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Shima Moradi-Kalbolandi Mahdi Habibi-Anbouhi Majid Golkar Mahdi Behdani Gashin Rezaei Leila Ghazizadeh Mohsen Abolhassani Mohammad Ali Shokrgozar 《Analytical biochemistry》2016
Antibody engineering involves a range of custom modifications of immunoglobulins to improve their affinity, valency, and pharmacokinetics, ensuring a better target therapy achievement. A number of therapeutic antibodies have been used for cell surface receptor blockage, interfering with the ligand binding and inhibiting receptor-driven activation of cells. Here we describe the construction and characterization of a recombinant bivalent single-chain Fv (biscFv) that targets CD123. On conversion of anti-CD123 scFv to biscFv format, the recognition of the cognate ligand is not altered. Moreover, the increased overall efficacy of the anti-CD123 biscFv in binding and inhibition of CD123/IL-3 (interleukin-3) interactions in TF-1 cells is demonstrated. 相似文献
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Moradi-Kalbolandi Shima Dashtestani Fariba Salehi Malihe Jalili Neda Majidzadeh-A Keivan Rahighi Reza Yadegari Amir Farahmand Leila 《Molecular biology reports》2020,47(1):225-234
Molecular Biology Reports - Leukemic cancer stem cells (LSCs), aberrantly overexpressing CD45RA are among the major causes of relapse following chemotherapy in patients with acute myeloid leukemia... 相似文献
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