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1.
Lyubov E. Salnikova Tamara V. Smelaya Viktor V. Moroz Arkady M. Golubev Alexander V. Rubanovich 《Gene》2013
This study was conducted to establish the contribution of genetic host factors in the susceptibility to community acquired pneumonia (CAP) in the Russian population. Patients with CAP (n = 334), volunteers without a previous history of CAP, constantly exposed to infectious agents, control A group (n = 141) and a second control group B consisted of healthy persons (n = 314) were included in the study. All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification CYP1A1 (rs2606345, rs4646903, and rs1048943), GSTM1 (Ins/del), GSTT1 (Ins/del), ABCB1 rs1045642); immune and inflammation response IL-6 (rs1800795), TNF-a (rs1800629), MBL2 (rs7096206), CCR5 (rs333), NOS3 (rs1799983), angiotensin-converting enzyme ACE (rs4340), and occlusive vascular disease/hyperhomocysteinemia MTHFR (rs1801133). Seven polymorphic variants in genes CYP1A1, GSTM1, ABCB1, NOS3, IL6, CCR5 and ACE were associated with CAP. For two genes CYP1A1 and GSTM1 associations remained significant after correction for multiple comparisons. Multiple analysis by the number of all risk genotypes showed a highly significant association with CAP (P = 2.4 × 10− 7, OR = 3.03, 95% CI 1.98–4.64) with the threshold for three risk genotypes. Using the ROC-analysis, the AUC value for multi-locus model was estimated as 68.38. 相似文献
2.
Kal'chenko VA Fedotov IS Igonina EV Rubanovich AV Shevchenko VA 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2000,40(5):607-614
Cytogenetic and genetic effects in populations of Pinus sylvestris L. suffered wiak, average, strong and sublethal radiation damage after the Chernobyl accident in 1986 were studied. The absorbed dozes for trees in these plantings were from 0.1 up to 20 Gy. It was shown that the amount of cells with chromosome aberrations in sprouts of seeds of a crop of 1993, are comparable with effects marked at once after accident in 1986. In 1997 and in 1998 the amount of cells with chromosome aberrations in sprouts of seeds in majority inspected plantings decreased to control values. The effect of adaptation was detected, when seeds of Pinus sylvestris L., gathered in 1997 from inspected trees, were exposed to additional 4 Gy gamma-radiation. 相似文献
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4.
Igonina EV Fedotov IS Korotkevich AIu Rubanovich AV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2012,52(1):90-102
The significant changes of the quantitative signs and the increase in the frequency of morphological abnormalities were found among the offspring of pines (Pinus sylvestris L.) exposed as a result of the Chernobyl accident. We have detected that the typical effects of radiation exposure (stimulation, inhibition, abnormalities of morphogenesis) are transmitted to the offspring of irradiated pine trees. The mechanisms of their occurrence are discussed. 相似文献
5.
Suskov II Kuz'mina NS Suskova VS Agadzhanian AV Rubanovich AV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2008,48(3):278-286
A complex of cytogenetic and of immunogenetic study of the state of the lymphocyte genomes in the liquidators of the ChNPP accident and their unirradiated children has been carried out for the first time. Increased frequencies of the chromosome aberrations, of gene mutations (TCR mutations) and of predictors of apoptosis (cells with CD95+ immunophenotype) have been revealed in both generations. The analysis of correlations between the parameters under study has demonstrated distinctive features characteristic of induction of genomic instability in the organism of unirradiated children as compared to their fathers--liquidators directly exposed to radiation. Individual variability of genome destabilization were observed by all criteria used and manifested themselves in the diverse spectrum of transgenerational mutational effects and in different levels of their expression. The results obtained demonstrate the necessity of integral evaluation of the state of the genome using several genetic criteria to reveal transgenerational genomic instability in children of a special category--the offsprings of irradiated parents. 相似文献
6.
Sal'nikova LE Fomin DK Elisova TV Akaeva EA Kuz'mina NS Lapteva NSh Nilova IN Iofa EL Kostina LN Kuznetsova GI Kulikova TA Panushkina OG Rubanovich AV 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2008,48(3):303-312
The dependence of the level of unstable chromosome aberrations and nononcological diseases on the genotype in 57 liquidators of the ChNPP accident was studied. Candidate genes presumably affecting radiosensitivity were highly polymorphic loci of xenobiotic detoxication genes (glutathione-S-transferases GSTM1, GSTT1, GSTP1) and the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) involved in DNA methylation and synthesis. An increased frequency (0.014 +/- 0.001 per cell) of unstable chromosome aberrations, including radiation-specific dicentrics and centric rings (0.0015 +/- 0.0002 per cell), has been found to be preserved in the group of liquidators examined in 2006-2007. No associations of polymorphism for each of the studied genes with cytogenetic parameters were revealed. Increased frequencies of chromosome aberrations were recorded in homozygous carriers of a deletion at the GSTM1 locus in combination with homozygosity for minor alleles at the MTHFR and GSTP1 loci (p = 0.00002 and p = 0.0233, respectively). The number of homozygous carriers of the minor allele GSTP1 was increased among patients with chronic obstructive pulmonary disease and in liquidators with acute circulation disturbances (p = 0.014 and p = 0.04, respectively). Double homozygotes for GSTM1 and GSTT1 deletions were significantly more frequent among subjects with benign tumors (cysts, polyps, p = 0.015) and with benign thyroid tumors (p = 0.017). This genotype has proved to be protective for patients with severe cardiovascular diseases (acute circulation disturbances, p = 0.027). 相似文献
7.
To evaluate the morphofunctional development of adolescents as dependent on their physiological and chronological ages, physical development, cardiorespiratory system indices, and exercise performance were studied in 12- to 14-year-old boys. The morphofunctional development depended mostly on the sexual maturity. In subjects of the same chronological age, the maturity level substantially influenced the rate of physical development and the condition of the cardiorespiratory system. The maturity stage-dependent increase in absolute morphological and functional indices in 14-year-old adolescents was greater than the age-related increase observed in adolescents with the same stage of sexual maturation.__________Translated from Fiziologiya Cheloveka, Vol. 31, No. 3, 2005, pp. 118–123.Original Russian Text Copyright © 2005 by Girenko, Rubanovich, Aizman. 相似文献
8.
Pomortsev A. A. Rubanovich A. V. Kovaleva O. N. Lyalina E. V. 《Russian Journal of Genetics》2019,55(11):1347-1359
Russian Journal of Genetics - Polymorphism of hordeins encoded by the Hrd A and Hrd B loci was studied using starch gel electrophoresis in 13 barley landrace accessions and in 31 wild barley... 相似文献
9.
Abramov VI Rubanovich AV Shevchenko VA Shevchenko VV Grinikh LI 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2006,46(3):259-267
During 6 years, starting from 1986, the monitoring of the dynamics of the frequency of embryo lethal and of chlorophyll mutations was carried out in arabidopsis populations in areas with different levels of radioactive contamination by the Muller embryo-test in the 30 km of ChNPP. The dose rate of chronic irradiation in the examined areas varied from 0.014 to 17 nA/Kg. Monitoring of the dynamics of the mutation process in natural arabidopsis populations showed the correlation between the level of the mutation process and the dose rate of chronic irradiation. The genetic effects of different levels of radioactive contamination were estimated by determining the frequency of mutations occurred in this generation and by calculating the dose of irradiation of one was found. That the dependence of the mutation frequency on the dose of irradiation presents a power function with a power index less 1, which suggests a higher efficiency of low radiation doses per unit dose. Possible explanations of this phenomenon are considered in the work. The studies of cytogenetic effects in chronically exposed Crepis tectorum populations in the zones of the Chernobyl accident showed that starting from the second year after the Chernobyl disaster there appeared plants with an altered karyotype and their frequency of chromosome aberrations correlates in root meristem cells. 相似文献
10.
L. E. Sal’nikova A. G. Chumachenko E. A. Akayeva G. I. Kuznetsova I. N. Vesnina N. Sh. Lapteva S. K. Abilev A. V. Rubanovich 《Russian Journal of Genetics》2010,46(12):1479-1485
Associations of polymorphism of seven detoxification genes and three genes of oxidative response with the frequency of chromosome
aberrations in human peripheral blood lymphocytes were studied. The genotyping data were correlated with the frequencies of
spontaneous and γ-induced (1 Gy in vitro) chromosome aberrations estimated for a group of healthy donors (97 males under 25
years of age) by analyzing 500–1000 metaphase cells per individual. The spontaneous level of chromosome-type aberrations was
reduced in homozygotes for the GSTM1 locus deletion, and especially in double homozygotes for deletions of the GSTM1 and GSTT1 genes. The frequency of γ-induced chromosome-type aberrations was reduced in G/G homozygotes for the minor allele of the
poorly studied CYP1A1 T606G site: 0.094 ± 0.006 against 0.112 ± 0.002 for T allele carriers (P = 0.004). Linkage of the T606G site with well known and functionally important sites of the CYP1A1 gene (A4889G, T3801C) was analyzed. 相似文献