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Iron is essential for the normal functioning of cells but since it is also capable of generating toxic reactive oxygen species,
the metabolism of iron is tightly regulated. The present article advances the view that astrocytes are largely responsible
for distributing iron in the brain. Capillary endothelial cells are separated from the neuropil by the endfeet of astrocytes,
so astrocytes are ideally positioned to regulate the transport of iron to other brain cells and to protect them if iron breaches
the blood-brain barrier. Astrocytes do not appear to have a high metabolic requirement for iron yet they possess transporters
for transferrin, haemin and non-transferrin-bound iron. They store iron efficiently in ferritin and can export iron by a mechanism
that involves ferroportin and ceruloplasmin. Since astrocytes are a common site of abnormal iron accumulation in ageing and
neurodegenerative disorders, they may represent a new therapeutic target for the treatment of iron-mediated oxidative stress. 相似文献
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Walker CA Köppe M Grenville-Briggs LJ Avrova AO Horner NR McKinnon AD Whisson SC Birch PR van West P 《Fungal genetics and biology : FG & B》2008,45(6):954-962
The asexual multinucleated sporangia of Phytophthora infestans can germinate directly through a germ tube or indirectly by releasing zoospores. The molecular mechanisms controlling sporangial cytokinesis or sporangial cleavage, and zoospore release are largely unknown. Sporangial cleavage is initiated by a cold shock that eventually compartmentalizes single nuclei within each zoospore. Comparison of EST representation in different cDNA libraries revealed a putative ATP-dependent DEAD-box RNA-helicase gene in P. infestans, Pi-RNH1, which has a 140-fold increased expression level in young zoospores compared to uncleaved sporangia. RNA interference was employed to determine the role of Pi-RNH1 in zoospore development. Silencing efficiencies of up to 99% were achieved in some transiently-silenced lines. These Pi-RNH1-silenced lines produced large aberrant zoospores that had undergone partial cleavage and often had multiple flagella on their surface. Transmission electron microscopy revealed that cytoplasmic vesicles fused in the silenced lines, resulting in the formation of large vesicles. The Pi-RNH1-silenced zoospores were also sensitive to osmotic pressure and often ruptured upon release from the sporangia. These findings indicate that Pi-RNH1 has a major function in zoospore development and its potential role in cytokinesis is discussed. 相似文献
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Maico LM Burrows AM Mooney MP Siegel MI Bhatnagar KP Smith TD 《Acta biologica Hungarica》2003,54(3-4):263-273
Most studies on mammalian vomeronasal organ (VNO) have been on laboratory-bred animals. Our present study examines the VNO in wild-caught meadow voles (Microtus pennsylvanicus: n=16) and prairie voles (M. ochrogaster: n=15). These species vary in their mating strategies and degree of parental care by males. M. ochrogaster exhibits pair bonding and more paternal care compared to M. pennsylvanicus, a promiscuous species. We hypothesize that sexual dimorphism will occur in the promiscuous species based on previous studies which suggest that those who exhibit more aggressive or masculine behavior have larger VNOs. Our results support our original finding that VNOs are not different in size in wild Microtus spp. that vary in male parental tendencies. However, the present study also indicates that M. pennsylvanicus, the species exhibiting more disparate parental tendencies, exhibited larger VNOs in females than males. This is the reverse of previous findings on rats, and we hypothesize that this difference may be due to mate selectivity and/or maternal aggression. 相似文献
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Rat antral mucosal fragments were maintained in short-term culture to examine the relative potencies and receptor specificity of the cholinergic agonist, carbachol, and adrenergic agents, norepinephrine, isoproterenol, clonidine and phenylephrine in stimulating gastrin release. Results of these studies indicate that norepinephrine and carbachol evoke pharmacologically and temporally distinctive patterns of antral gastrin release. Dose-response experiments indicate that norepinephrine is approximately 10,000 times more potent on a molar basis than carbachol in stimulating antral gastrin release. Adrenergic (norepinephrine, isoproterenol) stimulation of antral gastrin release was prevented by propranolol, and cholinergic- (carbachol) mediated peptide release was blocked by both atropine and pirenzepine. Phenylephrine and clonidine did not alter basal gastrin release. The pattern of peptide release as a function of time was quite different for each agent: norepinephrine exerted its stimulatory effect acutely during the initial 30 minutes of incubation, while carbachol exhibited a sustained stimulatory action throughout the 2-hour culture period. In conclusion, data from these studies suggests that there are marked differences between norepinephrine and carbachol in their pharmacological potency and time-dependent activation of the G cell. 相似文献
5.
Piva Jonatas Thiago Dieckow Jeferson Bayer Cimélio Zanatta Josiléia Acordi de Moraes Anibal Pauletti Volnei Tomazi Michely Pergher Maico 《Plant and Soil》2012,354(1-2):359-370
Aims
We investigated the link between tree community composition and soil microbial community biomass and structure in central-eastern Spain.Methods
The effects of the forest stand composition on the soil organic matter dynamics and on the structure and activity of the soil microbial community have been determined using phospholipid fatty acid profiles and soil enzymatic activities.Results
The soil and litter N and C contents were higher in Pinus nigra Arn. ssp. salzmannii and Quercus ilex mixed forest stands (SBHO) and in long-term unmanaged Pinus nigra Arn. ssp. salzmannii forest stands (SBPC) than in pure Pinus nigra Arn. ssp. salzmannii forest stands (SBPA) and Pinus nigra Arn. ssp. salzmannii and Juniperus thurifera mixed forest stands (SBSJ). The bacterial biomass was significantly higher in SBSJ and SBPA than in SBPC and SBHO. The results show an uncoupling of the soil microbial biomass and its activity. pH is related to microbial biomass and its community structure under a Mediterranean humid climate.Conclusions
The tree species seem to affect the biomass of the soil microbial community and its structure. The pH, but not the C/N ratio, is a factor influencing the microbial dynamics, biomass, and community structure. 相似文献
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