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1.
Luke L. M. Heaton Eduardo López Philip K. Maini Mark D. Fricker Nick S. Jones 《Proceedings. Biological sciences / The Royal Society》2010,277(1698):3265-3274
Cord-forming fungi form extensive networks that continuously adapt to maintain an efficient transport system. As osmotically driven water uptake is often distal from the tips, and aqueous fluids are incompressible, we propose that growth induces mass flows across the mycelium, whether or not there are intrahyphal concentration gradients. We imaged the temporal evolution of networks formed by Phanerochaete velutina, and at each stage calculated the unique set of currents that account for the observed changes in cord volume, while minimizing the work required to overcome viscous drag. Predicted speeds were in reasonable agreement with experimental data, and the pressure gradients needed to produce these flows are small. Furthermore, cords that were predicted to carry fast-moving or large currents were significantly more likely to increase in size than cords with slow-moving or small currents. The incompressibility of the fluids within fungi means there is a rapid global response to local fluid movements. Hence velocity of fluid flow is a local signal that conveys quasi-global information about the role of a cord within the mycelium. We suggest that fluid incompressibility and the coupling of growth and mass flow are critical physical features that enable the development of efficient, adaptive biological transport networks. 相似文献
2.
3.
Biological control of eggplant pests in general, and (CPB)Leptinotarsa decemlineata (Say) in particular, is highly problematic.Edovum puttleri Grissell, an exotic egg parasitoid which has been found potentially effective, is being reared to this end. Frozen CPB eggs (?18°C) proved to be accepted and suitable for parasitization byE. puttleri. However, when given a choice between 20 frozen and 20 normal eggs every 2 days, the females exhibited a significant preference for the latter. Parasitization and host predation patterns related to female age are described by 2 opposing fourth-order polynomial functions. Parasitization increased up to day 10, followed by progressive decline. Average life span per female was 31.10±.58, with a recorded maximum of 56 days. High predatory behaviour of older females, which showed a decrease in parasitization, was observed in these experimental conditions. 相似文献
4.
Luke Olsen Jonathan A. Sherratt Philip K. Maini 《Bulletin of mathematical biology》1996,58(4):787-808
The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic
scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic
cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current
medical treatments are thus unreliable.
In this paper, the authors apply an existing deterministic mathematical model for fibroplasia and wound contraction in adult
mammalian dermis (Olsenet al., J. theor. Biol.
177, 113–128, 1995) to investigate key clinical problems concerning these healing disorders. A caricature model is proposed which
retains the fundamental cellular and chemical components of the full model, in order to analyse the spatiotemporal dynamics
of the initiation, progression, cessation and regression of fibro-contractive diseases in relation to normal healing. This
model accounts for fibroblastic cell migration, proliferation and death and growth-factor diffusion, production by cells and
tissue removal/decay.
Explicit results are obtained in terms of the model processes and parameters. The rate of cellular production of the chemical
is shown to be critical to the development of a stable pathological state. Further, cessation and/or regression of the disease
depend on appropriate spatiotemporally varying forms for this production rate, which can be understood in terms of the bistability
of the normal dermal and pathological steady states—a central property of the model, which is evident from stability and bifurcation
analyses.
The work predicts novel, biologically realistic and testable pathogenic and control mechanisms, the understanding of which
will lead toward more effective strategies for clinical therapy of fibro-proliferative disorders. 相似文献
5.
In this paper we use a dynamical systems approach to prove the existence of a unique critical value c
* of the speed c for which the degenerate density-dependent diffusion equation u
ct
= [D(u)u
x
]
x
+ g(u) has: 1. no travelling wave solutions for 0 < c < c
*, 2. a travelling wave solution u(x, t) = (x - c
*
t) of sharp type satisfying (– ) = 1, () = 0 *; '(*–) = – c
*/D'(0), '(*+) = 0 and 3. a continuum of travelling wave solutions of monotone decreasing front type for each c > c
*. These fronts satisfy the boundary conditions (– ) = 1, '(– ) = (+ ) = '(+ ) = 0. We illustrate our analytical results with some numerical solutions. 相似文献
6.
A C Keat R N Maini G C Nkwazi G D Pegrum G L Ridgway J T Scott 《BMJ (Clinical research ed.)》1978,1(6113):605-607
Inflammatory arthritis, tendinitis, and fasciitis after non-specific urethritis ("sexually acquired reactive arthritis" (SARA)) was studied prospectively in 531 men with non-specific urethritis, with particular reference to the frequency of isolation of Chlamydia trachomatis and the presence of HLA-B27. Satisfactory cultures were obtained from the urethral swabs from 384 patients; and HLA typing was performed on 482, of whom 30 (6%) were HLA-B27-positive. Arthritis developed in 16 patients, and five of the 14 (36%) with satisfactory cultures were positive for C trachomatis; 135 of the patients without arthritis were also positive for C trachomatis, an identical proportion. Seven of the 15 patients (40%) with arthritis who were HLA-typed were HLA-B27-positive. Six of the 30 patients with HLA-B27 developed peripheral arthritis in contrast to only nine of the 452 patients lacking the antigen, suggesting a tenfold increase susceptibility. C trachomatis, however, was no more prevalent in cultures from HLA-B27-positive men than from the others. Thus carriage of C trachomatis is unlikely to be influenced by HLA-B27. C trachomatis may be an important pathogen in some cases of SARA but does not appear to be an exclusive trigger factor for this condition. 相似文献
7.
C. Tonini G. Cassani P. Piccardi S. Maini P.L. Castellari E. Pasqualini 《Journal of insect physiology》1982,28(5):443-446
Female-tip washings of the leafroller moth, Pandemis cerasana, were found to contain (E)-11-tetradecenyl acetate, (Z)-11-tetradecenyl acetate, (E)-11-tetradecenol, (Z)-11-tetradecenol and tetradecyl acetate, based on chemical analysis and electroantennogram tests. The relative amounts of these compounds in the gland were ca. 64:21:10:3:2 in the order named. Only (E)-11 and (Z)-11-tetradecenyl acetate were required for attraction of males to trap dispensed in the ratio 3:1, respectively. 相似文献
8.
Himadri Mukhopadhyay Shaun-Paul Cordoba Philip K. Maini P. Anton van der Merwe Omer Dushek 《PLoS computational biology》2013,9(3)
Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on multiple immunoreceptor tyrosine-based activation motifs (ITAMs). Intriguingly, Lck sequentially phosphorylates ITAMs and ZAP-70, a cytosolic kinase, binds to phosphorylated ITAMs with differential affinities. The purpose of multiple ITAMs, their sequential phosphorylation, and the differential ZAP-70 affinities are unknown. Here, we use a systems model to show that this signaling architecture produces emergent ultrasensitivity resulting in switch-like responses at the scale of individual TCRs. Importantly, this switch-like response is an emergent property, so that removal of multiple ITAMs, sequential phosphorylation, or differential affinities abolishes the switch. We propose that highly regulated TCR phosphorylation is achieved by an emergent switch-like response and use the systems model to design novel chimeric antigen receptors for therapy. 相似文献
9.
Gabriel Rosser Alexander G. Fletcher David A. Wilkinson Jennifer A. de Beyer Christian A. Yates Judith P. Armitage Philip K. Maini Ruth E. Baker 《PLoS computational biology》2013,9(10)
Tracking bacteria using video microscopy is a powerful experimental approach to probe their motile behaviour. The trajectories obtained contain much information relating to the complex patterns of bacterial motility. However, methods for the quantitative analysis of such data are limited. Most swimming bacteria move in approximately straight lines, interspersed with random reorientation phases. It is therefore necessary to segment observed tracks into swimming and reorientation phases to extract useful statistics. We present novel robust analysis tools to discern these two phases in tracks. Our methods comprise a simple and effective protocol for removing spurious tracks from tracking datasets, followed by analysis based on a two-state hidden Markov model, taking advantage of the availability of mutant strains that exhibit swimming-only or reorientating-only motion to generate an empirical prior distribution. Using simulated tracks with varying levels of added noise, we validate our methods and compare them with an existing heuristic method. To our knowledge this is the first example of a systematic assessment of analysis methods in this field. The new methods are substantially more robust to noise and introduce less systematic bias than the heuristic method. We apply our methods to tracks obtained from the bacterial species Rhodobacter sphaeroides and Escherichia coli. Our results demonstrate that R. sphaeroides exhibits persistence over the course of a tumbling event, which is a novel result with important implications in the study of this and similar species. 相似文献
10.