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1.
Zakhar O. Shenkarev Mikhail A. Shulepko Maxim L. Bychkov Dmitrii S. Kulbatskii Olga V. Shlepova Nathalia A. Vasilyeva Alexander A. Andreev-Andrievskiy Anfisa S. Popova Evgeniya A. Lagereva Eugene V. Loktyushov Sergey G. Koshelev Morten S. Thomsen Dmitry A. Dolgikh Sergey A. Kozlov Pavel M. Balaban Mikhail P. Kirpichnikov Ekaterina N. Lyukmanova 《Journal of neurochemistry》2020,155(1):45-61
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Mazanko Maria S. Makarenko Maksim S. Chistyakov Vladimir A. Usatov Alexander V. Prazdnova Evgeniya V. Bren Anzhelika B. Gorlov Ivan F. Komarova Zoya B. Weeks Richard Chikindas Michael L. 《Probiotics and antimicrobial proteins》2019,11(4):1324-1329
Probiotics and Antimicrobial Proteins - A promising approach for slowing down the rate of reproductive aging is the use of probiotic bacteria as a feed additive. In the current study was... 相似文献
3.
Heier L Storvik GO Davis SA Viljugrein H Ageyev VS Klassovskaya E Stenseth NC 《Proceedings. Biological sciences / The Royal Society》2011,278(1720):2915-2923
Predicting the dynamics of zoonoses in wildlife is important not only for prevention of transmission to humans, but also for improving the general understanding of epidemiological processes. A large dataset on sylvatic plague in the Pre-Balkhash area of Kazakhstan (collected for surveillance purposes) provides a rare opportunity for detailed statistical modelling of an infectious disease. Previous work using these data has revealed a host abundance threshold for epizootics, and climatic influences on plague prevalence. Here, we present a model describing the local space-time dynamics of the disease at a spatial scale of 20 × 20 km(2) and a biannual temporal scale, distinguishing between invasion and persistence events. We used a Bayesian imputation method to account for uncertainties resulting from poor data in explanatory variables and response variables. Spatial autocorrelation in the data was accounted for in imputations and analyses through random effects. The results show (i) a clear effect of spatial transmission, (ii) a high probability of persistence compared with invasion, and (iii) a stronger influence of rodent abundance on invasion than on persistence. In particular, there was a substantial probability of persistence also at low host abundance. 相似文献
4.
Olga E. Philippova Evgeniya V. KorchaginaEvgeny V. Volkov Valery A. SmirnovAlexei R. Khokhlov Marguerite Rinaudo 《Carbohydrate polymers》2012,87(1):687-694
By dynamic light scattering in combination with fluorescence spectroscopy and TEM it was shown that aggregation in aqueous solutions is inherent not only to chitosan, but also to two other water-soluble derivatives of chitin: O-carboxymethylchitin and di-N,N-carboxymethylchitosan. Aggregation is observed even for the samples without N-acetyl-d-glucosamine units, which remain upon incomplete chemical modification of chitin, indicating that specific interactions between residual chitin repeat units cannot be the main reason for the aggregation. At the same time, 7 M urea weakens the aggregation, thus testifying that hydrogen bonding and/or hydrophobic interactions are partially responsible for this phenomenon. The incomplete disruption of aggregates in 7 M urea may arise from crystallization of junction zones between different macromolecules, which makes some hydrogen bonds inaccessible for urea or too stable for breaking by this agent. 相似文献
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Mazanko Maria S. Gorlov Ivan F. Prazdnova Evgeniya V. Makarenko Maxim S. Usatov Alexander V. Bren Anzhelika B. Chistyakov Vladimir A. Tutelyan Alexey V. Komarova Zoya B. Mosolova Natalia I. Pilipenko Denis N. Krotova Olga E. Struk Aleksandr N. Lin Angela Chikindas Michael L. 《Probiotics and antimicrobial proteins》2018,10(2):367-373
Probiotics and Antimicrobial Proteins - The study aims at elucidating the effect of bacilli probiotic preparations on the physiology of laying hens and roosters. Probiotic formulations were... 相似文献
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Collingwood TS Smirnova EV Bogush M Carpino N Annan RS Tsygankov AY 《The Journal of biological chemistry》2007,282(42):30920-30928
The lymphoid protein T-cell ubiquitin ligand (TULA)/suppressor of T-cell receptor signaling (Sts)-2 is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases. The results presented in this report indicate that TULA facilitates T-cell apoptosis independent of either T-cell receptor/CD3-mediated signaling or caspase activity. Mass spectrometry-based analysis of protein-protein interactions of TULA demonstrates that TULA binds to the apoptosis-inducing protein AIF, which has previously been shown to function as a key factor of caspase-independent apoptosis. Using RNA interference, we demonstrate that AIF is essential for the apoptotic effect of TULA. Analysis of the subcellular localization of TULA and AIF together with the functional analysis of TULA mutants is consistent with the idea that TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors, which remain to be identified. Overall, our results shed new light on the biological functions of TULA, a recently discovered protein, describing its role as one of very few known functional interactors of AIF. 相似文献
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Stephka G. Chankova Nadezhda P. Yurina Evgeniya G. Dimova Olga V. Ermohina Yulia P. Oleskina Maria T. Dimitrova Peter E. Bryant 《Journal of thermal biology》2009,34(7):332-336
We aimed to clarify if heat pretreatment could protect Chlamydomonas reinhardtii cells from gamma rays DNA damaging action. It was studied whether: (1) heat pretreatment could accelerate DNA DSB rejoining; (2) chloroplast chaperones (HSP70B, HSP90C) could be involved in protection from radiation-induced DNA DSB.It was obtained that heat pretreatment (37–42 °C) induced minor DNA DSB levels which might be insufficient as signals for DNA DSB repair induction. No correlation between chaperones overproduction and DNA DSB rejoining was shown. These are probably the first data that HSP70B and HSP90C do not protect DNA against radiation-induced damage in a plant model system. 相似文献
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Mariya V. Kovaleva Evgeniya I. Sukhanova Tatyana A. Trendeleva Marina V. Zyl’kova Ludmila A. Ural’skaya Kristina M. Popova Nils-Erik L. Saris Renata A. Zvyagilskaya 《Journal of bioenergetics and biomembranes》2009,41(3):239-249
In this study we used tightly-coupled mitochondria from Yarrowia lipolytica and Dipodascus (Endomyces) magnusii yeasts, possessing a respiratory chain with the usual three points of energy conservation. High-amplitude swelling and collapse
of the membrane potential were used as parameters for demonstrating induction of the mitochondrial permeability transition
due to opening of a pore (mPTP). Mitochondria from Y. lipolytica, lacking a natural mitochondrial Ca2+ uptake pathway, and from D. magnusii, harboring a high-capacitive, regulated mitochondrial Ca2+ transport system (Bazhenova et al. J Biol Chem 273:4372–4377, 1998a; Bazhenova et al. Biochim Biophys Acta 1371:96–100, 1998b; Deryabina and Zvyagilskaya Biochemistry (Moscow) 65:1352–1356, 2000; Deryabina et al. J Biol Chem 276:47801–47806, 2001) were very resistant to Ca2+ overload. However, exposure of yeast mitochondria to 50–100 μM Ca2+ in the presence of the Ca2+ ionophore ETH129 induced collapse of the membrane potential, possibly due to activation of the fatty acid-dependent Ca2+/nH+-antiporter, with no classical mPTP induction. The absence of response in yeast mitochondria was not simply due to structural
limitations, since large-amplitude swelling occurred in the presence of alamethicin, a hydrophobic, helical peptide, forming
voltage-sensitive ion channels in lipid membranes. Ca2+- ETH129-induced activation of the Ca2+/H+-antiport system was inhibited and prevented by bovine serum albumin, and partially by inorganic phosphate and ATP. We subjected
yeast mitochondria to other conditions known to induce the permeability transition in animal mitochondria, i.e., Ca2+ overload (in the presence of ETH129) combined with palmitic acid (Mironova et al. J Bioenerg Biomembr 33:319–331, 2001; Sultan and Sokolove Arch Biochem Biophys 386:37–51, 2001), SH-reagents, carboxyatractyloside (an inhibitor of the ADP/ATP translocator), depletion of intramitochondrial adenine nucleotide
pools, deenergization of mitochondria, and shifting to acidic pH values in the presence of high phosphate concentrations.
None of the above-mentioned substances or conditions induced a mPTP-like pore. It is thus evident that the permeability transition
in yeast mitochondria is not coupled with Ca2+ uptake and is differently regulated compared to the mPTP of animal mitochondria. 相似文献
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