全文获取类型
收费全文 | 640篇 |
免费 | 27篇 |
出版年
2023年 | 2篇 |
2022年 | 7篇 |
2021年 | 13篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 16篇 |
2017年 | 11篇 |
2016年 | 17篇 |
2015年 | 26篇 |
2014年 | 23篇 |
2013年 | 41篇 |
2012年 | 61篇 |
2011年 | 51篇 |
2010年 | 42篇 |
2009年 | 26篇 |
2008年 | 30篇 |
2007年 | 36篇 |
2006年 | 28篇 |
2005年 | 34篇 |
2004年 | 32篇 |
2003年 | 29篇 |
2002年 | 38篇 |
2001年 | 6篇 |
2000年 | 13篇 |
1999年 | 17篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1978年 | 2篇 |
1975年 | 3篇 |
1971年 | 1篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有667条查询结果,搜索用时 15 毫秒
1.
Luke L. M. Heaton Eduardo López Philip K. Maini Mark D. Fricker Nick S. Jones 《Proceedings. Biological sciences / The Royal Society》2010,277(1698):3265-3274
Cord-forming fungi form extensive networks that continuously adapt to maintain an efficient transport system. As osmotically driven water uptake is often distal from the tips, and aqueous fluids are incompressible, we propose that growth induces mass flows across the mycelium, whether or not there are intrahyphal concentration gradients. We imaged the temporal evolution of networks formed by Phanerochaete velutina, and at each stage calculated the unique set of currents that account for the observed changes in cord volume, while minimizing the work required to overcome viscous drag. Predicted speeds were in reasonable agreement with experimental data, and the pressure gradients needed to produce these flows are small. Furthermore, cords that were predicted to carry fast-moving or large currents were significantly more likely to increase in size than cords with slow-moving or small currents. The incompressibility of the fluids within fungi means there is a rapid global response to local fluid movements. Hence velocity of fluid flow is a local signal that conveys quasi-global information about the role of a cord within the mycelium. We suggest that fluid incompressibility and the coupling of growth and mass flow are critical physical features that enable the development of efficient, adaptive biological transport networks. 相似文献
2.
3.
4.
The effect ofl-ascorbic acid on the biosynthesis of aflatoxin inAspergillus parasiticus was studied. Ascorbic acid at lower concentrations did not inhibit the growth of fungus but markedly induced aflatoxin biosynthesis. At a concentration of 1000 ppm of ascorbic acid, 4.8-fold higher levels of aflatoxin were detected. Copper did not enhance the induction of toxin synthesis by ascorbic acid when added to the growth medium. Ascorbic acid at 1000 ppm was also found to induce aflatoxin synthesis in resting mycelia. Chloroform (1% vol/vol) was found to induce aflatoxin synthesis under similar conditions. Ascorbic acid in the presence of ferrous ion can cause lipid peroxidation, which in turn is responsible for the induction of aflatoxin synthesis. During the induction of aflatoxin synthesis by ascorbic acid, the uptake of carbon source (acetate) was not affected. This observation suggests that on ascorbic acid treatment a precursor or an intermediate of aflatoxin biosynthesis is synthesized in vivo and is responsible for the higher levels of toxin without increasing the uptake of acetate. 相似文献
5.
Biological control of eggplant pests in general, and (CPB)Leptinotarsa decemlineata (Say) in particular, is highly problematic.Edovum puttleri Grissell, an exotic egg parasitoid which has been found potentially effective, is being reared to this end. Frozen CPB eggs (?18°C) proved to be accepted and suitable for parasitization byE. puttleri. However, when given a choice between 20 frozen and 20 normal eggs every 2 days, the females exhibited a significant preference for the latter. Parasitization and host predation patterns related to female age are described by 2 opposing fourth-order polynomial functions. Parasitization increased up to day 10, followed by progressive decline. Average life span per female was 31.10±.58, with a recorded maximum of 56 days. High predatory behaviour of older females, which showed a decrease in parasitization, was observed in these experimental conditions. 相似文献
6.
Luke Olsen Jonathan A. Sherratt Philip K. Maini 《Bulletin of mathematical biology》1996,58(4):787-808
The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic
scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic
cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current
medical treatments are thus unreliable.
In this paper, the authors apply an existing deterministic mathematical model for fibroplasia and wound contraction in adult
mammalian dermis (Olsenet al., J. theor. Biol.
177, 113–128, 1995) to investigate key clinical problems concerning these healing disorders. A caricature model is proposed which
retains the fundamental cellular and chemical components of the full model, in order to analyse the spatiotemporal dynamics
of the initiation, progression, cessation and regression of fibro-contractive diseases in relation to normal healing. This
model accounts for fibroblastic cell migration, proliferation and death and growth-factor diffusion, production by cells and
tissue removal/decay.
Explicit results are obtained in terms of the model processes and parameters. The rate of cellular production of the chemical
is shown to be critical to the development of a stable pathological state. Further, cessation and/or regression of the disease
depend on appropriate spatiotemporally varying forms for this production rate, which can be understood in terms of the bistability
of the normal dermal and pathological steady states—a central property of the model, which is evident from stability and bifurcation
analyses.
The work predicts novel, biologically realistic and testable pathogenic and control mechanisms, the understanding of which
will lead toward more effective strategies for clinical therapy of fibro-proliferative disorders. 相似文献
7.
In this paper we use a dynamical systems approach to prove the existence of a unique critical value c
* of the speed c for which the degenerate density-dependent diffusion equation u
ct
= [D(u)u
x
]
x
+ g(u) has: 1. no travelling wave solutions for 0 < c < c
*, 2. a travelling wave solution u(x, t) = (x - c
*
t) of sharp type satisfying (– ) = 1, () = 0 *; '(*–) = – c
*/D'(0), '(*+) = 0 and 3. a continuum of travelling wave solutions of monotone decreasing front type for each c > c
*. These fronts satisfy the boundary conditions (– ) = 1, '(– ) = (+ ) = '(+ ) = 0. We illustrate our analytical results with some numerical solutions. 相似文献
8.
A C Keat R N Maini G C Nkwazi G D Pegrum G L Ridgway J T Scott 《BMJ (Clinical research ed.)》1978,1(6113):605-607
Inflammatory arthritis, tendinitis, and fasciitis after non-specific urethritis ("sexually acquired reactive arthritis" (SARA)) was studied prospectively in 531 men with non-specific urethritis, with particular reference to the frequency of isolation of Chlamydia trachomatis and the presence of HLA-B27. Satisfactory cultures were obtained from the urethral swabs from 384 patients; and HLA typing was performed on 482, of whom 30 (6%) were HLA-B27-positive. Arthritis developed in 16 patients, and five of the 14 (36%) with satisfactory cultures were positive for C trachomatis; 135 of the patients without arthritis were also positive for C trachomatis, an identical proportion. Seven of the 15 patients (40%) with arthritis who were HLA-typed were HLA-B27-positive. Six of the 30 patients with HLA-B27 developed peripheral arthritis in contrast to only nine of the 452 patients lacking the antigen, suggesting a tenfold increase susceptibility. C trachomatis, however, was no more prevalent in cultures from HLA-B27-positive men than from the others. Thus carriage of C trachomatis is unlikely to be influenced by HLA-B27. C trachomatis may be an important pathogen in some cases of SARA but does not appear to be an exclusive trigger factor for this condition. 相似文献
9.
C. Tonini G. Cassani P. Piccardi S. Maini P.L. Castellari E. Pasqualini 《Journal of insect physiology》1982,28(5):443-446
Female-tip washings of the leafroller moth, Pandemis cerasana, were found to contain (E)-11-tetradecenyl acetate, (Z)-11-tetradecenyl acetate, (E)-11-tetradecenol, (Z)-11-tetradecenol and tetradecyl acetate, based on chemical analysis and electroantennogram tests. The relative amounts of these compounds in the gland were ca. 64:21:10:3:2 in the order named. Only (E)-11 and (Z)-11-tetradecenyl acetate were required for attraction of males to trap dispensed in the ratio 3:1, respectively. 相似文献