Small,but powerful and attractive: 19F in biomolecular NMR

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Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development

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In situ identification of cellular drug targets in mammalian tissue

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Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design

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Structural basis of γ-secretase inhibition and modulation by small molecule drugs

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Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

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How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view

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Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

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Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy

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Evolving cryo-EM structural approaches for GPCR drug discovery

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High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

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Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes

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Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor

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Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis

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Hidden behavioral fingerprints in epilepsy

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BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

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Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels

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Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps

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