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1.
Hashemzadeh Segherloo Iraj Ghojoghi Fariborz Tabatabaei Seyedeh Narjes Normandeau Eric Hernandez Cecilia Hallerman Eric Boyle Brian Bernatchez Louis 《Hydrobiologia》2021,848(2):345-361
Hydrobiologia - The genus Rutilus is widespread in the western and central Palearctic region. In the Caspian Sea, the taxonomic status of different populations of Rutilus lacustris has... 相似文献
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Tabatabaei Seyedeh Narjes Abdoli Asghar Hashemzadeh Segherloo Iraj Normandeau Eric Ahmadzadeh Faraham Nejat Farshad Bernatchez Louis 《Hydrobiologia》2020,847(16):3339-3353
Hydrobiologia - Many populations of Caspian Sea trout (Salmo caspius)—a nationally endangered species in Iran—have been extirpated or depleted due to anthropogenic impacts. The Lar... 相似文献
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Elham Safarzadeh Shahryar Hashemzadeh Pascal H.G. Duijf Behzad Mansoori Vahid Khaze Ali Mohammadi Tohid Kazemi Mehdi Yousefi Milad Asadi Hamed Mohammadi Farhad Babaie Behzad Baradaran 《Journal of cellular physiology》2019,234(4):3515-3525
Evading immune destruction is a hallmark of cancer. Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of myeloid immune cells, are thought to foster the establishment of an immunosuppressive tumor microenvironment, but it remains unclear how. This study aims to determine the levels of circulating MDSCs and their subpopulations and test their immunosuppressive functions in patients with breast cancer (BC). We analyzed the fractions of MDSCs in freshly isolated peripheral blood mononuclear cells of patients with BC and healthy donors using flow cytometry. Circulating MDSCs were further phenotyped using fluorescently labeled antihuman monoclonal antibodies. Coculture experiments revealed the effects of MDSCs on CD3+ T cell response. Moreover, we correlated circulating MDSC levels with clinicopathological features of patients with BC. We show that the fraction of HLA-DR – CD33 + MDSCs in peripheral blood is about 10-fold higher in patients with BC than in healthy control individuals. The levels of all MDSC subpopulations, including monocytic and granulocytic MDSCs, are significantly elevated. Coculture experiments of purified HLA-DR – CD33 + MDSCs and CD3 + T cells demonstrate that T cell proliferation is more effectively inhibited by BC patient-derived MDSCs than by healthy control MDSCs. Moreover, increased circulating MDSC levels robustly associate with advanced BC stage and positive lymph node status. By being more abundant and more effective T cell suppressors, BC patient-derived circulating MDSCs exert a dual immunosuppressive effect. Our findings pave the way to develop novel diagnostic and immunotherapeutic strategies, aimed at detecting and inhibiting MDSCs in patients with BC. 相似文献
4.
Heidari Reza Farajzadeh Sheikh Ahmad Hashemzadeh Mohammad Farshadzadeh Zahra Salmanzadeh Shokrollah Saki Morteza 《Molecular biology reports》2022,49(5):3811-3822
Molecular Biology Reports - This study was aimed to evaluate the antibiotic resistance, biofilm formation, and genetic diversity of carbapenem-resistant Pseudomonas aeruginosa (CRPA) strains... 相似文献
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Bakhtiyariniya Pejman Khosravi Azar Dokht Hashemzadeh Mohammad Savari Mohammad 《Molecular biology reports》2022,49(7):6135-6143
Molecular Biology Reports - The global rise in drug-resistant Mycobacterium tuberculosis (M.tb), and especially the significant prevalence of isoniazid (INH)-resistance constitute a significant... 相似文献
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Jafar Rezaie Reza Rahbarghazi Milad Pezeshki Mahdi Mazhar Farshid Yekani Majid Khaksar Elhameh Shokrollahi Hassan Amini Shahriar Hashemzadeh Sadiye Emel Sokullu Mehmet Tokac 《Journal of cellular physiology》2019,234(12):21732-21745
Extracellular vesicles (EVs) are nano-sized vesicles, released from many cell types including cardiac cells, have recently emerged as intercellular communication tools in cell dynamics. EVs are an important mediator of signaling within cells that influencing the functional behavior of the target cells. In heart complex, cardiac cells can easily use EVs to transport bioactive molecules such as proteins, lipids, and RNAs to the regulation of neighboring cell function. Cross-talk between intracardiac cells plays pivotal roles in the heart homeostasis and in adaptive responses of the heart to stress. EVs were released by cardiomyocytes under baseline conditions, but stress condition such as hypoxia intensifies secretome capacity. EVs secreted by cardiac progenitor cells and cardiosphere-derived cells could be pinpointed as important mediators of cardioprotection and cardiogenesis. Furthermore, EVs from many different types of stem cells could potentially exert a therapeutic effect on the damaged heart. Recent evidence shows that cardiac-derived EVs are rich in microRNAs, suggesting a key role in the controlling of cellular processes. EVs harboring exosomes may be clinically useful in cell-free therapy approaches and potentially act as prognosis and diagnosis biomarkers of cardiovascular diseases. 相似文献
8.
Banoei MM Chaleshtori MH Sanati MH Shariati P Houshmand M Majidizadeh T Soltani NJ Golalipour M 《Human biology; an international record of research》2008,80(1):73-81
Variation of a VNTR in the DAT1 gene in seven ethnic groups of the Middle East was used to infer the history and affinities of these groups. The populations consisted of Assyrian, Jewish, Zoroastrian, Armenian, Turkmen, and Arab peoples of Iran, Iraq, and Kuwait. Three hundred forty subjects from these seven ethnic groups were screened for DAT1. DAT1 VNTR genotyping showed 3, 6, 7, 8, 9, 10, 11, and 12 alleles in the samples. Analysis of these data revealed differentiation and relationship among the populations. In this region, which covers an area of 2-2.5 million km2, the influence of geography and especially of linguistic characteristics has had potentially major effects on differentiation. Religion also has played a major role in imposing restrictions on some ethnic groups, who as a consequence have maintained their community. Overall, these ethnic groups showed greater heterogeneity compared to other populations. 相似文献
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Fatemeh Ghanavatinejad Zahra Pourteymourfard‐Tabrizi Karim Mahnam Abbas Doosti Ameneh Mehri‐Ghahfarrokhi Masoumeh Pourhadi Sayedeh Azimeh Hosseini Morteza Hashemzadeh Chaleshtori Payam Soltanzadeh Mohammad‐Saeid Jami 《Cell biology international》2020,44(2):671-683
Charcot‐Marie‐Tooth (CMT) diseases are a heterogeneous group of genetic peripheral neuropathies caused by mutations in a variety of genes, which are involved in the development and maintenance of peripheral nerves. Myelin protein zero (MPZ) is expressed by Schwann cells, and MPZ mutations can lead to primarily demyelinating polyneuropathies including CMT type 1B. Different mutations demonstrate various forms of disease pathomechanisms, which may be beneficial in understanding the disease cellular pathology. Our molecular dynamics simulation study on the possible impacts of I30T mutation on the MPZ protein structure suggested a higher hydrophobicity and thus lower stability in the membranous structures. A study was also conducted to predict native/mutant MPZ interactions. To validate the results of the simulation study, the native and mutant forms of the MPZ protein were separately expressed in a cellular model, and the protein trafficking was chased down in a time course pattern. In vitro studies provided more evidence on the instability of the MPZ protein due to the mutation. In this study, qualitative and quantitative approaches were adopted to confirm the instability of mutant MPZ in cellular membranes. 相似文献
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Hashemzadeh Pejman Ghorbanzadeh Vajihe Lashgarian Hamed Esmaeil Kheirandish Farnaz Dariushnejad Hassan 《International journal of peptide research and therapeutics》2020,26(3):1417-1428
International Journal of Peptide Research and Therapeutics - Kala-azar or visceral leishmaniasis (VL) is the most important vector-borne protozoan disease and a life-threatening problem in the... 相似文献