全文获取类型
收费全文 | 272篇 |
免费 | 25篇 |
专业分类
297篇 |
出版年
2021年 | 5篇 |
2020年 | 3篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 11篇 |
2013年 | 7篇 |
2012年 | 8篇 |
2011年 | 6篇 |
2010年 | 11篇 |
2009年 | 5篇 |
2008年 | 10篇 |
2007年 | 5篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 3篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 7篇 |
2000年 | 6篇 |
1999年 | 7篇 |
1998年 | 3篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 7篇 |
1993年 | 3篇 |
1992年 | 8篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 7篇 |
1986年 | 4篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 7篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1967年 | 4篇 |
1962年 | 3篇 |
1961年 | 4篇 |
1959年 | 2篇 |
1958年 | 6篇 |
1955年 | 2篇 |
1952年 | 3篇 |
1879年 | 2篇 |
排序方式: 共有297条查询结果,搜索用时 15 毫秒
1.
R M Sweeting B A McKeown 《Comparative biochemistry and physiology. A, Comparative physiology》1987,88(1):147-151
1. Effects of growth hormone (GH) were examined on short-term aspects of seawater adaptation in coho salmon smolts. 2. Injection of somatostatin (SRIF) immediately prior to seawater entry suppressed plasma GH levels, but did not have any significant effects at 6 or 12 hr on hematocrits, plasma glucose or plasma Na+ levels. 3. Plasma GH levels increased 250% within 36 hr after seawater exposure. 4. Plasma glucose levels, in contrast, were significantly lower in the seawater fish after 36 hr post-exposure. 5. Plasma Na+ levels increased to 190 mEq/1 by 24 hr but subsequently returned to freshwater levels while hematocrits showed no significant changes over the 72 hr of exposure. 6. The significance of these results is discussed in terms of successful seawater adaptation in coho salmon. 相似文献
2.
3.
Injections of arginine vasotocin into bullfrogs had no effect on plasma glucose after 30 min. but caused hyperplycemia after 120 min. Plasma levels of growth hormone were elevated earlier (30 min.) and returned to control levels after 120 min. Plasma free fatty acids were unaltered following vasotocin administration. It is suggested that the hyperglycemic effect of vasotocin may be mediated via growth hormone. 相似文献
4.
Evidence for sub-families of actin genes in Dictyostelium as determined by comparisons of 3' end sequences 总被引:13,自引:0,他引:13
We have sequenced the 3′ end of five actin genomic clones and three actin complementary DNA clones from Dictyostelium. Comparison of the sequences shows that the protein coding regions are highly conserved, while the region corresponding to the 3′ untranslated regions are divergent. Additional analysis indicates regions of homology in the 3′ untranslated region between sets of actin genes. Southern DNA blot hybridization studies using labeled 3′ ends suggest that there are sub-families of actin genes that are related within the 3′ untranslated regions. No homology is found in the sequences outside the messenger RNA encoding regions. Analysis of the sequence data has shown that the difference in length between the ~1.25 × 103 and ~1.35 × 103 base actin messenger RNAs is in the lengths of the 3′ untranslated region. 相似文献
5.
K. J. Brewer B. A. McKeown 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》1980,140(3):217-225
Summary Parr and smolt sea water acclimated coho salmon,Oncorhynchus kisutch were subjected to gradual and direct transfers to fresh water. Plasma osmotic pressure, Na+, K+, Ca++ and Mg++ were similar in freshwater (FW) fish and seawater (SW) transferred controls for the 24 h following transfer. In spite of the similarity in osmotic pressure and ion levels, plasma cortisol concentrations were significantly increased immediately following salinity change while both pituitary and plasma prolactin decreased indicating enhanced secretion by the pituitary and clearance from the blood. In vitro experiments showed greater incorporation of tritiated leucine into prolactin (PRL) cells immediately after transfer to FW while prolactin injections into intact fish lowered activity in rostral pars distalis (RPD) cells as measured by the same technique, providing evidence of hormonal feedback. These experiments show that the increased synthesis and release of PRL that occurs in coho following movement into FW is not obviously correlated with plasma osmotic pressure, Na+ or Ca++ concentrations as has been observed in other species of teleosts.Abbreviations
FW
freshwater
-
SW
seawater
-
PRL
prolactin
-
RPD
rostral pars distalis 相似文献
6.
7.
Synthesis and activity of small molecule GPR40 agonists 总被引:2,自引:0,他引:2
Garrido DM Corbett DF Dwornik KA Goetz AS Littleton TR McKeown SC Mills WY Smalley TL Briscoe CP Peat AJ 《Bioorganic & medicinal chemistry letters》2006,16(7):1840-1845
The first report on the identification and structure-activity relationships of a novel series of GPR40 agonists based on a 3-(4-{[N-alkyl]amino}phenyl)propanoic acid template is described. Structural modifications to the original screening hit yielded compounds with a 100-fold increase in potency at the human GPR40 receptor and pEC(50)s in the low nanomolar range. The carboxylic acid moiety is not critical for activity but typically elicits an agonistic response higher than those observed with carboxamide replacements. These compounds may prove useful in unraveling the therapeutic potential of this receptor for the treatment of Type 2 diabetes. 相似文献
8.
David C Zappulla Arindel SR Maharaj Jessica J Connelly Rebecca A Jockusch Rolf Sternglanz 《BMC molecular biology》2006,7(1):40-12
Background
By screening a plasmid library for proteins that could cause silencing when targeted to the HMR locus in Saccharomyces cerevisiae, we previously reported the identification of Rtt107/Esc4 based on its ability to establish silent chromatin. In this study we aimed to determine the mechanism of Rtt107/Esc4 targeted silencing and also learn more about its biological functions. 相似文献9.
10.
Catherine Murphy Sarah Hotchkiss Jenny Worthington Stephanie R. McKeown 《Journal of applied phycology》2014,26(5):2211-2264
This review discusses studies on marine macroalgae that have been investigated for their potential as sources of novel anti-cancer drugs. The review highlights the very large number of studies of crude, partially purified and purified seaweed extracts, collected from many locations, which have shown potential as sources of potent anti-cancer drugs when tested in vitro and/or in vivo. The activity of polysaccharides, polyphenols, proteinaceous molecules, carotenoids, alkaloids, terpenes and others is described here. In some reports, mechanistic studies have identified specific inhibitory activity on a number of key cellular processes including apoptosis pathways, telomerase and tumour angiogenesis. However, despite the potential shown by these studies, translation to clinically useful preparations is almost non-existent. It is hoped this review will serve as a source document and guide for those carrying out research into the potential use of macroalgae as a source of novel anti-cancer agents. 相似文献