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排序方式: 共有71条查询结果,搜索用时 15 毫秒
1.
P Algenstaedt N Hennigs N Telkamp B Schwarzloh C Kausch S Matthaei N Hansen-Algenstaedt H Greten 《Hormones et métabolisme》2004,36(10):686-692
Class I alpha phosphatidylinositol (PI) 3-kinase is an important enzyme in the early insulin signaling cascade, and plays a key role in insulin-mediated glucose transport. Despite extensive investigation, the genes responsible for the development of the common forms of type 2 diabetes remain unknown. This study was performed to identify variants in the coding region of p85 alpha, the regulatory subunit of PI 3-kinase. Fibroblasts from skin biopsies from type 2 diabetics and controls were established to address this issue. P85 alpha cDNA was sequenced, and a single point mutation at codon 326 was found. This mutation resulted in a homozygous missense amino acid change Met --> Ile in one subject with type 2 diabetes and heterozygous variant in two other diabetic patients and one with severe insulin resistance. Interestingly, those patients revealed an impaired insulin-mediated insulin receptor substrate (IRS)-1 binding to p85 alpha without any alteration in IRS-2/p85 alpha association. Furthermore, IRS-1, IRS-2, p85 alpha and MAPK protein contents were not significantly changed, and neither were MAPK or Akt phosphorylation. We conclude from our data that this variant may have only minor impact on signaling events; however, in combination with variants in other genes encoding signaling proteins, this may have a functional impact on early insulin signaling. 相似文献
2.
Katrin Kausch Clemens R. Müller Tiemo Grimm Kenneth Ricker Marcella Rietschel Sabine Rudnik-Schöneborn Klaus Zerres 《Human genetics》1991,86(3):317-318
Summary Two recent articles have reported the linkage of a gene for recessive spinal muscular atrophy (SMA) on the chromosome region 5q11.2–13.3. Our data show no linkage of the dominantly inherited forms of SMA to this chromosome region. 相似文献
3.
The study was made to determine if enzymatic degradation of chitin occurs in the digestive tract of the cod, Gadus morhua . The method employed corresponds to the end product measurement of Jeuniaux (1966), using 'native' chitin as the substrate. The following results were obtained.
- (1)
Chitinolytic enzyme of high activity is present in enzyme solutions from the stomach contents, gastric mucosa and intestinal contents.
- (2)
Lower chitinase activities are found in samples of the intestinal mucosa and the pyloric caeca.
- (3)
The optimum pH ranges for the action of the enzymes in the stomach and the intestine differ: 4.5–5.1 and 5.1–6.5, respectively.
- (4)
The role of chitin-decomposing bacteria is discussed, based on bacterial numbers and pH conditions in the digestive tract. The existence of two different enzyme systems is indicated.
4.
5.
Walter Kausch 《Planta》1967,73(4):328-332
Zusammenfassung An Gewächshauskulturen kann gezeigt werden, daß die Primärwurzel von Zea mays L. während der ganzen Lebensperiode der Pflanze perenniert. Da auch bei Phoenix dactylifera L. eine solche Tendenz zu erkennen ist, ist es wahrscheinlich, daß weitere Monocotylen diese Art der Bewurzelung zeigen. Es ließe sich daraus ein Maiswurzeltyp der heterogenen Radication bei den Monocotylen ableiten, bei dem primäres und sproßbürtiges Wurzelsystem dauernd nebeneinander bestehen.
The primary root of Zea mays L.
Summary Until now it has been presumed that the primary root of Zea mays L. dies very soon after the formation of the seedling. On the basis of this presumption maize root-system development has been used as an example for monocotyledons (z.B. Troll, 1937; Rauh, 1950).After passing the seedling stage, monocotyledons are said to have shoot-born roots only. There are a few hints in the literature of exceptions to this principle known in the case of some palms (Falkenberg, 1876; Fitting, 1954; Kausch, unpublished). In this paper it is shown that the primary root of maize does not die off soon, but remains living during the entire vegetation period. Investigations were made within the greenhouse, where in the stage of flowering of the plants the primary root reached downwards into the soil as far as 1.60 m (see also Fig. 2). There are also some observations in the open field showing that here too the primary root remains living until the plant dies in autumn.Nevertheless Zea mays has sekundäre Homorhizie and heterogene Radication (Troll, 1949). However, there is surely a large group within the monocotyledons which is capable of keeping the primary root system along with shoot-born roots. Of this group it may be said that it is of the Mais-Wurzel-Typ.相似文献
6.
7.
Evidence for linkage of the central core disease locus to the proximal long arm of human chromosome 19 总被引:5,自引:0,他引:5
Central core disease of muscle (CCD; MIM 117000) is a rare inheritable myopathy that is frequently found in association with susceptibility to malignant hyperthermia (MHS). This observation has prompted us to perform a linkage study in CCD families using various chromosome 19q probes that are linked to the MHS locus and map close to the ryanodine receptor gene (RYR1), a strong MHS candidate gene. Our genetic linkage data support a location of the CCD gene on proximal 19q13.1 and thus suggest that CCD and MHS may be allelic. 相似文献
8.
9.
Histochemical determinations for storage of carbohydrates in rhizomes, roots, and young shoots of Typha latifolia L. (Typhaceae) were conducted during the overwintering period from November to April. Early winter analysis showed that rhizomes and roots contained large amounts of starch (45.03% and 22.80% dry weight, respectively). The major storage tissue was parenchyma of the rhizome central core. From winter into spring a gradual decrease in storage starch in the rhizome and root occurred concurrently with starch accumulation near zones of rapid development in young shoots (buds), but the rhizome retained much starch (27.40% dry weight) into the start of its 2nd yr. 相似文献
10.
Amy M. Gancarz-Kausch Gabrielle L. Schroeder Clarisse Panganiban Danielle Adank Monica S. Humby Michael A. Kausch Stewart D. Clark David M. Dietz 《PloS one》2013,8(12)
The addicted phenotype is characterized as a long-lasting, chronically relapsing disorder that persists following long periods of abstinence, suggesting that the underlying molecular changes are stable and endure for long periods even in the absence of drug. Here, we investigated Transforming Growth Factor-Beta Type I receptor (TGF-β R1) expression in the nucleus accumbens (NAc) following periods of withdrawal from cocaine self-administration (SA) and a sensitizing regimen of non-contingent cocaine. Rats were exposed to either (i) repeated systemic injections (cocaine or saline), or (ii) self-administration (cocaine or saline) and underwent a period of forced abstinence (either 1 or 7 days of drug cessation). Withdrawal from cocaine self-administration resulted in an increase in TGF-β R1 protein expression in the NAc compared to saline controls. This increase was specific for volitional cocaine intake as no change in expression was observed following a sensitizing regimen of experimenter-administered cocaine. These findings implicate TGF-β signaling as a novel potential therapeutic target for treating drug addiction. 相似文献