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K. E. Popov B. N. Smetanin V. S. Gurfinkel' M. P. Kudinova V. Yu. Shlykov 《Neurophysiology》1986,18(6):548-554
A study was made on normal human subjects, using a stabilograph to investigate changes in posture produced in response to transcutaneous galvanic stimulation of the right labyrinth. Results were obtained for different head positions and under the illusion of head and trunk rotation produced by stimulating (vibrating) the gulteus maximus muscle. In the absence of illusion of movement, the direction of the vestibulomotor response was determined by the position of the head in relation to the feed: with the normal head position, the body swayed on a frontal plane, and on a sagittal plane when the heat turned through 90°. Vestibulomotor responses were sagittally oriented, as with real head turning, when illusory head and trunk turning through 90° was produced by vibration. When the illusion of head rotation (in relation to the feet) was not produced by this stimulus, the direction of the postural response was not produced by this stimulus, the direction of the postural response was determined by the real orientation of the head. It is concluded that the spatial perception system plays a major part in controlling spatially oriented vestibulomotor responses.Institute for Research into Information Transmission, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 18, No. 6, pp. 779–787, November–December, 1986. 相似文献
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M M Viadro L P Ivanitskaia L N Samo?lova M K Kudinova L E Bodunkova 《Antibiotiki i khimioterapii͡a》1989,34(5):378-382
A significant decrease in resistance to infections caused by gramnegative pathogens was observed in mice with neutropenia induced by cytostatics. Efficacy of schemes for combined chemotherapy with beta-lactams, aminoglycosides and a novel peptide antibiotic was studied on model infections in mice with neutropenia. In the neutropenic mice with sepsis caused by Pseudomonas the peptide antibiotic administered parenterally in a single dose of 50 micrograms/kg provided high therapeutic activity. In combination with azlocillin, cefotaxime and amikacin the peptide antibiotic has a synergistic therapeutic action. 相似文献
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The composition of virenomycin, a new antitumor antibiotic was studied. Two components V and M were detected with high resolution liquid chromatography and thin layer chromatography on siluphol (Czechoslovakia) and silica gel (Merk, BRD). A preparative method for separation of the antibiotic components with the use of chromatography on columns with silica gel was developed. Biological and physicochemical properties of separate components were studied to show that they significantly differed by their antibacterial action in vitro: virenomycin V was 2 to 4 times more active than virenomycin M against a number of microbes. The physicochemical properties of the components are similar. It was shown with mass spectrometry that the molecular weight of virenomycin is 12 units higher than that of virenomycin M. The PMR spectra showed that this difference is due to the presence of a vinyl group in the chromophore moiety of the virenomycin V molecule and a methyl group at the similar site of the virenomycin M molecule. 相似文献
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Kudinova A. G. Petrova M. A. Dolgikh A. V. Soina V. S. Lysak L. V. Maslova O. A. 《Microbiology》2020,89(5):574-584
Microbiology - Increasing interest in microbial communities of Arctic and Antarctic extreme environments, their taxonomic diversity, and forms and mechanisms of adaptation of inhabitants of... 相似文献
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V. K. Bozhenko N. V. Kharchenko E. F. Vaskevich E. A. Kudinova A. V. Oorzhak N. I. Rozhkova I. D. Trotsenko 《Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry》2016,10(1):75-80
Currently, no molecular biological markers do exist for early diagnosis of breast cancer. One of the possible candidates for the marker of early breast cancer is mammaglobin (MGB1) or SCGB2A2 (secretoglobin, family 2A, member 2), characterized by the maximal expression level in early breast cancer. Using the RT-PCR method MGB1 mRNA expression was examined in 57 tumor tissue samples and 57 samples of morphologically non-malignant tissue (MNT) of breast cancer (BC) patients. Specificity and sensitivity of the MGB1 mRNA assay in peripheral blood of BC patients was evaluated by nested PCR. 169 blood samples (from 95 BC patients, 22 from patients with benign breast tumors, 28 from patients with tumors of other localizations, and 24 samples from healthy donors) have been analyzed. MGB1 expression was significantly higher in BC tissue samples compared to MNT (p = 0.0019). The maximal expression level was in the samples T1 (p = 0.013), stage I BC (p = 0.037), GI (p = 0.0019). MGB1 expression positively correlated with expression of estrogen (p = 0.034) and progesterone (p = 0.0004) receptors. Sensitivity and specificity of the MGB1 mRNA assay in peripheral blood were 60.6 and 92.3%, respectively. Expression of MGB1 was higher in BC than MNT and it decreased during BC progression. The sensitivity and specificity of the MGB1 mRNA assay may be used as an additional diagnostic method. 相似文献
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Karaian AS Rabukhina NA Golubeva GI Perfil'ev SA Kudinova ES 《Vestnik rentgenologii i radiologii》2006,(4):4-7
The paper describes the evolution and consequences of different modes of eliminating orbital bottom defects and deformities that develop in posttraumatic deformities due to bone fractures of the facial mid-skeleton. Spiral computed tomography of this portion of the facial skeleton has demonstrated that the optimum results of restoration of the orbital bottom and those of elimination of eyeball displacement give the use of osteoplasty with a split parietal bone graft. 相似文献
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M V Berezkin E N Gratsinski? V F Kudinova A N Batygov L E Ponomareva O A Prikazchikova G N Zhukova 《Biulleten' eksperimental'no? biologii i meditsiny》1992,114(7):75-78
The fluctuations of activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and those of the levels of protein, glucose, cholesterol, bilirubin, creatinine, blood urea nitrogen, K+, Cl-, Na+ in blood plasma of mice in natural conditions (NC) and exposed to constant light (CL) were studied in different seasons of the year (in January, April, July, October) on days 18, 24, 6 (at 12 o'clock). Most indices both in NC and CL animals had seasonal rhythm similar for each of them. This proves a primary effect of environmental geoclimatic factors of formation of circadian periodicals as compared to desynchronization in constant light revealed by Kosinor analysis in winter (acrophase from 14.16 till 16.32 o'clock) and autumn (acrophase from 23.03 til 4.40 o'clock). During the same seasons one can observe the maximum desynchronization influences of constant light, which leads to abrupt falling (to the 10-fold and more) of the fluctuations amplitude and in some cases to stabilization of circadian rhythm. 相似文献
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A bacterial strain utilizing methanol as the sole source of carbon and energy was isolated from the maize phyllosphere. Cells
are nonpigmented gram-negative motile rods that do not form spores or prosthecae and reproduce by binary fission. The strain
does not require vitamins or supplementary growth factors. It is obligately aerobic and urease-, oxidase-, and catalase-positive.
The optimum growth temperature is 35–40°C; the optimum pH is 7.0–7.5. The doubling time is 2 h. The bacterium implements the
ribulose monophosphate pathway and possesses NAD+-dependent 6-phosphogluconate dehydrogenase and enzymes of the glutamate cycle. α-Ketoglutarate dehydrogenase and enzymes
of the glyoxylate cycle (isocitrate lyase and malate synthase) are absent. Fatty acids are dominated by palmitic (C16:0) and palmitoleic (C16:1) acids. The major phospholipids are phosphatidylethanolamine, phosphatidylglycerol, and phosphatidylcholine. Cardiolipin
is present in minor amounts. The dominant ubiquinone is Q8 The bacterial genome contains genes controlling the synthesis and secretion of cytokinins. The G+C content of DNA is 57.2
mol %, as determined from the DNA thermal denaturation temperature Tm. The bacterium shows low DNA homology (<10%) with restricted facultative methylotrophic bacteria of the genusMethylophilus (M. methylotrophus NCIMB 10515T andM. leisingerii VKM B-20131) and with the obligate methylotrophic bacterium (Methylobacillus glycogenes ATCC 29475T). DNA homology with the type representative of the genusMethylovorus, M. glucosetrophus VKM B-1745T, is high (58%). The new isolate was classified as a new species,Methylovorus mays sp. nov. 相似文献