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The molecular events whereby gastrin occupancy of G/CCK(B) receptors leads to phosphatidylinositol (PI) 3-kinase activation have been examined. We report here that this peptide promotes the association between two non-receptor tyrosine kinases, p60Src and p125FAK, and elicits a parallel increase in tyrosine phosphorylation and activity of both kinases. Gastrin-induced PI 3-kinase activity was coprecipitated with p60Src and p125FAK and was inhibited by herbimycin A, the selective Src inhibitor PP-2 or cytochalasin D, which disrupts the actin cytoskeleton and prevents p125FAK activity. These results indicate, for the first time, that a p60Src/p125FAK complex acts upstream of the gastrin-stimulated PI 3-kinase pathway. 相似文献
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Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression 总被引:3,自引:0,他引:3 下载免费PDF全文
Marshak S Benshushan E Shoshkes M Havin L Cerasi E Melloul D 《Molecular and cellular biology》2000,20(20):7583-7590
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Tarumi T Kravtsov DV Zhao M Williams SM Gailani D 《The Journal of biological chemistry》2002,277(21):18510-18516
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Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. 总被引:22,自引:0,他引:22
E Barbacci M Reber M O Ott C Breillat F Huetz S Cereghini 《Development (Cambridge, England)》1999,126(21):4795-4805
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