Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

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SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

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Long-lived plasmoids generated by surface microwave discharges in chemically active gases

The generation of long-lived microplasmoids is observed during the irradiation of a metal-dielectric surface with a high-power microwave beam in a chemically active gas mixture (H₂ + O₂; CH₄ + O₂). The lifetime of these plasmoids substantially exceeds the characteristic recombination and cooling times of plasmoids arising at the target surface in a chemically inactive medium.     

Eradications of invasive alien species in Europe: a review

Eradication of alien species is a key conservation tool to mitigate the impacts caused by biologic invasions. The aim of the present paper is to review the eradications successfully completed in Europe and to discuss the main limits to a wider application of this management option in the region. On the basis of the available literature – including conference proceedings, national reports to the Bern Convention, etc. – a total of 37 eradication programmes have been recorded. Thirty-three eradications were carried out on islands and four on the mainland. The rat (Rattus spp.) has been the most common target (n = 25, 67%), followed by the rabbit (n = 4). In many cases, these eradications determined a significant recovery of native biodiversity. Differently to other regions of the world, no eradications of alien invertebrates and marine organisms have been recorded; regarding invasive alien plants, it appears that only some very localized removals have been completed so far in Europe. The limited number of eradications carried out in Europe so far is probably due to the limited awareness of the public and the decision makers, the inadequacy of the legal framework, and the scarcity of resources. Synthetic guidelines for improving the ability of European states to respond to aliens incursions are presented. This revised version was published online in July 2006 with corrections to the Cover Date.     

Study of the Impact of Replacement Granularity and Associated Strategies on Video Caching

Partial caching of large media objects such as video files has been proposed recently as the caching of entire objects can easily exhaust the storage resources of a proxy server. In this paper the idea of segmenting video files into chunks and applying replacement decisions at the chunk level rather than on entire videos is examined. It is shown that a higher byte hit ratio (BHR) can be achieved by appropriately adjusting the replacement granularity. The price paid for the improved BHR performance is that the replacement algorithm takes a longer time to converge to the steady state BHR. For the segmentation of video into chunks two methods are presented. The Fixed Chunk Size segmentation scheme that is rather simple and reveals the basic trade-off between byte hit ratio (BHR) and responsiveness to changes of popularity; the Variable Chunk Size segmentation scheme that uses the request frequencies to dynamically adjust the size of the chunk and is shown to be capable of combining a small response time with high BHR. Moreover, a variation of the fixed chunk size segmentation scheme is presented, which is shown to improve its performance by switching between different chunk sizes. Video segmentation is also considered as a mechanism to provide for caching differentiation based on access costs. By employing access cost dependent chunk sizes an overall access cost reduction is demonstrated.     

<Emphasis Type="Italic">Leptocorticium</Emphasis> (Corticiaceae s.l., Basidiomycota): New species and combinations

The genus Leptocorticium is redescribed, and a key to the species is provided. A new taxon, Leptocorticium tenellum, is described, and two new combinations, L. sasae and L. utribasidiatum, are proposed. Dentocorticium nephrolepidis is determined to be conspecific with L. cyatheae. All four species are described and illustrated.