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1.
2.
Pentane and ethane are degradation products of unsaturated fatty acids which are released during lipid peroxidation. In order to assess whether multiple sclerosis is associated with lipid peroxidation, we measured pentane and ethane excretion by 16 patients with multiple sclerosis and compared them to healthy control subjects. Patients with acute exacerbation of multiple sclerosis had significantly higher concentrations of pentane (10.5±4.2 nmol/l)(p<0.01) compared to either patients in remission (4.5±1.7 nmol/l) or control subjects (4.9±1.1 nmol/l). The concentrations of ethane were not significantly different among these groups. Of the patients with acute exacerbation who later achieved remission, the pentane excretion also returned to normal (5.6±0.9 nmol/l). One patient who failed to reachieve clinical remission continued to excrete large amounts of pentane. We conclude that oxygen free radical activity is enhanced during exacerbation multiple sclerosis. 相似文献
3.
Pradip Bhatnagar William Huffman Andrew King Louis Pelus William Potts et al. 《Journal of Ornithology》1994,135(1):61-71
Research Notes on Avian Biology 1994: Selected Contributions from the 21st International Ornithological CongressMorphology and Physiology: Endocrinology
Subject: Endocrinology and chronobiology 相似文献4.
H. N. Shahi 《Plant and Soil》1977,46(1):271-273
Summary Field studies conducted at the Haryana Agricultural University, Hissar, India for two years revealed thatChenopodium album L. contained very high degree of nitrogen, phosphorus, potassium, calcium, magnesium, iron and manganese. Its nutrient content declined with advancement in age of the plant. 相似文献
5.
Ferdinand Bohlmann Pradip K. Mahanta Arvind A. Natu Robert M. King Harold Robinson 《Phytochemistry》1978,17(3):471-474
The investigation of two Isocarpha species has yielded eight new germacranolides most of them belonging to the heliangolides. In addition to known p-hydroxyacetophenone-derivatives, a new dihydroeuparine derivative was isolated. The chemotaxonomical aspects are discussed. 相似文献
6.
From three Mikania species, three new labdanic acid and two kaurenic acid derivatives have been isolated together with known compounds and four new germacranolides, differing only in the ester moiety. 相似文献
7.
Lokesh Bhattacharyya Pradip Kumar Das A. Sen 《Archives of biochemistry and biophysics》1981,211(1):459-470
The lectins of the seeds of four species of the genus Erythrina, namely E. indica, E. arborescens, E. lithosperma, and E. suberosa were isolated by affinity chromatography on acid-treated ECD-Sepharose 6B. The lectins were found homogeneous in polyacrylamide gel electrophoresis and immunochemical tests. In SDS-gel electrophoresis, E. indica and E. lithosperma lectins each gave two bands with subunit molecular weights of 30,000 and 33,000 in the case of the former and 26,000 and 28,000 in the case of the latter. E. arborescens and E. suberosa gave single bands corresponding to polypetide chain molecular weight of 28,000. The lectins were found to be glycoproteins with their neutral sugar contents ranging from 4–9%. In carbohydrate specificity all the lectins were d-galactose specific. Their close similarity was also demonstrated by their homologous cross-reaction against the antiserum to E. indica lectin. In hemagglutinating activity toward human erythrocytes, E. indica and E. suberosa lectins showed higher activity toward the O group and E. arborescens toward the B group. The results show the similarity of the lectins derived from different species of the same genus in respect of immunochemical properties and carbohydrate specificity. In studies on E. indica lectin, the protein was found homogeneous by electrophoretic, immunochemical, and sedimentation experiments. Its molecular weight of 68,000 determined from sedimentation and diffusion data indicated that the molecule was a dimer of two noncovalently bound unequal subunits whose SDS-gel electrophoretic molecular weights are noted above. The lectin was devoid of cysteine and methionine and contained valine as its N-terminal amino acid. It had 9% neutral sugars and 1.5% glucosamine. Equilibrium dialysis studies with lactose showed that the values of the association constant K at different temperatures were of similar orders of magnitude to other lectins and the dimeric molecule possessed two noninteracting binding sites. 相似文献
8.
Summary Protoplasts from mesophyll cells and callus cells of rice (Oryza sativa L.) have been isolated by enzyme treatment involving 2% pectinase followed by 3% cellulase at pH 5.4 in 0.45 M mannitol (viable protoplasts from mesophyll cells in 50–60% yield, 60–70% yield of viable protoplasts from callus cells through treatment with the mixture of the above mentioned enzymes at the same concentration). Our completely defined medium is the combination of three established media (Table 1). Culture conditions are: soft agar in petri dishes at 26° C, where they regenerated cell walls after 24 h. The first cell division was observed after 4 days in culture for callus protoplasts and after 5 days in culture for mesophyll protoplasts. Cell division continues thereafter, and after 4 weeks of culture small white calli were visible in the petri dishes. The type of plant material (whitish leaf sheaths) and cell density are important factors for the efficiency of colony formation (30% plating efficiency). Healthy root formation through transfer to suitable medium is up to now the morphogenetic reaction of the calli.Work carried out at Molecular Cytogenetics Research Unit, Deptt, of Genetics and Plant Breeding, Banaras Hindu University, Varanasi, India 相似文献
9.
Bornali Chakrabarti Hridoy R Bairagya Deepak Kr Mishra Pradip Kumar Chatterjee Bishnu P Mukhopadhyay 《Bioinformation》2013,9(3):126-133
Human matrix metalloproteinase-8 (hMMP-8) plays a important role in the progression of colorectal cancer, metastasis, multiple
sclerosis and rheumetoid arthritis. Extensive MD-simulation of the PDB and solvated structures of hMMP-8 has revealed the
presence of few conserved water molecules around the catalytic and structural zinc (ZnC and ZnS) ions. The coordination of two
conserved water molecules (W and WS) to ZnS and the H-bonding interaction of WS to S151 have indicated the plausible involvement
of that metal ion in the catalytic process. Beside this the coupling of ZnC and ZnS metal ions (ZnC – WH (W1)…..W2 ….H162 - ZnS)
through two conserved hydrophilic centers (occupied by water molecules) may also provide some rational on the recognition of
two zinc ions which were separated by ~13 Å in their X-ray structures. This unique recognition of both the Zn+2 ions in the enzyme
through conserved water molecules may be implemented/ exploited for the design of antiproteolytic agent using water mimic
drug design protocol. 相似文献
10.
Oindrila Raha Biswanath Sarkar Bhaskar VKS Lakkakula Veerraju Pasumarthy Sudhakar Godi Subhankar Chowdhury Pradip Raychaudhuri Raghavendra Rao Vadlamudi 《Journal of biomedical science》2013,20(1):12