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排序方式: 共有121条查询结果,搜索用时 15 毫秒
1.
EA Dukhanina TI Lukyanova EA Romanova V Guerriero NV Gnuchev GP Georgiev DV Yashin LP Sashchenko 《Cell cycle (Georgetown, Tex.)》2015,14(22):3635-3643
PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response. 相似文献
2.
E A Kostandov Iu L Arzumanov M F Tal'tse 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1985,35(1):52-59
Intramuscular injections of seduxen (10 mg), a benzodiasepin drug, with expressed tranquilizing and alarm suppressing effects, were used with the aim of experimental testing of a hypothesis on the neural mechanism of conditioned changes of the P300 wave. Under the action of seduxen no temporary connections could be formed between a perceived nonverbal visual stimulus and a unrecognized emotional word. The seduxen did not suppress the conditioned cortical reaction acquired due to combination of nonverbal stimulus with unrecognized emotional word. The suggestion is made that the necessary condition of temporary connection elaboration by means of a unrecognized verbal stimulus is the implication of the limbic structures where negative emotional reactions are integrated. 相似文献
3.
E A Kostandov T N Vazhnova O A Genkina N N Zakharova O I Ivashchenko 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1984,34(5):833-840
Adult healthy subjects did not manifest any difference in latency and amplitude of the wave P300 elicited by a positive ("good") and negative ("error") reinforcing stimuli. After the negative reinforcement, the P300 wave amplitude decreases in response to the standard stimulus (light bars) and increases to a lesser degree in response to test stimuli (the same bars but presented with different pauses). In the processes of learning to assess time microintervals in comparison with the standard, the latency of wave P300 to the test stimuli shortens. It is suggested that formation and consolidation of feedback connection elaborated with the participation of a reinforcing verbal stimulus constitute the physiological basis for learning of comparative assessment of time microintervals. 相似文献
4.
Kostandov EA 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》1999,85(9-10):1230-1243
Two kinds of cognitive sets for verbal and non-verbal stimuli were revealed in healthy subjects: an "intellectual blindness" and a distortion of perception and assessment of the stimuli size. Analysis of the response time to a probe stimulus and a spectral analysis of the cortical EEG revealed a participation of these sets in cortical functions: a stable set organizes and improves the stimuli perception and assessment but impedes this process in a modified situation. An optimal balance between the two sets seems to be necessary for effective cognitive activity. 相似文献
5.
Kostandov EA Kurova NS Cheremushkin EA Iakovenko IA 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2002,52(2):149-155
It was found in healthy adult subjects (n = 90) that under conditions of complication of cognitive tasks (increasing number of relevant stimuli), the stability (rigidity) of the unconscious cognitive sets markedly rises. These changes in both verbal and nonverbal sets depend on the working memory loading. The revealed dependence of the motor reaction time to the probe stimulus on the sequence of the set stimuli in a context and on the set stage suggests that unconscious cognitive sets can regulate selective attention. 相似文献
6.
Jolanda?HM?van Bilsen Josée?PA?Wagenaar-Hilbers Maarten?JF?van der Cammen Mariska?EA?van Dijk Willem?van Eden Marca?HM?WaubenEmail author 《Arthritis research & therapy》2002,4(4):R2
We have recently found that matrix metalloproteinases (MMPs) are targets for T-cell and B-cell reactivity in experimental
arthritis. In the present article, we investigate whether modulation of MMP-specific T-cell responses could influence the
course of adjuvant arthritis (AA). Lewis rats were treated nasally with MMP peptides prior to or after AA induction. Administration
of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptoms. In contrast, administration of the
MMP-10 peptide after AA induction aggravated the arthritic symptoms. The present study shows the possible usefulness of MMP
peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development
of such therapies. 相似文献
7.
Kostandov EA 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2000,86(8):928-934
The regulatory function of the set and dominanta in human cognitive activity is discussed. Role of the stimuli context in formation of the set is demonstrated. 相似文献
8.
Plasminogen activator and collagenase production by cultured capillary endothelial cells 总被引:16,自引:17,他引:16 下载免费PDF全文
Cultured bovine capillary endothelial (BCE) cells produce low levels of collagenolytic activity and significant amounts of the serine protease plasminogen activator (PA). When grown in the presence of nanomolar quantities of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), BCE cells produced 5-15 times more collagenolytic activity and 2-10 times more PA than untreated cells. The enhanced production of these enzymes was dependent on the dose of TPA used, with maximal response at 10(-7) to 10(-8) M. Phorbol didecanoate (PDD), an analog of TPA which is an active tumor promoter, also increased protease production. 4-O-methyl-TPA and 4α-PDD, two analogs of TPA which are inactive as tumor promoters, had no effect on protease production. Increased PA and collagenase activities were detected within 7.5 and 19 h, respectively, after the addition of TPA. The TPA-stimulated BCE cells synthesized a urokinase-type PA and a typical vertebrate collagenase. BCE cells were compared with bovine aortic endothelial (BAE) cells and bovine embryonic skin (BES) fibroblasts with respect to their production of protease in response to TPA. Under normal growth conditions, low levels of collagenolyic activity were detected in the culture fluids from BCE, BAE, and BES cells. BCE cells produced 5-13 times the basal levels of collagenolytic activity in response to TPA, whereas BAE cells and BES fibroblasts showed a minimal response to TPA. Both BCE and BAE cells exhibited relatively high basal levels of PA, the production of which was stimulated approximately threefold by the addition of TPA. The observation that BCE cells and not BAE cells produced high levels of both PA and collagenase activities in response to TPA demonstrates a significant difference between these two types of endothelial cells and suggests that the enhanced detectable activities are a property unique to bovine capillary and microvessel and endothelial cells. 相似文献
9.
Effects of medium viscosity on kinetic parameters of poly(U) hydrolysis catalyzed by RNase from Bac. intermedius 7P (binase) were studied in solutions of sucrose (4-50 wt. %) and glycerol (35-62 wt. %) in Tris--sodium acetate buffer (pH 7.5) at 25 degreesC. The rate constant of reaction kcat was practically unchanged over a wide range of viscosities (1-15 cP for sucrose and 2.5-3 cP for glycerol). In glycerol solutions, kcat slightly increased with viscosity increase from 4 to 10 cP. Addition of NaCl to the buffer medium resulted in an inhibitory effect of Na+ on kcat, prevented by 50% sucrose or 60% glycerol. It is concluded that binase-catalyzed poly(U) cleavage occurs through a "tense"-substrate mechanism, similarly to reactions catalyzed by alpha-chymotrypsin, trypsin, and laccase. 相似文献
10.