共查询到20条相似文献，搜索用时 31 毫秒
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《Nucleosides, nucleotides & nucleic acids》2013,32(4-7):1025-1028
The presence of the lamivudine-associated M184V RT mutation increases tenofovir susceptibility in multiple HIV genotypes. Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. HIV with common forms of zidovudine and lamivudine resistance are susceptible to tenofovir, corroborating phase II clinical results demonstrating the activity of tenofovir DF in treatment-experienced patients. 相似文献
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Miller MD Margot NA Hertogs K Larder B Miller V 《Nucleosides, nucleotides & nucleic acids》2001,20(4-7):1025-1028
The presence of the lamivudine-associated M184V RT mutation increases tenofovir susceptibility in multiple HIV genotypes. Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. HIV with common forms of zidovudine and lamivudine resistance are susceptible to tenofovir, corroborating phase II clinical results demonstrating the activity of tenofovir DF in treatment-experienced patients. 相似文献
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Deval J Alvarez K Selmi B Bermond M Boretto J Guerreiro C Mulard L Canard B 《The Journal of biological chemistry》2005,280(5):3838-3846
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Comparative selection of the K65R and M184V/I mutations in human immunodeficiency virus type 1-infected patients enrolled in a trial of first-line triple-nucleoside analog therapy (Tonus IMEA 021) 总被引：1，自引：0，他引：1 
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下载免费PDF全文 Delaunay C Brun-Vézinet F Landman R Collin G Peytavin G Trylesinski A Flandre P Miller M Descamps D 《Journal of virology》2005,79(15):9572-9578
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Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors 总被引：4，自引：0，他引：4 下载免费PDF全文
下载免费PDF全文 Svicher V Sing T Santoro MM Forbici F Rodríguez-Barrios F Bertoli A Beerenwinkel N Bellocchi MC Gago F d'Arminio Monforte A Antinori A Lengauer T Ceccherini-Silberstein F Perno CF 《Journal of virology》2006,80(14):7186-7198
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Violin M Forbici F Cozzi-Lepri A Velleca R Bertoli A Riva C Giannella S Manconi PE Lazzarin A Pasquinucci S Tacconi L Carnevale G Mazzotta F Bonazzi L Montroni M Chirianni A Capobianchi M Ippolito G Moroni M Perno CF D'Arminio-Monforte A;I.CO.N.A. Study Group. Italian Cohort of Antiretroviral Naive patients 《Journal of biological regulators and homeostatic agents》2002,16(1):37-43
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Knoepfel SA Salisch NC Huelsmann PM Rauch P Walter H Metzner KJ 《Journal of virology》2008,82(13):6536-6545
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Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues 下载免费PDF全文
下载免费PDF全文 Bouchonnet F Dam E Mammano F de Soultrait V Henneré G Benech H Clavel F Hance AJ 《Journal of virology》2005,79(2):812-822
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