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排序方式: 共有73条查询结果,搜索用时 15 毫秒
1.
Membrane potentials, cable parameters, and component resting conductances were measured in extensor digitorum longus (EDL) muscle fibers from adult rats in vitro at 24 degrees C, after 15 to 18 days of denervation by nerve section, and at seven to ten days following epineural injection of 100 to 450 mug of colchicine in the peroneal nerve. The denervated muscles were paralyzed throughout the experimental period, whereas the colchicine-treated preparations showed no clinical paralysis except for the first day or two. The EDL from the untreated side served as a control. Both the denervated and colchicine-treated fibers were depolarized, showed signs of fibrillation, had tetrodotoxin-resistant potentials, and membrane resistance was increased two- to sevenfold. In the denervated fibers, mean chloride conductance GC1 dropped from a control value of 3196 to 596 mumhos/cm2 while mean potassium conductance GK showed a tendency to rise from 260 to 332 muhos/cm2. Colchicine-treated fibers while showing a similar fall in mean GC1 from 2993 to 1066 mumhos/cm2, also showed a significant fall in mean GK from 213 to 116 mumhos/cm2. It was concluded that factors transported by the microtubular system are important for the maintenance of the high resting GC1 of mammalian skeletal muscle fibers. 相似文献
2.
Donatella Camerino Paul Maurice Conway Samantha Sartori Paolo Campanini Madeleine Estryn‐Béhar Beatrice Isabella Johanna Maria van der Heijden 《Chronobiology international》2013,30(2-3):425-442
Satisfactory work ability is sustained and promoted by good physical and mental health and by favorable working conditions. This study examined whether favorable and rewarding work‐related factors increased the work ability among European nurses. The study sample was drawn from the Nurses' Early Exit Study and consisted of 7,516 nursing staff from seven European countries working in state‐owned and private hospitals. In all, 10.8% were day, 4.2% were permanent night, 20.9% were shift without night shift, and 64.1% were shift workers with night shifts. Participants were administered a composite questionnaire at baseline (Time 0) and 1 yr later (Time 1). The Work Ability Index (WAI) at Time 1 was used as the outcome measure, while work schedule, sleep, rewards (esteem and career), satisfaction with pay, work involvement and motivation, and satisfaction with working hours at Time 0 were included as potential determinants of work ability. Univariate and multivariate analyses were conducted after adjusting for a number of confounders (i.e., country, age, sex, type of employment, family status, and other job opportunities in the same area). Work schedule was not related to Time 1 changes in WAI. Higher sleep quality and quantity and more favorable psychosocial factors significantly increased work ability levels. Higher sleep quality and quantity did not mediate the effect of work schedule on work ability. No relevant interaction effects on work ability were observed between work schedule and the other factors considered at Time 0. As a whole, sleep and satisfaction with working time were gradually reduced from day work to permanent night work. However, scores on work involvement, motivation, and satisfaction with pay and rewards were the highest in permanent night workers and the lowest in rotating shift workers that included night shifts. 相似文献
3.
The expression pattern of a mouse doublesex-related gene is consistent with a role in gonadal differentiation 总被引:16,自引:0,他引:16
De Grandi A Calvari V Bertini V Bulfone A Peverali G Camerino G Borsani G Guioli S 《Mechanisms of development》2000,90(2):323-326
The signal for somatic sex determination in mammals, Caenorhabditis elegans and Drosophila melanogaster is chromosomal, but the overall mechanisms do not appear to be conserved between the phyla. However it has been found quite recently that the C. elegans sex-determining gene Mab-3 contains a domain highly homologous to the Drosophila sex-determining gene doublesex (dsx) and shares a similar role. These data suggest that at least some aspects of the regulation of sex determination might be conserved. In humans, a doublesex-related gene (DMRT1) was identified at less than 30 kb from the critical region for sex reversal on chromosome 9p24 (TD9). In order to get insights into the role of DMRT1 in sex determination/differentiation, we have isolated DMRT1 mouse homologue (Dmrt1) and analysed its expression pattern. The gene is expressed in the genital ridges of both sexes during the sex-determining switch and it shows male/female dimorphism at late stages of sex differentiation. 相似文献
4.
Stereospecific synthesis of "para-hydroxymexiletine" and sodium channel blocking activity evaluation
Catalano A Carocci A Fracchiolla G Franchini C Lentini G Tortorella V De Luca A De Bellis M Desaphy JF Conte Camerino D 《Chirality》2004,16(2):72-78
Both enantiomers of "para-hydroxymexiletine" (PHM), one of the main metabolites of mexiletine, were synthesized and fully characterized. Properties of (R)- and (S)-PHM, in terms of blocking potency and stereoselectivity on frog skeletal muscle Na(+) channels, were evaluated. The presence of a hydroxy group on the aryloxy moiety in the 4-position, as in PHM, reduced potency with respect to mexiletine in reducing I(Na max). However, PHM showed clear use-dependent behavior similar to that of mexiletine and, in contrast with what is observed with the parent compound, maintained its stereoselectivity during the use-dependent block. Chirality 16:72-78, 2004. 相似文献
5.
The higher metabolic rate of dominant individuals, found in different species, has been interpreted as the cost that prevents subordinates from cheating by adopting large badges of status. However, an alternative prediction for status-signalling species, in which subordinates may recognize dominants, is that subordinates have the higher metabolic rate because of the greater stress of locating and actively avoiding aggressive interactions with them. In this study, the size of the black bib of the siskin, Carduelis spinus, which is a badge of dominance, was negatively correlated with metabolic rate in daylight, even when controlling for the bird's activity level in the respirometer chamber and its body mass. The size of the black bib, however, was not correlated with metabolic rate in darkness. This suggests that the difference between dominance classes is not related to intrinsic physiological differences, but that subordinates are more susceptible to stressful conditions. When controlling for metabolic rate, a positive correlation appeared between dominance status and body mass. This stresses the importance of knowing the effects of social status on energy requirements for understanding the relationship between body mass and dominance. We conclude that maintaining a high social status may be more stressful to subordinates than to dominant birds. Copyright 2000 The Association for the Study of Animal Behaviour. 相似文献
6.
7.
Patano N Marinaccio M Vimercati A Camerino C Mancini L Selvaggi L Zallone A 《Biochemical and biophysical research communications》2005,334(2):487-490
In the pre-expulsive and expulsive phases of labor, oxytocin and several other osteoclastogenic mediators, such as prostaglandins and IL-6, are secreted in high concentrations. This study was undertaken to assess whether the peripheral blood obtained from healthy women after vaginal delivery contains a larger pool of osteoclast precursors compared with age- and gender-matched controls. Our results clearly show that the number and size of osteoclasts generated in vitro from osteoclast precursors isolated from women after delivery are significantly larger than those from controls. This finding can account for the decrease in bone mass that is often observed during the breastfeeding period and the concomitant release of high quantities of calcium in the milk. Further investigations are required to establish whether analysis of blood osteoclast precursors can be predictive of changes in bone remodeling in this setting. 相似文献
8.
9.
B. Dabovic E. Zanaria B. Bardoni A. Lisa C. Bordignon V. Russo C. Matessi C. Traversari G. Camerino 《Mammalian genome》1995,6(9):571-580
Patients with an intact SRY gene and duplications of portions of Xp21 develop as phenotypic females. We have recently mapped this sex reversal locus, DSS, to a 160-kb region of Xp21 that includes the adrenal hypoplasia congenita locus. To clone the gene(s) underlying DSS and AHC, we isolated expressed sequences quences from the region. Here we describe the characterization of two related genes. DAM10 and DAM6, expressed in adult testis and lung tumors. The predicted DAM10 and DAM6 proteins are 66% identical and are both highly similar to the MAGE family of tumor-associated antigens and to mouse necdin. Genes belonging to the MAGE superfamily, DAMs, MAGEs, and necdin, are likely to have originated from a common ancestor and to be subject to an unusually rapid evolution. The tumor-restricted expression of DAM proteins and their structural similarity to MAGE genes suggest that DAM peptides may be targets for active immunotherapy in lung cancer patients. 相似文献
10.