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Bryndan P. Durham Jana Grote Kerry A. Whittaker Sara J. Bender Haiwei Luo Sharon L. Grim Julia M. Brown John R. Casey Antony Dron Lennin Florez-Leiva Andreas Krupke Catherine M. Luria Aric H. Mine Olivia D. Nigro Santhiska Pather Agathe Talarmin Emma K. Wear Thomas S. Weber Jesse M. Wilson Matthew J. Church Edward F. DeLong David M. Karl Grieg F. Steward John M. Eppley Nikos C. Kyrpides Stephan Schuster Michael S. Rappé 《Standards in genomic sciences》2014,9(3):632-645
Strain HIMB11 is a planktonic marine bacterium isolated from coastal seawater in Kaneohe Bay, Oahu, Hawaii belonging to the ubiquitous and versatile Roseobacter clade of the alphaproteobacterial family Rhodobacteraceae. Here we describe the preliminary characteristics of strain HIMB11, including annotation of the draft genome sequence and comparative genomic analysis with other members of the Roseobacter lineage. The 3,098,747 bp draft genome is arranged in 34 contigs and contains 3,183 protein-coding genes and 54 RNA genes. Phylogenomic and 16S rRNA gene analyses indicate that HIMB11 represents a unique sublineage within the Roseobacter clade. Comparison with other publicly available genome sequences from members of the Roseobacter lineage reveals that strain HIMB11 has the genomic potential to utilize a wide variety of energy sources (e.g. organic matter, reduced inorganic sulfur, light, carbon monoxide), while possessing a reduced number of substrate transporters. 相似文献
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The influence of experimental temperature on the permeability of model diffusants across porcine buccal mucosa was investigated
in vitro. The permeability increased significantly as the experimental temperature was increased in increments of approximately 7°C.
It was observed that the apparent permeability and temperature were related by an exponential relationship that conformed
to the Arrhenius equation. Diffusants with higher lipophilicities—buspirone and bupivacaine—had lower activation energies
for diffusion when compared to hydrophilic diffusants—antipyrine and caffeine. The activation energy for diffusion of the
model diffusants decreased linearly with increasing distribution coefficients across porcine buccal mucosa. The results suggested
that the buccal mucosa acts as a stronger barrier to the diffusion of hydrophilic diffusants than the lipophilic ones. The
log-linear relationship between permeability and temperature indicates that temperature should be carefully controlled in
diffusion experiments. These results also point to the possibility of developing heat-generating buccal delivery devices,
especially for hydrophobic diffusants. 相似文献
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Background
Lymphadenopathy is a common clinical presentation of disease in South Africa (SA), particularly in the era of Human Immunodeficiency Virus (HIV) and tuberculosis (TB) co-infection.Methods
Data from 560 lymph node biopsy reports of specimens from patients older than 12 years at Chris Hani Baragwanath Academic Hospital (CHBAH) between 1 January 2010 and 31 December 2012 was extracted from the National Health Laboratory Service (NHLS), division of Anatomical Pathology. Cytology reports of lymph node fine needle aspirates (FNAs) performed prior to lymph node biopsy in 203 patients were also extracted from the NHLS. Consent was not obtained from participants for their records to be used as patient information was anonymized and de-identified prior to analysis.Results
The majority of patients were female (55%) and of the African/black racial group (90%). The median age of patients was 40 years (range12–94). The most common indication for biopsy was an uncertain diagnosis (more than two differential diagnoses entertained), followed by a suspicion for lymphoma, carcinoma and TB. Overall, malignancy constituted the largest biopsy pathology group (39%), with 36% of this group being carcinoma and 27% non-Hodgkin lymphoma. 22% of the total sampled nodes displayed necrotizing granulomatous inflammation (including histopathology and cytology demonstrating definite, and suspicious for mycobacterial infection), 8% comprised HIV reactive nodes; in the remainder no specific pathology was identified (nonspecific reactive lymphoid hyperplasia). Kaposi sarcoma (KS) accounted for 2.5% of lymph node pathology in this sample. Concomitant lymph node pathology was diagnosed in four cases of nodal KS (29% of the subset). The co-existing pathologies were TB and Castleman disease. HIV positive patients constituted 49% of this study sample and the majority (64%) of this subset had CD4 counts less than 350 cells/ul. 27% were HIV negative and in the remaining nodes, the HIV status of patients was unknown. The most common lymph node pathologies in HIV positive patients were Mycobacterial infection (31%), HIV reactive nodes (15%), non-Hodgkin lymphoma (15%) and nonspecific reactive lymphoid hyperplasia (15%). Only 8.7% were of Hodgkin lymphoma. In contrast, the most common lymph node pathologies in HIV negative patients were nonspecific reactive lymphoid hyperplasia (45%), carcinoma (25%) and Mycobacterial infection (11%). In this group, non-Hodgkin lymphoma and Hodgkin lymphoma constituted 9% and 8%, respectively. There were more cases of high-grade non-Hodgkin lymphoma in the HIV positive group compared to the HIV negative group. FNA and lymph node biopsy had statistically significant good agreement with regard to Hodgkin lymphoma (K 0.774, SE 0.07, 95% CI 0.606-0.882, p=0.001), non-Hodgkin lymphoma (K 0.640, SE 0.07, 95% CI 0.472-0.807, p=0.001), carcinoma (K 0.723, SE 0.069, 95% CI 0.528-0.918, p=0.001), and mycobacterial infection (K 0.726, SE 0.07, 95% CI 0.618-0.833, p=0.001).Conclusions
The most common lymph node pathologies in CHBAH are malignancies, nonspecific reactive lymphoid hyperplasia, necrotizing granulomatous inflammation and HIV reactive nodes. The distribution of disease differs in HIV positive patients. Overall, adequate FNA samples of lymph nodes have been found to have good correlation with lymph node biopsy findings in our setting. 相似文献4.
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Thesla Palanee-Phillips Katie Schwartz Elizabeth R. Brown Vaneshree Govender Nyaradzo Mgodi Flavia Matovu Kiweewa Gonasagrie Nair Felix Mhlanga Samantha Siva Linda-Gail Bekker Nitesha Jeenarain Zakir Gaffoor Francis Martinson Bonus Makanani Sarita Naidoo Arendevi Pather Jessica Phillip Marla J. Husnik Ariane van der Straten Lydia Soto-Torres Jared Baeten 《PloS one》2015,10(6)
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Y K Seedat M A Omar M A Seedat A Wesley M Pather 《BMJ (Clinical research ed.)》1981,282(6261):360-361
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