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排序方式: 共有176条查询结果,搜索用时 15 毫秒
1.
Ferdinand Bohlmann Cornelius Scheidges Laxmi N. Misra Jasmin Jakupovic 《Phytochemistry》1984,23(8):1795-1798
The investigation of three South African Vernonia species afforded minute amounts of five new glaucolides, two monoepoxides and three diepoxides. The structures were elucidated by 1H NMR spectroscopy. The roots of Vernonia sutherlandii contain, in addition to vernonataloide, bergamotene and santalene, minute amounts of the corresponding acetoxy derivatives. 相似文献
2.
Rajitha G. Arya C. G. Janardhan B. Laxmi S. V. Ramesh G. Kumari U. Sujana 《Russian Journal of Bioorganic Chemistry》2020,46(4):612-619
Russian Journal of Bioorganic Chemistry - Discovery towards the potent antimicrobial agents is indispensable for the treatment of infections caused by resistant microbes. Thus, we prepared a novel... 相似文献
3.
Saksena Harshita B. Sharma Manvi Singh Dhriti Laxmi Ashverya 《Journal of plant biochemistry and biotechnology.》2020,29(4):687-699
Journal of Plant Biochemistry and Biotechnology - Sugars as an energy source and a signalling molecule are indispensible for growth, development and stress responses in plants. Among sugars,... 相似文献
4.
Hari Ji Singh Nand Kishor Gour Pradeep Kumar Rao Laxmi Tiwari 《Journal of molecular modeling》2013,19(11):4815-4822
The present work deals with the theoretical investigation on the Cl initiated H-atom abstraction reaction of sevoflurane, (CF3)2CHOCH2F. A dual-level procedure has been adopted for studying the kinetics of the reaction. Geometrical optimization and frequency calculation were performed at DFT(BHandHLYP)/6-311G(d,p) while single-point energy calculation was made at CCSD(T)/6-311G(d,p) level of theory. The intrinsic reaction coordinate (IRC) calculation has also been performed to confirm the smooth transition from the reactant to product through the respective transition state. The rate constants were calculated using conventional transition state theory (TST). It has been found that 99 % of the reaction proceeded via the H-atom abstraction from the –CH2F end of the sevoflurane. The rate constant of the dominant path is found to be 1.13 × 10?13 cm3 molecule?1 s?1. This is in excellent agreement with the reported experimental rate constant of 1.10 × 10?13 cm3 molecule?1 s?1 obtained by relative rate method using FTIR/Smog chamber and LP/LIF techniques. 相似文献
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Laxmi YR Suzuki N Kim SY Shibutani S 《Bioorganic & medicinal chemistry letters》2004,14(15):4051-4054
A phosphoramidite chemical synthesis of oligodeoxynucleotides containing a diastereoisomer of (E)-alpha-(N(2)-deoxyguanosinyl)-N-desmethyltamoxifen, a major tamoxifen (TAM)-derived DNA adduct in animal and women treated with TAM, was described. The site-specifically modified oligodeoxynucleotide can be used for mutagenesis, DNA repair, and 3D structural studies and also as standard for quantitative analysis of TAM-DNA adducts in animal and human. 相似文献
8.
David C. Haws Irina Rish Simon Teyssedre Dan He Aurelie C. Lozano Prabhanjan Kambadur Zivan Karaman Laxmi Parida 《PloS one》2015,10(10)
Accurate prediction of complex traits based on whole-genome data is a computational problem of paramount importance, particularly to plant and animal breeders. However, the number of genetic markers is typically orders of magnitude larger than the number of samples (p >> n), amongst other challenges. We assessed the effectiveness of a diverse set of state-of-the-art methods on publicly accessible real data. The most surprising finding was that approaches with feature selection performed better than others on average, in contrast to the expectation in the community that variable selection is mostly ineffective, i.e. that it does not improve accuracy of prediction, in spite of p >> n. We observed superior performance despite a somewhat simplistic approach to variable selection, possibly suggesting an inherent robustness. This bodes well in general since the variable selection methods usually improve interpretability without loss of prediction power. Apart from identifying a set of benchmark data sets (including one simulated data), we also discuss the performance analysis for each data set in terms of the input characteristics. 相似文献
9.
Heggodu G. RohitKumar Kittur R. Asha Hulihalli N. KiranKumar Laxmi S. Inamdar 《Nucleosides, nucleotides & nucleic acids》2015,34(8):525-543
Circular dichroism, topological studies, molecular docking, absorbance, and fluorescence spectral titrations were employed to study the interaction of 4-morpholinopyrimido [4′,5′:4,5] selenolo (2,3-b) quinoline (MPSQ) with DNA. The association constants of MPSQ–DNA interactions were of the order of 104 M?1. Melting temperature, topological, and docking studies confirmed that the mode of interaction was by intercalation with preference to d(GpC)–d(CpG) site of DNA. Cytotoxicity studies showed the MPSQ-induced dose-dependent inhibitory effect on the proliferation of different cancer cells. Colon adenocarcinoma (COLO 205) cells are more sensitive among the cell lines tested, with an IC50 value of 15 μM. Flow cytometry revealed that MPSQ affects the cell cycle progression by arresting at G2M phase. Further, Annexin V staining, mitochondrial membrane potential assay, and caspase-3 activity assay confirmed that MPSQ leads to mitochondria-mediated apoptotic cell death in COLO 205 cells. 相似文献
10.
Laxmi Silwal-Pandit Hege Russnes Elin Borgen Veronica Skarpeteig Hans Kristian Moen Vollan Ellen Schlichting Rolf K?resen Bj?rn Naume Anne-Lise B?rresen-Dale Marianne Farnebo Anita Langer?d 《PloS one》2015,10(10)
WRAP53 protein controls intracellular trafficking of DNA repair proteins, the telomerase enzyme, and splicing factors. Functional loss of the protein has been linked to carcinogenesis, premature aging and neurodegeneration. The aim of this study was to investigate the prognostic significance of WRAP53 protein expression in breast cancer. A tissue microarray was constructed from primary breast tumors and immunostained by a polyclonal WRAP53 antibody to assess the protein expression pattern. Two different patient cohorts with long term follow-up were studied; a test- and a validation set of 154 and 668 breast tumor samples respectively. Breast cancer patients with tumor cells lacking the expression of WRAP53 in the nucleus had a significantly poorer outcome compared to patients with tumor cells expressing this protein in the nuclei (HR = 1.95, 95%CI = 1.09–3.51, p = 0.025). Nuclear localization of WRAP53 was further shown to be an independent marker of prognosis in multivariate analysis (HR = 2.57, 95%CI = 1.27–5.19, p = 0.008), and also significantly associated with better outcome in patients with TP53 mutation. Here we show that the sub-cellular localization of the WRAP53 protein has a significant impact on breast cancer survival, and thus has a potential as a clinical marker in diagnostics and treatment. 相似文献