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1.
Pinhas Shlomai Ami Ben-Amotz Pinhas Margalith 《Applied microbiology and biotechnology》1991,34(4):458-462
Summary -Carotene steroisomers, mainly all-trans and to a small extent 9-cis, may be produced by the fungus Phycomyces blakesleeanus under normal fermentation conditions. The amount of the 9-cis--carotene may comprise up to 15% of the total -carotene. Similarly, cis-lycopene or-phytoene stereoisomers may be obtained when the fungus is fermented in the presence of specific -carotene inhibitors such as nicotine or diphenylamine respectively. This is the first report on the occurrence of cis-stereoisomers of carotenes in mycelial fungi. 相似文献
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Y. Stupp N. Manny Z. Shlomai N. Grover D. W. Weiss G. Izak 《Cancer immunology, immunotherapy : CII》1978,3(3):189-193
Summary MER administered prophylactically prolonged the survival of BALB/c mice challenged with transplants of syngeneic plasmacytomas to a moderate but significant extent. In contrast, MER exerted little therapeutic action when given alone at or after tumor implantation.Combined treatment, with MER introduced prophylactically and cyclophopshamide (CY) after tumor implantation, decreased the incidence of recurrence of one of the tumors tested (MPC-11 NP, a non-myeloma protein producer) and prolonged host survival significantly as compared with animals subjected to CY therapy alone. When, instead, MER was introduced at the time of tumor challenge or thereafter to animals also treated with CY, the therapeutic response was not appreciably different from that of mice under therapy with CY only. With regard to the second plasmacytoma (MPC-11 P, a myeloma protein producer), mice treated with CY and given MER prior to or after challenge showed similar responses to animals given chemotherapy only; when MER was injected at the time of challenge and CY thereafter, the chemoimmunotherapy was somewhat inferior to chemotherapy alone.This work was supported by US Public Health Service Contract NO1-CM-12127, and by grants from Mrs. J. H. Hazen, Ruth Estrin Goldberg Memorial for Cancer Research, Leukemia Research Foundation, Inc., Concern Foundation, Inc., and Mr. and Mrs. M. Gordon 相似文献
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A number of chemical compounds are known to affect the biosynthetic pathways of β-carotene. Both site-specific inhibitors as well as general stimulators of carotenogenesis have been described. It has been reported that veratrole enhances β-carotene synthesis when applied to agar cultures of Phycomyces blakesleeanus but we found no significant stimulation of β-carotene production in submerged culture. Moreover, veratrole in high concentrations (> 0.1% w/v), unlike diphenylamine, inhibits the formation of phytoene, resulting in an almost total block of carotenoid biosynthesis. 相似文献
4.
A prepriming DNA replication enzyme of Escherichia coli. II. Actions of protein n': a sequence-specific, DNA-dependent ATPase 总被引:3,自引:0,他引:3
Protein n' of Escherichia coli is required for formation of the prepriming complex in replication of the single-stranded circle of phiX174 DNA. The protein, purified to near homogeneity, possesses ATPase (dATPase) activity in the presence of single-stranded, but not duplex, DNAs. Except for phiX174 DNA, ATPase activity is completely suppressed by coating the DNA with single strand binding protein (SSB). phiX174 DNA possesses a unique sequence with a potential hairpin structure that is recognized as an effector (Shlomai, J., and Kornberg, A. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 799-803). Sequences with secondary structure in SSB-coated M13 DNA which are recognized by RNA polymerase, and in coated G4 DNA by primase, are inert for protein n'. Approximately 30 of the 180 molecules of SSB bound to phiX DNA are destabilized by protein n' in an ATP-dependent reaction. These actions by protein n' may be important in recognizing an origin for forming the prepriming complex that leads to initiation of phiX complementary strand synthesis. 相似文献
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Characterization of hereditary inclusion body myopathy myoblasts: possible primary impairment of apoptotic events 总被引:1,自引:0,他引:1
Amsili S Shlomai Z Levitzki R Krause S Lochmuller H Ben-Bassat H Mitrani-Rosenbaum S 《Cell death and differentiation》2007,14(11):1916-1924
Hereditary inclusion body myopathy (HIBM) is a unique muscular disorder caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene. GNE encodes a bi-functional enzyme acting in the biosynthetic pathway of sialic acid. Since the underlying myopathological mechanism leading to the disease phenotype is poorly understood, we have established human myoblasts cultures, derived from HIBM satellite cells carrying the homozygous M712T mutation, and identified cellular and molecular characteristics of these cells. HIBM and control myoblasts showed similar heterogeneous patterns of proliferation and differentiation. Upon apoptosis induction, phosphatidylserine externalization was similar in HIBM and controls. In contrast, the active forms of caspase-3 and -9 were strongly enhanced in most HIBM cultures compared to controls, while pAkt, downregulated in controls, remained high in HIBM cells. These results could indicate impaired apoptotic signaling in HIBM cells. Since satellite cells enable partial regeneration of the post-mitotic muscle tissue, these altered processes could contribute to the muscle mass loss seen in patients. The identification of survival defects in HIBM affected muscle cells could disclose new functions for GNE in muscle cells. 相似文献
8.
Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40x protein and bovine papilloma virus encoded E2 protein. 总被引:33,自引:1,他引:33 下载免费PDF全文
S Miyatake M Seiki R D Malefijt T Heike J Fujisawa Y Takebe J Nishida J Shlomai T Yokota M Yoshida 《Nucleic acids research》1988,16(14A):6547-6566
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The accumulation of a fluid property from the standpoint of a particle moving with non-steady fluid flow (i.e., platelet/blood-cell damage index in pulsating blood flow) is a challenged computational problem due to the current need for particle-tracing methods. The method we developed (dubbed VPI) enables the approximation of the Lagrangian integral in real-time for any point in space and time for the entire domain and which is easily integrated into the the lattice Boltzmann method. As an illustrative numerical example we applied our method to a blood coagulation model which was shown to accurately capture the coagulation characteristics observed in experiments, and therefore opening a door for more detailed study of systems which are currently hard to study using particle tracing methods. 相似文献