排序方式: 共有35条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
Progeny From Irradiated Colorectal Cancer Cells Acquire an EMT‐Like Phenotype and Activate Wnt/β‐Catenin Pathway 下载免费PDF全文
Lilian Gonçalves dos Reis Bastos Priscila Guimarães de Marcondes Julio Cesar Madureira de‐Freitas‐Junior Fernanda Leve André Luiz Mencalha Waldemir Fernandes de Souza Wallace Martins de Araujo Marcelo Neves Tanaka Eliana Saul Furquim Werneck Abdelhay José Andrés Morgado‐Díaz 《Journal of cellular biochemistry》2014,115(12):2175-2187
7.
Luize Otero Daiane Correa de Souza Rita de Cássia Tavares Bernadete Evangelho Gomes Telma Fran?a Padilha Luiz Fernando Bouzas Teresa de Souza Fernandez Eliana Abdelhay 《Genetics and molecular biology》2012,35(4):734-736
Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient’s bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells. 相似文献
8.
9.
10.
de-Freitas-Junior JC Bastos LG Freire-Neto CA Rocher BD Abdelhay ES Morgado-Díaz JA 《Journal of cellular biochemistry》2012,113(9):2957-2966
During malignant transformation, changes in the expression profile of glycans may be involved in a variety of events, including the loss of cell-cell and cell-matrix adhesion, migration, invasion, and evasion of apoptosis. Therefore, modulation of glycan expression with drugs has promising therapeutic potential for various cancer types. In this study, we investigated the in vitro anticancer activity of the N-glycan biosynthesis inhibitors (swainsonine and tunicamycin) in cells derived from colorectal cancer (CRC). We also examined whether these inhibitors are able to induce radiosensitization and toxicity when used in combination with cisplatin or irinotecan, two current anticancer drugs. Our results show that treatment with tunicamycin inhibits cellular mechanisms related to the malignant phenotype, such as anchorage-dependent and anchorage-independent colony formation, migration and invasion, in undifferentiated HCT-116 colon cancer cells, whereas swainsonine only inhibits cell migration. We also observed that tunicamycin, but not swainsonine, caused radiosensitivity in HCT-116 cells. Moreover, the combination of swainsonine with cisplatin or irinotecan enhanced their toxicity in HCT-116 cells, while the combination of tunicamycin with these drugs had no effect. Given these results, we suggest that the modulation of N-glycan biosynthesis appears to be a potential therapeutic tool for CRC treatment because inhibition of this process induced anticancer activity in vitro. Additionally, the inhibition of the N-glycan biosynthesis in combination with chemotherapic drugs is a promising therapeutic strategy for enhancing radiation therapy. 相似文献