10 m transects and evaluate the effects of the presence of clay licks on forest diversity and structure at local and landscape scales. In clay lick areas, there was a higher abundance of certain species, which helps to homogenize species composition between localities counteracting the natural distance‐decay of compositional similarity between transects without clay lick influence (controls). Compared to control sites, clay lick′s forests had higher palm densities, shorter but more variable individuals in the canopy and understory, a thinner canopy layer, and denser herbaceous and ground level covers. These differences were found along the whole length of transects in both sampled areas types. These results reveal that the presence of discrete elements (i.e., clay licks) may help to explain the compositional and structural heterogeneity of Amazonian forests influencing ecological processes such as seed dispersal and trampling. These considerations may be relevant for other biomes where clay licks are present and give weight to their inclusion in conservation initiatives in tropical forests. 相似文献
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Federica Battistini Pablo D. Dans Montserrat Terrazas Chiara L. Castellazzi Guillem Portella Mireia Labrador Núria Villegas Isabelle Brun-Heath Carlos Gonzlez Modesto Orozco 《PLoS computational biology》2021,17(11)
We present a comprehensive, experimental and theoretical study of the impact of 5-hydroxymethylation of DNA cytosine. Using molecular dynamics, biophysical experiments and NMR spectroscopy, we found that Ten-Eleven translocation (TET) dioxygenases generate an epigenetic variant with structural and physical properties similar to those of 5-methylcytosine. Experiments and simulations demonstrate that 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) generally lead to stiffer DNA than normal cytosine, with poorer circularization efficiencies and lower ability to form nucleosomes. In particular, we can rule out the hypothesis that hydroxymethylation reverts to unmodified cytosine physical properties, as hmC is even more rigid than mC. Thus, we do not expect dramatic changes in the chromatin structure induced by differences in physical properties between d(mCpG) and d(hmCpG). Conversely, our simulations suggest that methylated-DNA binding domains (MBDs), associated with repression activities, are sensitive to the substitution d(mCpG) ➔ d(hmCpG), while MBD3 which has a dual activation/repression activity is not sensitive to the d(mCpG) d(hmCpG) change. Overall, while gene activity changes due to cytosine methylation are the result of the combination of stiffness-related chromatin reorganization and MBD binding, those associated to 5-hydroxylation of methylcytosine could be explained by a change in the balance of repression/activation pathways related to differential MBD binding. 相似文献
3.
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises 总被引:3,自引:0,他引:3
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease. Pericytes are implicated in the development of diabetic retinopathy and tissue fibrosis, and they are potential stromal targets for cancer therapy. Some pericytes are probably mesenchymal stem or progenitor cells, which give rise to adipocytes, cartilage, bone, and muscle. However, there is still confusion about the identity, ontogeny, and progeny of pericytes. Here, we review the history of these investigations, indicate emerging concepts, and point out problems and promise in the field of pericyte biology. 相似文献
4.
Guillem Portella Tanja Polupanow Florian Zocher Danila?A. Boytsov Peter Pohl Ulf Diederichsen Bert?L. de?Groot 《Biophysical journal》2012,103(8):1698-1705
Water permeability through single-file channels is affected by intrinsic factors such as their size and polarity and by external determinants like their lipid environment in the membrane. Previous computational studies revealed that the obstruction of the channel by lipid headgroups can be long-lived, in the range of nanoseconds, and that pore-length-matching membrane mimetics could speed up water permeability. To test the hypothesis of lipid-channel interactions modulating channel permeability, we designed different gramicidin A derivatives with attached acyl chains. By combining extensive molecular-dynamics simulations and single-channel water permeation measurements, we show that by tuning lipid-channel interactions, these modifications reduce the presence of lipid headgroups in the pore, which leads to a clear and selective increase in their water permeability. 相似文献
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6.
Guillem A Alegría A Barberá R Farré R Lagarda MJ Clemente G 《Biological trace element research》2000,75(1-3):11-19
Seven zinc salts—acetate, chloride, lactate, sulfate, citrate, gluconate, and oxide—were added to milk—and soy-based infant
formulas to estimate possible differences in zinc availability depending on the type of salt used. For this purpose, an in
vitro method that estimates the dialyzability of the element (i.e., the fraction available for absorption) was applied. Zinc
dialyzability is always higher in milk-based products than in soy products, even when the total zinc contents are higher in
the latter.
The salts can be classified according to the zinc dialyzability in the two types of formulas as follows: oxide>gluconate=chloride=lactate>citrate=acetate>sulfate.
Therefore, according to the dialysis percentage, oxide and gluconate are the compounds of choice for zinc supplementation
of infant formulas. 相似文献
7.
Guillem Molina-Vacas Rafael Muñoz-Mas Francisco Martínez-Capel José Domingo Rodriguez-Teijeiro Guillaume Le Fohlic 《African Journal of Ecology》2020,58(1):23-33
African forest elephants (Loxodonta cyclotis Matschie, 1900) are ecological engineers that play a fundamental role in vegetation dynamics. The species is of immediate conservation concern, yet it is relatively understudied. To narrow this knowledge gap, we studied the drivers of daily movement patterns (linear displacements) of forest elephants—characterised by a set of geographical, meteorological and anthropogenic variables—in the Odzala-Kokoua National Park, Republic of Congo. Explicitly, we used conditional random forest to model and disentangle the main environmental factors governing the displacements of six forest elephants, fitted with GPS collars and tracked over 16 months. Results indicated that females moved further distances than males, while the presence of roads or human settlements disrupted elephant behaviour resulting in faster displacements. Forest elephants moved faster along watercourses and through forest with understory dominated by Marantaceae forests and bais, but moved slower in savannahs. Finally, flood-prone areas—described by elevation and accumulated precipitation—and higher temperatures prevented longer displacements. We expect these results to improve the knowledge on the species movements through different habitats, which would benefit its conservation management. 相似文献
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9.
Jorma J. de Ronde Guillem Rigaill Sven Rottenberg Sjoerd Rodenhuis Lodewyk F. A. Wessels 《Nucleic acids research》2013,41(21):e200
Traditional methods that aim to identify biomarkers that distinguish between two groups, like Significance Analysis of Microarrays or the t-test, perform optimally when such biomarkers show homogeneous behavior within each group and differential behavior between the groups. However, in many applications, this is not the case. Instead, a subgroup of samples in one group shows differential behavior with respect to all other samples. To successfully detect markers showing such imbalanced patterns of differential signal, a different approach is required. We propose a novel method, specifically designed for the Detection of Imbalanced Differential Signal (DIDS). We use an artificial dataset and a human breast cancer dataset to measure its performance and compare it with three traditional methods and four approaches that take imbalanced signal into account. Supported by extensive experimental results, we show that DIDS outperforms all other approaches in terms of power and positive predictive value. In a mouse breast cancer dataset, DIDS is the only approach that detects a functionally validated marker of chemotherapy resistance. DIDS can be applied to any continuous value data, including gene expression data, and in any context where imbalanced differential signal is manifested. 相似文献
10.
Guillem Chust J. Icarus Allen Laurent Bopp Corinna Schrum Jason Holt Kostas Tsiaras Marco Zavatarelli Marina Chifflet Heather Cannaby Isabelle Dadou Ute Daewel Sarah L. Wakelin Eric Machu Dhanya Pushpadas Momme Butenschon Yuri Artioli George Petihakis Chris Smith Veronique Garçon Katerina Goubanova Briac Le Vu Bettina A. Fach Baris Salihoglu Emanuela Clementi Xabier Irigoien 《Global Change Biology》2014,20(7):2124-2139
Ocean warming can modify the ecophysiology and distribution of marine organisms, and relationships between species, with nonlinear interactions between ecosystem components potentially resulting in trophic amplification. Trophic amplification (or attenuation) describe the propagation of a hydroclimatic signal up the food web, causing magnification (or depression) of biomass values along one or more trophic pathways. We have employed 3‐D coupled physical‐biogeochemical models to explore ecosystem responses to climate change with a focus on trophic amplification. The response of phytoplankton and zooplankton to global climate‐change projections, carried out with the IPSL Earth System Model by the end of the century, is analysed at global and regional basis, including European seas (NE Atlantic, Barents Sea, Baltic Sea, Black Sea, Bay of Biscay, Adriatic Sea, Aegean Sea) and the Eastern Boundary Upwelling System (Benguela). Results indicate that globally and in Atlantic Margin and North Sea, increased ocean stratification causes primary production and zooplankton biomass to decrease in response to a warming climate, whilst in the Barents, Baltic and Black Seas, primary production and zooplankton biomass increase. Projected warming characterized by an increase in sea surface temperature of 2.29 ± 0.05 °C leads to a reduction in zooplankton and phytoplankton biomasses of 11% and 6%, respectively. This suggests negative amplification of climate driven modifications of trophic level biomass through bottom‐up control, leading to a reduced capacity of oceans to regulate climate through the biological carbon pump. Simulations suggest negative amplification is the dominant response across 47% of the ocean surface and prevails in the tropical oceans; whilst positive trophic amplification prevails in the Arctic and Antarctic oceans. Trophic attenuation is projected in temperate seas. Uncertainties in ocean plankton projections, associated to the use of single global and regional models, imply the need for caution when extending these considerations into higher trophic levels. 相似文献