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1.
T. Hanumaiah David S. Marshall B.K. Rao J.U.M. Rao K.V.J. Rao Ronald H. Thomson 《Phytochemistry》1985,24(11):2669-2672
New quinones have been isolated from the root bark of Ventilago calyculata. Ventilatones A and B are benzisochromanquinones, related to the ventiloquinones, which have an additional fused lactone ring while ventileins A and B are benzisochroman dimers having a dihydroxy-peri-xanthenoxanthenequinone chromophore. 相似文献
2.
T. Hanumaiah David S. Marshall B.K. Rao C.P. Rao G.S.R. Rao J.U.M. Rao K.V.J. Rao Ronald H. Thomson 《Phytochemistry》1985,24(10):2373-2378
From the acetone extract of the root bark of Ventilago maderaspatana eight new benzisochromanquinones; ventiloquinones A, B, C, D, E, F, G and H, have been isolated. Ventiloquinones I, J and K are three more new benzisochromanquinones isolated from the root bark of V. calyculata. The majority are 3,4,5,10-tetrahydro-cis-1,3-dimethyl-1H-naphtho[2,3-c]pyran-5,10-quinones related to eleutherin, but F, H, I, J and K are 6,9-quinones related to ventilagone. 相似文献
3.
T. Hanumaiah B.K. Rao C.P. Rao G.S.R. Rao J.U.M. Rao K.V.J. Rao David S. Marshall Ronald H. Thomson 《Phytochemistry》1985,24(8):1811-1815
Two new naphthalene derivatives and three naphthoquinones have been found in the root bark of Ventilago maderaspatana. Their structures are 2-acetyl-6,7-dimethoxy-3-methyl-1,8-methylenedioxynaphthalene (ventilaginone) and 1,3-dihydro-6,9-dihydroxy-7,8-dimethoxy-1-methylnaphtho[2,3-c]furan-3-one (ventilagol), 2(2′-acetoxypropyl)-3-hydroxy-5,7,8-trimethoxy-1,4-naphthoquinone (maderone), cordeauxione and isocordeauxione. The root bark of V. calyculata contains 2-methoxystypandrone and 1-hydroxy-6-methoxy-3-methylxanthone-8-carboxylic acid (calyxanthone). 相似文献
4.
L A Mitscher H Telikepalli P B Wang S Kuo D M Shankel G Stewart 《Mutation research》1992,267(2):229-241
Higher plants contain both mutagens and antimutagens and are susceptible to mutagenesis but screening programs for detection of antimutagenesis rarely employ higher plant systems. Short-term bacterial and mammalian tissue culture systems are the norm. Using modified screening tests for detecting antimutagenic agents, higher plants have been shown to contain a variety of structurally novel antimutagenic agents. Systematic bioassay-directed methodology resulted in the isolation in pure form and biological and chemical characterization of the responsible individual active components from various plants. The methodology in use is illustrated by the isolation of cinnamic acid, cinnamyl cinnamate and cinnamyl ricinoleate as the active constituents of the classic medicinal plant product, Styrax asiatica. The methods which may be used to reveal structure-activity relationships and to explore putative molecular modes of action are illustrated with excerpts from the same study. 相似文献
5.
Subhashchandra Naik Ozan S Kumru Melissa Cullom Srivalli N Telikepalli Elizabeth Lindboe Taylor L Roop Sangeeta B Joshi Divya Amin Phillip Gao C Russell Middaugh David B Volkin Mark T Fisher 《Protein science : a publication of the Protein Society》2014,23(10):1461-1478
The ability of a GroEL-based bio-layer interferometry (BLI) assay to detect structurally altered and/or aggregated species of pharmaceutically relevant proteins is demonstrated. Assay development included optimizing biotinylated-GroEL immobilization to streptavidin biosensors, combined with biophysical and activity measurements showing native and biotinylated GroEL are both stable and active. First, acidic fibroblast growth factor (FGF-1) was incubated under conditions known to promote (40°C) and inhibit (heparin addition) molten globule formation. Heat exposed (40°C) FGF-1 exhibited binding to GroEL-biosensors, which was significantly diminished in the presence of heparin. Second, a polyclonal human IgG solution containing 6–8% non-native dimer showed an increase in higher molecular weight aggregates upon heating by size exclusion chromatography (SEC). The poly IgG solution displayed binding to GroEL-biosensors initially with progressively increased binding upon heating. Enriched preparations of the IgG dimers or monomers showed significant binding to GroEL-biosensors. Finally, a thermally treated IgG1 monoclonal antibody (mAb) solution also demonstrated increased GroEL-biosensor binding, but with different kinetics. The bound complexes could be partially to fully dissociated after ATP addition (i.e., specific GroEL binding) depending on the protein, environmental stress, and the assay’s experimental conditions. Transmission electron microscopy (TEM) images of GroEL-mAb complexes, released from the biosensor, also confirmed interaction of bound complexes at the GroEL binding site with heat-stressed mAb. Results indicate that the GroEL-biosensor-BLI method can detect conformationally altered and/or early aggregation states of proteins, and may potentially be useful as a rapid, stability-indicating biosensor assay for monitoring the structural integrity and physical stability of therapeutic protein candidates. 相似文献
6.
Shankel DM Pillai SP Telikepalli H Menon SR Pillai CA Mitscher LA 《BioFactors (Oxford, England)》2000,12(1-4):113-121
Recently it has become increasingly clear that chemicals found in our foods and beverages can prevent the genetic damage that leads to cancer initiation. Such substances may also affect subsequent events in the pathways that lead to cancer, and may have the potential to inhibit the mutations that allow tumor cells to become resistant to antitumor agents. We describe here the antimutagenic potential of Glabrene analogs against EMS-induced mutations utilizing modified Ames tests in S. typhimurium TA 100 and E. coli JC 5088. Results of studies of the ability of well-known antioxidants such as EGCG and related compounds to prevent drug resistance mutations in microorganisms are described, and their possible significance in the prevention of chemotherapeutic drug-resistance in tumor cells is discussed. 相似文献
7.
Bowroju Suresh Kuarm Marumamula Hanumaiah Bavanthula Rajitha 《Russian Journal of Bioorganic Chemistry》2021,47(2):593-600
Russian Journal of Bioorganic Chemistry - A series of 11H-xantheno[2,1-c][1,2,5]selenadiazol-11-one derivatives (Va–m) that incorporate a variety of substituents have been synthesized under... 相似文献
8.
B.Kesava Rao T. Hanumaiah C.P. Rao G.S.R. Rao K.V.J. Rao Ronald H. Thomson 《Phytochemistry》1983,22(11):2583-2585
Eleven anthraquinones have been isolated from the root bark of Ventilago calyculata of which xanthorin-5-methyl ether and 2-hydroxyislandicin are n 相似文献
9.
A new glycoside, tamarixetin 3-rhamnoside together with kaempferol 3-rhamnoside, mearnsetin 3-rhamnoside, quercetin 3-rhamnoside, myricetin 3-rhamnoside and sitosterol glucoside, was identified from the leaves of Flemingia stricta 相似文献
10.
B.Kesava Rao T. Hanumaiah J.U.M. Rao K.V.J. Rao Ronald H. Thomson 《Phytochemistry》1984,23(9):2104-2105
Two new anthraquinones have been isolated from the root bark of ventilago calyculata and their structures shown to be 2,4,8-trihydroxy-1-methoxy-3-methylanthraquinone and 2,4,8-trihydroxy-1,6-dimethoxy-3-methyl-anthraquinone. 相似文献