Electron microscopic and electron radioautographic study of cells in glandular hyperplasia and cancer of the endometrium

Peculiarities of the ultrastructure and RNA synthesis in the epithelial endometrial cells of nine patients with hyperplasia and the uterine cavity cancer have been studied by the electron-radioautographic method. Quantitative differences are revealed in the ultrastructures of the cells. Amplification of the nucleoli labelling and asynchronism of the RNA synthesis in the nucleoli with glandular hyperplasia and endometrial cancer are observed.     

Tumor-associated changes in the buccal epithelium in human breast and thyroid pathology

The estimation of the malignancy-associated changes in oral mucosa of patients with benign and malignant processes in mammary and thyroid gland is carried out on the basis of textural and densitometric indices of the interphase nuclei of the epitheliocytes with the help of the methods of mathematical statistics.     

Lipids and sterols in Musca domestica L. (Diptera, Muscidae): changes after treatment with sucrose and lead

Total lipid, fatty acid and sterol composition of larvae and adults of Musca domestica was investigated before and after feeding on sucrose syrup or on the same syrup containing 1% lead nitrate. The effects of sucrose and of lead ions were found to be different. In larvae sucrose diet inhibited the fatty acid elongation and stimulated the first stages of their unsaturation. A significant increase of phytosterol concentrations was obtained. These changes increased the cell membrane permeability. The addition of lead caused a decrease of the fatty acid unsaturation, which decreased the cell membrane permeability. In adults the sucrose diet had no effect on the lipid and sterol composition, while the addition of lead decreased the cholesterol concentration. The composition of lipids and sterols also depends on the diet of larvae before pupation. The data obtained suggested that changes in lipid and sterol composition, which control the permeability of the cell membrane, might be an adaptive response of the organism to the changes of the environment.     

Corpus uteri cancer morbidity and a genetic-mathematical analysis of the proband's pedigrees]

Steady increase of the number of women that primary fell ill with uterus cancer has noted in Ukraine in 1980-1994. The clinic-genealogical analysis of the 262 families with uterus cancer patients of the Kiev region was made. Multifactorial type of heredity predominates. Share in general tendency to malignant tumors of the genetic component was 45.64 +/- 7.20 and of the environment factors was 54.36 +/- 7.20. Closest relatives of probands with the uterus cancer have to be subjected to systematic inspection.     

Divergence in the level of DNA hybridization and formation of sibling species in the lactic acid bacteria Streptococcus thermophilus

Previously, five distinct groups with 80-90% intragroup DNA homology values were revealed among 19 lactic acid-producing bacterial strains. The study of 39 new strains of thermophilic streptococci in the present work allowed us to reveal the sixth DNA homology group. The nine strains of this group are similar, at 55-70% DNA homology levels, to the type strain S. thermophilus ATCC 19258. Group VI showed a low level of DNA-DNA reassociation (20-30%) with the DNA homology groups I, II, III, and V. The intergroup DNA-DNA reassociation values determined from DNA renaturation rates varied from 20 to 50%. These data were interpreted as indicative of the existence of at least four sibling species among the thermophilic streptococci studied.     

Cytochemical study of the RNA in rat adenohypophysis cells during mammary carcinogenesis induced by 7-12-dimethyl-(a)-benzanthracene (DMBA)

A cytochemical study of RNA was carried out in gonadotropic basophils and oxyphils of adenohypophysis of albino nonstrain rats during DMBA-induced mammary cancer growth. A stage character is found for changes in the RNA content depending on the mammary carcinogenesis phase. This shows that DMBA carcinogenic action besides a direct damage effect on the mammary gland is realized to a considerable extent through the endocrine system.