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1.
Milena Riesová-Kučerová 《Biologia Plantarum》1969,11(5):338-346
The dependence of the frequency of recessive lethal (two groups), chlorophyll and morphological mutations on the mutagen concentration was determined in M2 after subjection to N-nitroso-N-methylurea applied to seeds ofArabidopsis in three concentrations (0·05, 0·10 and 0·20mm). The observed frequencies were compared with the theoretically expected ones for the linear and for two exponential types of dependence, by using the t-test, according to the formulas m=k. C, m=k. C3/2, m=k. C2. No satisfactory agreement with any expected type of dependence was found when directly observed frequencies were used. Since a considerable deficit of mutation frequency was observed in high concentrations, the correction of frequency values was done with respect to the probability of occurence of double mutations. After such a correction, a clear exponential relation was found in both types of lethals and a linear one in chlorophyll and morphological mutations. The probable occurence of multiple mutations should be, therefore, taken into account if the dependence of mutation frequency on the concentration of mutagen is discussed. 相似文献
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Fabrizio Villani Milena Galimberti Elena Monti Francesco Piccinini Enrica Lanza Annalinda Rozza Luigia Favalli Paola Poggi Franco Zunino 《Free radical research》1990,11(1):145-151
The effects of two sulfhydryl compounds, glutathione (GSH) and N-acetylcysteine (NAC), on the cardiotoxicity of doxorubicin (DXR) were tested on in vitro and in vivo models. DXR was administered to rats as 4 weekly i.v. doses of 3mg/kg. GSH (1.5 mmoles/kg), given i.v. 10 min before and 1 hr after DXR, was found to prevent the development of the delayed cardiotoxic effects of DXR, as assessed by electrocardiographic and mechanical parameters, as well as by histological examination of left ventricular preparations. In contrast, equimolar oral doses of NAC (1 hr before and 2hrs after DXR) were found to be ineffective. Both GSH and NAC prevented the negative inotropic effect produced by DXR on isolated rat atria. A good correlation exists between the cardioprotective effects of the two agents and their ability to enhance the non-protein sulfhydryl group content of the myocardium. Differences observed in vivo between GSH and NAC might be accounted for by pharmacokinetic factors. 相似文献
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Milena Lima de Moraes Renata de Faria Barbosa Raquel Espírito Santo Flávia da Silva Santos Edgar Francisco Oliveira de Jesus Fátima Lúcia de Carvalho Sardinha Maria das Graças Tavares do Carmo 《Biological trace element research》2011,139(2):126-136
Adolescence is marked by intensive growth and development. When pregnancy occurs during this period of the mother’s growth,
there is an increase in her nutritional needs. The aim of this study was to determine the levels of calcium, iron, copper,
and zinc in maternal plasma, the placenta, and in the cord plasma of pregnant teenagers and adults. A total of 80 sets of
maternal plasma, placentas, and cord plasma (40 from teenagers and 40 from adults) were analyzed using synchrotron radiation
total reflection X-ray fluorescence. The levels of calcium, copper, and zinc in the maternal and cord plasma from teenagers
were not significantly different than those from adults. Iron levels in the teenagers maternal and cord plasma were higher
than in the adults. All of the minerals analyzed were present at higher levels in the placentas from adults than those from
teenagers. However, the low quantities of placental calcium, iron, copper, and zinc in the teenagers do not compromise the
levels of these minerals in the cord plasma. Future research regarding the placental transport of these minerals is recommended
to investigate the efficiency of mechanisms of transfer of these minerals in pregnant teenagers. 相似文献
6.
Solveig Herrmann Milena Ninkovic Tobias Kohl éva L?rinczi Luis A. Pardo 《The Journal of biological chemistry》2012,287(53):44151-44163
KV10.1 is a voltage-gated potassium channel aberrantly expressed in many cases of cancer, and participates in cancer initiation and tumor progression. Its action as an oncoprotein can be inhibited by a functional monoclonal antibody, indicating a role for channels located at the plasma membrane, accessible to the antibody. Cortactin is an actin-interacting protein implicated in cytoskeletal architecture and often amplified in several types of cancer. In this study, we describe a physical and functional interaction between cortactin and KV10.1. Binding of these two proteins occurs between the C terminus of KV10.1 and the proline-rich domain of cortactin, regions targeted by many post-translational modifications. This interaction is specific for KV10.1 and does not occur with KV10.2. Cortactin controls the abundance of KV10.1 at the plasma membrane and is required for functional expression of KV10.1 channels. 相似文献
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María José Arauz Valéry Ridde Libia Milena Hernández Yaneth Charris Mabel Carabali Luis ángel Villar 《PloS one》2015,10(2)
BackgroundDengue fever is a public health problem in the tropical and sub-tropical world. Dengue cases have grown dramatically in recent years as well as dengue mortality. Colombia has experienced periodic dengue outbreaks with numerous dengue related-deaths, where the Santander department has been particularly affected. Although social determinants of health (SDH) shape health outcomes, including mortality, it is not yet understood how these affect dengue mortality. The aim of this pilot study was to develop and pre-test a social autopsy (SA) tool for dengue mortality.ConclusionsThe SA tool is based on the scientific literature, a validated conceptual framework, researchers’ and health professionals’ expertise, and a pilot study. It is the first time that a SA tool has been created for the dengue mortality context. Our work furthers the study on SDH and how these are applied to neglected tropical diseases, like dengue. This tool could be integrated in surveillance systems to provide complementary information on the modifiable and avoidable death-related factors and therefore, be able to formulate interventions for dengue mortality reduction. 相似文献
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Increased Chondrogenic Potential of Mesenchymal Cells From Adipose Tissue Versus Bone Marrow‐Derived Cells in Osteoarthritic In Vitro Models 下载免费PDF全文
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