共查询到20条相似文献,搜索用时 140 毫秒
1.
2.
3.
4.
5.
《Progress in growth factor research》1990,2(3):181-192
The overall control of the haemopoietic system is ultimately articulated at the level of stem cell proliferative regulation. An understanding of the control processes involved is central to a full understanding of the regulation of haemopoiesis in health and disease. We describe here the recent advances in understanding of the negative regulation of primitive haemopoietic cells. The possible involvement of inhibitory factors in the development of haemopoietic malignancy is discussed. The known biological functions of many of these inhibitory molecules suggests a therapeutic potential for negative regulators. 相似文献
6.
7.
8.
9.
10.
Petros Papadopoulos Laura Gutiérrez Jeroen Demmers Elisabeth Scheer Farzin Pourfarzad Dimitris N. Papageorgiou Elena Karkoulia John Strouboulis Harmen J. G. van de Werken Reinier van der Linden Peter Vandenberghe Dick H. W. Dekkers Sjaak Philipsen Frank Grosveld Làszlò Tora 《Molecular and cellular biology》2015,35(12):2103-2118
11.
12.
13.
Id genes in nervous system development 总被引:3,自引:0,他引:3
14.
15.
16.
Hamood AlSudais Kawther Aabed William Nicola Katherine Dixon Jihong Chen Qiao Li 《The Journal of biological chemistry》2016,291(6):3090-3099
The differentiation and fusion of myoblasts into mature myotubes are complex processes responding to multiple signaling pathways. The function of Akt/PKB is critical for myogenesis, but less is clear as to the regulation of its isoform-specific expression. Bexarotene is a drug already used clinically to treat cancer, and it has the ability to enhance the commitment of embryonic stem cells into skeletal muscle lineage. Whereas bexarotene regulates fundamental biological processes through retinoid X receptor (RXR)-mediated gene expression, molecular pathways underlying its positive effects on myogenesis remain unclear. In this study, we have examined the signaling pathways that transmit bexarotene action in the context of myoblast differentiation. We show that bexarotene promotes myoblast differentiation and fusion through the activation of RXR and the regulation of Akt/PKB isoform-specific expression. Interestingly, bexarotene signaling appears to correlate with residue-specific histone acetylation and is able to counteract the detrimental effects of cachectic factors on myogenic differentiation. We also signify an isoform-specific role for Akt/PKB in RXR-selective signaling to promote and to retain myoblast differentiation. Taken together, our findings establish the viability of applying bexarotene in the prevention and treatment of muscle-wasting disorders, particularly given the lack of drugs that promote myogenic differentiation available for potential clinical applications. Furthermore, the model of bexarotene-enhanced myogenic differentiation will provide an important avenue to identify additional genetic targets and specific molecular interactions that we can study and apply for the development of potential therapeutics in muscle regeneration and repair. 相似文献
17.
MicroRNAs Involved in Skeletal Muscle Differentiation 总被引:1,自引:0,他引:1
MicroRNAs (miRNAs) negatively regulate gene expression by promoting degradation of target mRNAs or inhibiting their translation. Previous studies have expanded our understanding that miRNAs play an important role in myogenesis and have a big impact on muscle mass, muscle fiber type and muscle-related diseases. The muscle-specific miRNAs, miR-206, miR-1 and miR-133, are among the most studied and best characterized miRNAs in skeletal muscle differentiation. They have a profound influence on multiple muscle differ-entiation processes, such as alternative splicing, DNA synthesis, and cell apoptosis. Many non-muscle-specific miRNAs are also required for the differentiation of muscle through interaction with myogenic factors. Studying the regulatory mechanisms of these miRNAs in muscle differentiation will extend our knowledge of miRNAs in muscle biology and will improve our understanding of the myogenesis regulation. 相似文献
18.
19.
20.
Regulation of gene expression in vertebrate skeletal muscle 总被引:2,自引:0,他引:2