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Adel M. Kamal El-Dean Geies Ahmed A. Hassanien Reda Abdel-Wadood Fatma K. El-Naeem Eman E. Abd 《Russian Journal of Bioorganic Chemistry》2022,48(4):821-834
Russian Journal of Bioorganic Chemistry - The biological uses of 2,7-naphthyridines have sparked great attention in recent years. For this reason, we synthesized a series of novel... 相似文献
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Adel M. Kamal El-Dean Remon M. Zaki Ahmed A. Geies Shaban M. Radwan Mahmoud S. Tolba 《Russian Journal of Bioorganic Chemistry》2013,39(5):553-564
Reaction of 4-chlorocoumarin-3-carbonitrile with ethyl thioglycolate and ethyl glycinate hydrochloride leads to a series of title products. Hydrazinolysis of amino thienocoumarin carboxylate afforded the hydrazino derivative which underwent various reactions to build new heterocyclic rings containing thienocoumarin moiety. Chloro acetylation of aminoester compound afforded the chloro acetyl amino which underwent nucleophilic substitution reactions with various amines. The following treatment with formaldehyde under Mannich conditions afforded the corresponding imidazo derivatives. Reaction of chloroacetylamino with potassium thiocyanate yielded ethylpyrimidothieno coumarin sulfanylacetate which was used as a versatile precursor for synthesis of other heterocycles. On the other hand, reaction of chloro coumarin carbonitrile with hydrazine gave the aminopyrazolocoumaine which reacted with bifunctionally compounds to give the substituted pyrimido derivatives. Diazotization and coupling of aminopyrazole with ethylcyanoacetate yielded ethylaminotriazinopyrazolocoumarine carboxylate. Several of the compounds obtained demonstrated considerable antifungal and antibacterial activity in the in vitro test systems. 相似文献
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Ahmed A. Geies Yasser A. Elossaily Osama Sh. Moustafa 《Russian Journal of Bioorganic Chemistry》2012,38(5):526-532
The synthesis of 3-pyrrolyl-2-substituted thieno[2,3-b]quinoxalines from the precursor 3-amino derivatives are described. Synthesized compounds were subjected to reactions with other reagents to synthe-size polyfused heterocyclic incorporated thienoquinoxaline moiety. Some of the synthesized compounds were screened for their antibacterial and antifungal activities. 相似文献
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