排序方式: 共有6条查询结果,搜索用时 21 毫秒
1
1.
2.
Stimulation of receptor-operated (ROCs) and store-operated (SOCs) Ca2+-permeable cation channels by vasoconstrictors has many important physiological functions in vascular smooth muscle. The present review indicates that ROCs and SOCs with diverse properties in different blood vessels are likely to be explained by composition of different subunits from the canonical transient receptor potential (TRPC) family of cation channel proteins. In addition we illustrate that activation of native TRPC ROCs and SOCs involves different phospholipase-mediated transduction pathways linked to generation of diacylglycerol (DAG). Moreover we describe recent novel data showing that the endogenous phospholipid phosphoinositol 4,5-bisphosphate (PIP2) has profound and contrasting actions on TRPC ROCs and SOCs. Optimal activation of a native TRPC6 ROC by angiotensin II (Ang II) requires both depletion of PIP2 and generation of DAG which leads to stimulation of TRPC6 via a PKC-independent mechanism. The data also indicate that PIP2 has a marked constitutive inhibitory action of TRPC6 and DAG and PIP2 are physiological antagonists on TRPC6 ROCs. In contrast PIP2 stimulates TRPC1 SOCs and has an obligatory role in activation of these channels by store-depletion which requires PKC-dependent phosphorylation of TRPC1 proteins. Finally, we conclude that interactions between PIP2 bound to TRPC proteins at rest, generation of DAG and PKC-dependent phosphorylation of TRPC proteins have a fundamental role in activation mechanisms of ROCs and SOCs in vascular smooth muscle. 相似文献
3.
Patrick Yusuf Lee Alice Raha Oishik Pillai Kavya Gupta Shubham Sethi Sonika Mukeshimana Felicite Gerard Lothaire Moghal Mohammad U. Saleh Sohag N. Smith Susan F. Morrell Mary J. Moss James 《Sleep and biological rhythms》2017,15(3):217-225
Sleep and Biological Rhythms - Sleep deprivation is common among university students, and has been associated with poor academic performance and physical dysfunction. However, current literature... 相似文献
4.
Md. Abir Ul Islam Juthy Abedin Nupur Charles T. Hunter Abdullah Al Mamun Sohag Ashaduzzaman Sagar Md. Sazzad Hossain Mona F. A. Dawood Arafat Abdel Hamed Abdel Latef Marián Brestič Md. Tahjib-UI-Arif 《Phyton》2022,91(8):1557-1583
Moringa leaf extract (MLE) has been shown to promote beneficial outcomes in animals and plants. It is rich in amino acids, antioxidants, phytohormones, minerals, and many other bioactive compounds with nutritional and growth-promoting potential. Recent reports indicated that MLE improved abiotic stress tolerance in plants. Our understanding of the mechanisms underlying MLE-mediated abiotic stress tolerance remains limited. This review summarizes the existing literature on the role of MLE in promoting plant abiotic stress acclimation processes. MLE is applied to plants in a variety of ways, including foliar spray, rooting media, and seed priming. Exogenous application of MLE promoted crop plant growth, photosynthesis, and yield under both nonstress and abiotic stress conditions. MLE treatment reduced the severity of osmotic and oxidative stress in plants by regulating osmolyte accumulation, antioxidant synthesis, and secondary metabolites. MLE also improves mineral homeostasis in the presence of abiotic stress. Overall, this review describes the potential mechanisms underpinning MLE-mediated stress tolerance. 相似文献
5.
Tahjib-Ul-Arif Md. Siddiqui Md. Nurealam Sohag Abdullah Al Mamun Sakil Md. Arif Rahman Md. Mezanur Polash Mohammed Arif Sadik Mostofa Mohammad Golam Tran Lam-Son Phan 《Journal of Plant Growth Regulation》2018,37(4):1318-1330
Journal of Plant Growth Regulation - Addressing salinity-induced crop losses is a prime concern of modern agriculture to sustain agricultural productivity, thereby contributing to global food... 相似文献
6.
Activation of chloride currents in murine portal vein smooth muscle cells by membrane depolarization involves intracellular calcium release 总被引:3,自引:0,他引:3
The present study describes the first characterization of Ca2+-activated Cl currents (IClCa) in single smooth muscle cells from a murine vascular preparation (portal veins). IClCa was recorded using the perforated patch version of the whole cell voltage-clamp technique and was evoked using membrane depolarization. Generation of IClCa relied on Ca2+ entry through dihydropyridine-sensitive Ca2+ channels because IClCa was abolished by 1 µM nicardipine and enhanced by raising external Ca2+ concentration or by application of BAY K 8644. IClCa was characterized by the sensitivity to Cl channel blockers and the effect of altering the external anion on reversal potential. Activation of IClCa after membrane depolarization was dependent on Ca2+ release from intracellular stores. Thus the amplitude of IClCa was diminished by the SR-ATPase inhibitor cyclopiazonic acid, the inositol 1,4,5-trisphosphate receptor antagonist 2-aminoethoxydiphenyl borate (2-APB), and the ryanodine receptor blocker tetracaine. The degree of inhibition produced by the application of 2-APB and tetracaine together was significantly greater than the effect of each agent applied alone. In current-clamp mode, injection of depolarizing current elicited a biphasic action potential, with the later depolarization being sensitive to niflumic acid (NFA; 10 µM). In isometric tension recordings, NFA inhibited spontaneous contractions. These data support a role for this conductance in portal vein excitability. 相似文献
1