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Murakami Shinsuke Nakatani Jun Nakajima Kenichi Amasawa Eri Ii Ryota Hayashi Kiyotada Yoshikawa Naoki Daigo Ichiro Kishita Yusuke Ihara Tomohiko Shobatake Koichi Kudoh Yuki Motoshita Masaharu Kanemoto Keiichiro Hara Minako Kashiwagi Aiichiro Hashimoto Seiji Shigetomi Yosuke Kanzaki Masayuki Kikuchi Yasunori Ohno Hajime Fukushima Yasuhiro 《The International Journal of Life Cycle Assessment》2019,24(8):1544-1552
The International Journal of Life Cycle Assessment - 相似文献
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Nishino S Kishita A Nishida Y 《Zeitschrift für Naturforschung. C, Journal of biosciences》2001,56(11-12):1144-1149
Capillary electrophoresis and ESI-Mass spectrometry methods have revealed that a hydroperoxo-copper(II) complex with (tpa) (=tris(2-pyridylmethyl)amine) reacts with carbonic anhydrase or amyloid beta-peptide (1-40) as a nucleophile to induce the conformational change of the protein structure, while the Cu(bdpg)-complex ((bdpg)=N,N-bis(2-pyridylmethy)-beta-alanineamide) acts as an electrophile toward the proteins to degrade them under the same experimental conditions. This will lead to suggest that enhanced nucleophilic attack by a copper(II)-peroxide adduct to peptide bonding may be one of the serious origins for the "gain-of-function" by mutant superoxide dismutase and for conformational change of normal prion protein. 相似文献
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Yoshihito Kishita Aleksandra Pajak Nikhita?Ajit Bolar Carlo?M.T. Marobbio Camilla Maffezzini Daniela?V. Miniero Magnus Monné Masakazu Kohda Henrik Stranneheim Kei Murayama Karin Naess Nicole Lesko Helene Bruhn Arnaud Mourier Rolf Wibom Inger Nennesmo Ann Jespers Paul Govaert Akira Ohtake Lut Van?Laer Bart?L. Loeys Christoph Freyer Ferdinando Palmieri Anna Wredenberg Yasushi Okazaki Anna Wedell 《American journal of human genetics》2015,97(5):761-768
S-adenosylmethionine (SAM) is the predominant methyl group donor and has a large spectrum of target substrates. As such, it is essential for nearly all biological methylation reactions. SAM is synthesized by methionine adenosyltransferase from methionine and ATP in the cytoplasm and subsequently distributed throughout the different cellular compartments, including mitochondria, where methylation is mostly required for nucleic-acid modifications and respiratory-chain function. We report a syndrome in three families affected by reduced intra-mitochondrial methylation caused by recessive mutations in the gene encoding the only known mitochondrial SAM transporter, SLC25A26. Clinical findings ranged from neonatal mortality resulting from respiratory insufficiency and hydrops to childhood acute episodes of cardiopulmonary failure and slowly progressive muscle weakness. We show that SLC25A26 mutations cause various mitochondrial defects, including those affecting RNA stability, protein modification, mitochondrial translation, and the biosynthesis of CoQ10 and lipoic acid. 相似文献
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Arakaki N Nagayama A Kobayashi A Hokama Y Sadoyama Y Mogi N Kishita M Adaniya K Ueda K Higa M Shinzato T Kawamitsu H Nakama S Wakamura S Yamamura K 《Journal of economic entomology》2008,101(5):1568-1574
A mating disruption experiment to control Melanotus okinawensis Ohira (Coleoptera: Elateridae) was conducted at a sugarcane (Saccharum spp.) field and a wild Japanese pampas, Miscanthus sinensis Anderss, grassland on Minami-Daito Island (3,057 ha) from 2001 to 2007. The sugarcane field and the pampas grassland were treated with synthetic sex pheromone that evaporated from a polyethylene tube dispenser. The mean total catches obtained by monitoring traps in the sugarcane fields decreased by 96.1% in 2001 from the previous year on Minami-Daito Island. The mean total trap catches in the treated area further decreased by 74.0% from 2001 until 2007 as cumulative effects. Simultaneously, the number of adults captured by hand decreased from 4.7 per sugarcane field in 2001 to 0.5 in 2007 (89.3% reduction), whereas those captured in the untreated area (Miyagi Island) did not show such a decrease. The mating rates were significantly lower in the females captured in the treated area (14.3-71.4%) than those in the untreated area (96.9-100%). However, the amount of the decrease in the trap catches was relatively small at first (39.6% reduction) in the Japanese pampas grassland on the periphery of the Island. This was probably due to the loss of pheromone substance caused by the strong seasonal wind in the periphery. However, mean total trap catches at the periphery also decreased within several years; significant decreases were detected until 2003, 2006, and 2007. These results indicated that the mating disruption effectively reduced an isolated population of M. okinawensis. 相似文献
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Estimation of dispersal distance by mark-recapture experiments using traps: correction of bias caused by the artificial removal by traps 总被引:1,自引:1,他引:0
Kohji Yamamura Mitsunobu Kishita Norio Arakaki Futoshi Kawamura Yasutsune Sadoyama 《Population Ecology》2003,45(2):149-155
Although in mark-recapture experiments traps are useful to estimate the dispersal distance of organisms, they cause a dilemma that may be called a kind of Heisenberg effect: a large number of traps should be placed to yield a precise estimate of mean dispersal distance, while these traps shorten the mean dispersal distance itself by intercepting organisms that should have dispersed for further distances. We propose a procedure to solve this dilemma by placing traps uniformly in a lattice pattern, and by assuming a random movement and a constant rate of settlement for organisms. We applied this procedure to estimate the dispersal distance of the sugarcane wireworm Melanotus okinawensis Ohira (Coleoptera: Elateridae). The estimated mean dispersal distance was 143.8 m. Through the use of a conventional method of estimation, the mean dispersal distance was estimated to be 118.1 m. Thus, it was shown that the conventional estimate of dispersal distance was 18% smaller than the corrected estimate in our experiment. 相似文献
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Xijier Inagaki M Kishita K Yabe T Kanamaru Y 《Bioscience, biotechnology, and biochemistry》2011,75(10):2059-2062
Previous rotavirus infection studies used the focus reduction assay extensively to evaluate cellular responses to viral infection, but this technique has a number of limitations. In this study, we developed a simplified, accurate rotavirus infection assay to evaluate the effects of inhibitory substances on rotavirus infection in vitro by measurement of the fluorescence intensities of stained cells. 相似文献
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Maeda I Kishita S Yamamoto Y Arima K Ideta K Meng J Sakata N Okamoto K 《Journal of biochemistry》2007,142(5):627-631
A polyclonal antibody to elastin-derived hexapeptide repeat, H-(Val-Gly-Val-Ala-Pro-Gly)(3)-NH(2), was prepared in order to investigate the differences between elastin fibres in intimal hyperplasia and media in human atheroscleroic lesions. The hexapeptide repeat and alpha-elastin were recognized by this polyclonal antibody in enzyme-linked immunosorbent assay (ELISA), but other elastin-derived peptides such as tetrapeptide repeat, pentapeptide repeat and nonapeptide were not. In the series of hexapeptide repeats, H-(VGVAPG)(n)-NH(2) where n is 1-7, the polyclonal antibody reacted strongly with oligomers (n = 3-7) and weakly with dimer (n = 2), but not with monomer (n = 1). CD measurements suggested that the beta-turn structure is important for recognition by the polyclonal antibody. In an immunohistochemical study, elastin was stained more strongly in intimal hyperplasia than in media, suggesting that newly synthesized elastin in intimal hyperplasia is morphologically distinct from that in media. 相似文献
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Takahashi T Murakami K Nagakura M Kishita H Watanabe S Honke K Ogura K Tai T Kawasaki K Miyamoto D Hidari KI Guo CT Suzuki Y Suzuki T 《Journal of virology》2008,82(12):5940-5950
Sulfatide is abundantly expressed in various mammalian organs, including the intestines and trachea, in which influenza A viruses (IAVs) replicate. However, the function of sulfatide in IAV infection remains unknown. Sulfatide is synthesized by two transferases, ceramide galactosyltransferase (CGT) and cerebroside sulfotransferase (CST), and is degraded by arylsulfatase A (ASA). In this study, we demonstrated that sulfatide enhanced IAV replication through efficient translocation of the newly synthesized IAV nucleoprotein (NP) from the nucleus to the cytoplasm, by using genetically produced cells in which sulfatide expression was down-regulated by RNA interference against CST mRNA or overexpression of the ASA gene and in which sulfatide expression was up-regulated by overexpression of both the CST and CGT genes. Treatment of IAV-infected cells with an antisulfatide monoclonal antibody (MAb) or an anti-hemagglutinin (HA) MAb, which blocks the binding of IAV and sulfatide, resulted in a significant reduction in IAV replication and accumulation of the viral NP in the nucleus. Furthermore, antisulfatide MAb protected mice against lethal challenge with pathogenic influenza A/WSN/33 (H1N1) virus. These results indicate that association of sulfatide with HA delivered to the cell surface induces translocation of the newly synthesized IAV ribonucleoprotein complexes from the nucleus to the cytoplasm. Our findings provide new insights into IAV replication and suggest new therapeutic strategies. 相似文献
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A. Ohtake K. Murayama M. Mori H. Harashima T. Yamazaki S. Tamaru Y. Yamashita Y. Kishita Y. Nakachi M. Kohda Y. Tokuzawa Y. Mizuno Y. Moriyama H. Kato Y. Okazaki 《Biochimica et Biophysica Acta (BBA)/General Subjects》2014
Mitochondrial disorders have the highest incidence among congenital metabolic diseases, and are thought to occur at a rate of 1 in 5000 births. About 25% of the diseases diagnosed as mitochondrial disorders in the field of pediatrics have mitochondrial DNA abnormalities, while the rest occur due to defects in genes encoded in the nucleus. The most important function of the mitochondria is biosynthesis of ATP. Mitochondrial disorders are nearly synonymous with mitochondrial respiratory chain disorder, as respiratory chain complexes serve a central role in ATP biosynthesis. By next-generation sequencing of the exome, we analyzed 104 patients with mitochondrial respiratory chain disorders. The results of analysis to date were 18 patients with novel variants in genes previously reported to be disease-causing, and 27 patients with mutations in genes suggested to be associated in some way with mitochondria, and it is likely that they are new disease-causing genes in mitochondrial disorders. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research. 相似文献